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- W3201700603 startingPage "1595" @default.
- W3201700603 abstract ": Schistosomiasis ranks among the most important infectious diseases, with over 200 million people currently being infected and > 280,000 deaths reported annually. Chemotherapeutic treatment has relied on one drug, praziquantel, for four decades, while other drugs, such as oxamniquine and metrifonate, are no longer preferred for clinical use due to their narrow spectrum of activity - these are only active against S. mansoni and S. haematobium, respectively. Despite being cheap, safe, and effective against all schistosome species, praziquantel is ineffective against immature worms, which may lead to reinfections and treatment failure in endemic areas; a situation that necessitates repeated administration besides other limitations. Therefore, novel drugs are urgently needed to overcome this situation. In this paper, an up to date review of drug targets identified and validated against schistosomiasis while also encompassing promising clinical and preclinical candidate drugs is presented. While there are considerable efforts aimed at identifying and validating drug targets, the pipeline for new antischistosomals is dry. Moreover, the majority of compounds evaluated preclinically are not really advanced because most of them were evaluated in very small preclinical species such as mice alone. Overall, it appears that although a lot of research is going on at discovery phases, unfortunately, it does not translate to advanced preclinical and clinical evaluation." @default.
- W3201700603 created "2021-10-11" @default.
- W3201700603 creator A5069649619 @default.
- W3201700603 date "2022-07-01" @default.
- W3201700603 modified "2023-10-18" @default.
- W3201700603 title "Drug Discovery and Target Identification against Schistosomiasis: A Reality Check on Progress and Future Prospects" @default.
- W3201700603 cites W1511198581 @default.
- W3201700603 cites W1532707293 @default.
- W3201700603 cites W160231570 @default.
- W3201700603 cites W1654828326 @default.
- W3201700603 cites W1782287000 @default.
- W3201700603 cites W1860242155 @default.
- W3201700603 cites W1963728755 @default.
- W3201700603 cites W1963923482 @default.
- W3201700603 cites W1964248507 @default.
- W3201700603 cites W1964897436 @default.
- W3201700603 cites W1964943230 @default.
- W3201700603 cites W1968226741 @default.
- W3201700603 cites W1968438075 @default.
- W3201700603 cites W1968796392 @default.
- W3201700603 cites W1969589255 @default.
- W3201700603 cites W1972029787 @default.
- W3201700603 cites W1976147671 @default.
- W3201700603 cites W1978378727 @default.
- W3201700603 cites W1979187818 @default.
- W3201700603 cites W1981867699 @default.
- W3201700603 cites W1982187630 @default.
- W3201700603 cites W1982814288 @default.
- W3201700603 cites W1983815517 @default.
- W3201700603 cites W1987338737 @default.
- W3201700603 cites W1990715120 @default.
- W3201700603 cites W1991658714 @default.
- W3201700603 cites W1992978957 @default.
- W3201700603 cites W1993176720 @default.
- W3201700603 cites W1993867737 @default.
- W3201700603 cites W1995194243 @default.
- W3201700603 cites W1996131891 @default.
- W3201700603 cites W1997628033 @default.
- W3201700603 cites W2003152268 @default.
- W3201700603 cites W2004762054 @default.
- W3201700603 cites W2005766161 @default.
- W3201700603 cites W2005888303 @default.
- W3201700603 cites W2006401070 @default.
- W3201700603 cites W2013824927 @default.
- W3201700603 cites W2022952570 @default.
- W3201700603 cites W2025540821 @default.
- W3201700603 cites W2027133190 @default.
- W3201700603 cites W2037139254 @default.
- W3201700603 cites W2037874673 @default.
- W3201700603 cites W2038178479 @default.
- W3201700603 cites W2040807402 @default.
- W3201700603 cites W2042007637 @default.
- W3201700603 cites W2046323432 @default.
- W3201700603 cites W2047199712 @default.
- W3201700603 cites W2049374415 @default.
- W3201700603 cites W2049493521 @default.
- W3201700603 cites W2050591472 @default.
- W3201700603 cites W2050960215 @default.
- W3201700603 cites W2051787881 @default.
- W3201700603 cites W2051905139 @default.
- W3201700603 cites W2054621094 @default.
- W3201700603 cites W2056205420 @default.
- W3201700603 cites W2056474673 @default.
- W3201700603 cites W2057264061 @default.
- W3201700603 cites W2058074298 @default.
- W3201700603 cites W2058348572 @default.
- W3201700603 cites W2059515537 @default.
- W3201700603 cites W2061360494 @default.
- W3201700603 cites W2061431926 @default.
- W3201700603 cites W2062123506 @default.
- W3201700603 cites W2064138320 @default.
- W3201700603 cites W2066923327 @default.
- W3201700603 cites W2068408381 @default.
- W3201700603 cites W2068696470 @default.
- W3201700603 cites W2071429505 @default.
- W3201700603 cites W2074537157 @default.
- W3201700603 cites W2076706878 @default.
- W3201700603 cites W2077010275 @default.
- W3201700603 cites W2077588719 @default.
- W3201700603 cites W2080504080 @default.
- W3201700603 cites W2081828696 @default.
- W3201700603 cites W2082620725 @default.
- W3201700603 cites W2084658291 @default.
- W3201700603 cites W2087194936 @default.
- W3201700603 cites W2087481516 @default.
- W3201700603 cites W2088245562 @default.
- W3201700603 cites W2089465395 @default.
- W3201700603 cites W2090333443 @default.
- W3201700603 cites W2091823485 @default.
- W3201700603 cites W2092604097 @default.
- W3201700603 cites W2092637691 @default.
- W3201700603 cites W2093915276 @default.
- W3201700603 cites W2094255857 @default.
- W3201700603 cites W2098082628 @default.
- W3201700603 cites W2101005114 @default.
- W3201700603 cites W2104479866 @default.
- W3201700603 cites W2105496367 @default.
- W3201700603 cites W2106307542 @default.