Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201710122> ?p ?o ?g. }
- W3201710122 endingPage "1946" @default.
- W3201710122 startingPage "1946" @default.
- W3201710122 abstract "Immature HIV virions harbor a lattice of Gag molecules with significant ordering in CA-NTD, CA-CTD and SP1 regions. This ordering plays a major role during HIV maturation. To test the condition in which the Gag lattice forms in vivo, we assembled virus like particles (VLPs) by expressing only HIV Gag in mammalian cells. Here we show that these VLPs incorporate a similar number of Gag molecules compared to immature HIV virions. However, within these VLPs, Gag molecules diffuse with a pseudo-diffusion rate of 10 nm2/s, this pseudo-diffusion is abrogated in the presence of melittin and is sensitive to mutations within the SP1 region. Using cryotomography, we show that unlike immature HIV virions, in the Gag lattice of VLPs the CA-CTD and SP1 regions are significantly less ordered. Our observations suggest that within immature HIV virions, other viral factors in addition to Gag, contribute to ordering in the CA-CTD and SP1 regions." @default.
- W3201710122 created "2021-10-11" @default.
- W3201710122 creator A5016276151 @default.
- W3201710122 creator A5019909886 @default.
- W3201710122 creator A5029874980 @default.
- W3201710122 creator A5040706412 @default.
- W3201710122 creator A5041527227 @default.
- W3201710122 creator A5070425566 @default.
- W3201710122 creator A5076250985 @default.
- W3201710122 creator A5076335445 @default.
- W3201710122 creator A5079956171 @default.
- W3201710122 date "2021-09-28" @default.
- W3201710122 modified "2023-10-18" @default.
- W3201710122 title "Gag-Gag Interactions Are Insufficient to Fully Stabilize and Order the Immature HIV Gag Lattice" @default.
- W3201710122 cites W126493026 @default.
- W3201710122 cites W1664638011 @default.
- W3201710122 cites W1924577704 @default.
- W3201710122 cites W1967562476 @default.
- W3201710122 cites W1975227291 @default.
- W3201710122 cites W1977218442 @default.
- W3201710122 cites W1986015062 @default.
- W3201710122 cites W1991815226 @default.
- W3201710122 cites W1999148331 @default.
- W3201710122 cites W2008457983 @default.
- W3201710122 cites W2015002417 @default.
- W3201710122 cites W2030994365 @default.
- W3201710122 cites W2042649563 @default.
- W3201710122 cites W2061714407 @default.
- W3201710122 cites W2062334646 @default.
- W3201710122 cites W2074560169 @default.
- W3201710122 cites W2076965602 @default.
- W3201710122 cites W2087978946 @default.
- W3201710122 cites W2112727291 @default.
- W3201710122 cites W2115382947 @default.
- W3201710122 cites W2133650360 @default.
- W3201710122 cites W2135648640 @default.
- W3201710122 cites W2141194382 @default.
- W3201710122 cites W2141556708 @default.
- W3201710122 cites W2142161929 @default.
- W3201710122 cites W2152539875 @default.
- W3201710122 cites W2163060880 @default.
- W3201710122 cites W2167680425 @default.
- W3201710122 cites W2169310292 @default.
- W3201710122 cites W2414000364 @default.
- W3201710122 cites W2466725324 @default.
- W3201710122 cites W2470140135 @default.
- W3201710122 cites W2472495991 @default.
- W3201710122 cites W2609187905 @default.
- W3201710122 cites W2766789190 @default.
- W3201710122 cites W2782939777 @default.
- W3201710122 cites W2883450411 @default.
- W3201710122 cites W2886259097 @default.
- W3201710122 cites W2891492340 @default.
- W3201710122 cites W2991106891 @default.
- W3201710122 cites W2994798248 @default.
- W3201710122 cites W3024961866 @default.
- W3201710122 cites W3037530152 @default.
- W3201710122 cites W3049198861 @default.
- W3201710122 cites W3081460628 @default.
- W3201710122 cites W3092270865 @default.
- W3201710122 cites W3120649156 @default.
- W3201710122 cites W3134041051 @default.
- W3201710122 doi "https://doi.org/10.3390/v13101946" @default.
- W3201710122 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8540168" @default.
- W3201710122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34696376" @default.
- W3201710122 hasPublicationYear "2021" @default.
- W3201710122 type Work @default.
- W3201710122 sameAs 3201710122 @default.
- W3201710122 citedByCount "4" @default.
- W3201710122 countsByYear W32017101222022 @default.
- W3201710122 countsByYear W32017101222023 @default.
- W3201710122 crossrefType "journal-article" @default.
- W3201710122 hasAuthorship W3201710122A5016276151 @default.
- W3201710122 hasAuthorship W3201710122A5019909886 @default.
- W3201710122 hasAuthorship W3201710122A5029874980 @default.
- W3201710122 hasAuthorship W3201710122A5040706412 @default.
- W3201710122 hasAuthorship W3201710122A5041527227 @default.
- W3201710122 hasAuthorship W3201710122A5070425566 @default.
- W3201710122 hasAuthorship W3201710122A5076250985 @default.
- W3201710122 hasAuthorship W3201710122A5076335445 @default.
- W3201710122 hasAuthorship W3201710122A5079956171 @default.
- W3201710122 hasBestOaLocation W32017101221 @default.
- W3201710122 hasConcept C12554922 @default.
- W3201710122 hasConcept C153911025 @default.
- W3201710122 hasConcept C159047783 @default.
- W3201710122 hasConcept C185592680 @default.
- W3201710122 hasConcept C2522874641 @default.
- W3201710122 hasConcept C3013748606 @default.
- W3201710122 hasConcept C86803240 @default.
- W3201710122 hasConcept C95444343 @default.
- W3201710122 hasConceptScore W3201710122C12554922 @default.
- W3201710122 hasConceptScore W3201710122C153911025 @default.
- W3201710122 hasConceptScore W3201710122C159047783 @default.
- W3201710122 hasConceptScore W3201710122C185592680 @default.
- W3201710122 hasConceptScore W3201710122C2522874641 @default.
- W3201710122 hasConceptScore W3201710122C3013748606 @default.
- W3201710122 hasConceptScore W3201710122C86803240 @default.
- W3201710122 hasConceptScore W3201710122C95444343 @default.