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• W3201717976 abstract "Despite advances in our understanding of cancer biology, the development of standardized, effective local control measures with surgery and radiation, and the emergence of targeted therapies, bone sarcoma survival rates remain unchanged for more than 30 years. Bone sarcomas still represent therapeutic challenges, and the low success of targeted therapies in these tumors highlights the fact that we have to take their environment particularly the immune part of it into account. In the past 40 years, there has been remarkable progress in both the understanding of the immune system and of the ways to turn it on and off to treat cancer. Immunotherapy strategies for sarcomas are comparatively less advanced. Evidence from mouse models supports a major role for the immune system in preventing the development and progression of these cancers. In terms of immunology, bone sarcomas were long considered as cold tumors or event as immune desert for the cartilaginous tumors like chondrosarcoma and chordoma. Over the recent years, studies have been conducted to describe these tumors' immune environment. The goal is to better understand the interrelations between tumor and the immune components in order to design therapies adapted to bone sarcoma immune specificities. The purpose of this chapter is to describe the knowledge of the immune environment of three major bone tumors (osteosarcoma, chondrosarcoma, and chordoma) and the immunotherapies that are in development and could offer therapeutic options for these tumors." @default.
• W3201717976 created "2021-10-11" @default.
• W3201717976 creator A5049435579 @default.
• W3201717976 creator A5075383339 @default.
• W3201717976 date "2022-01-01" @default.
• W3201717976 modified "2023-10-09" @default.
• W3201717976 title "The immune environment of bone sarcomas" @default.
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• W3201717976 doi "https://doi.org/10.1016/b978-0-12-821666-8.00070-0" @default.
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