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• W3201713041 abstract "Abstract Amylase genes reside in a structurally complex locus, and their copy numbers vary greatly, especially among agricultural races. Amylase genes seem to shape the metabolic response to dietary starch, and several studies have reported their association with obesity. Besides, the effect of amylase copy numbers seems to depend on lifestyle, and the mechanism of this effect was partially explained by changes in the oral and gut microbiome compositions; however, a detailed mechanism has been unclarified. In this study, we showed their association with diabetes in addition to obesity, and further discovered a plausible mechanism of this association based on the function of commensal bacterial in a northern Japanese population. First, we confirmed that the amylase copy number in the population tends to be larger than that reported in other studies and that there is a positive association between obesity and diabetes (p =1.95E-2 and 3.28E-2). Second, we identified that relative abundance of some genus level microbiome, Capnocytophaga, Dialister , and previously reported bacteria, were significantly associated with amylase copy numbers. Finally, through functional gene-set analysis using shotgun sequencing, we observed that the abundance of genes in the Acarbose pathway in the gut microbiome was significantly decreased with an increase in the amylase copy number (p-value = 5.80E-4), which can partly explain the mechanism underlying obesity and diabetes in populations with high amylase copy numbers." @default.
• W3201713041 created "2021-10-11" @default.
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• W3201713041 date "2021-10-04" @default.
• W3201713041 modified "2023-10-01" @default.
• W3201713041 title "Impact of Salivary and Pancreatic Amylase Gene Copy Numbers on Diabetes, Obesity, and Functional Profiles of Microbiome in Northern Japanese Population" @default.
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• W3201713041 doi "https://doi.org/10.1101/2021.10.02.21264452" @default.
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