Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201723912> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W3201723912 abstract "Abstract Background: Uveal melanoma (UM) is an aggressive primary intraocular tumor in adults, with high metastatic capacity and high morbidity. However, the mechanisms of UM metastasis have not been clearly elucidated. Methods: The PTK2 expression and activation were performed in the Cancer Genome Atlas (TCGA) database and 25 patients of UM. The role of PTK2 in promoting metastasis was explored in vitro and in vivo. Subsequently, we revealed the correlation between PTK2 expression and epithelial-to-mesenchymal transition (EMT). Finally, we explored the reason for the high expression of PTK2 in UM. Results: Our study found that protein tyrosine kinase 2 (PTK2) was overexpressed in UM specimens, and as a novel independent risk factor, its overexpression predicted the poor survival of UM patients. For the molecular mechanism, PTK2 promoted EMT phenotype, thus leading to tumor metastasis in UM cells. Subsequently, we have demonstrated that PTK2 was a functional gene of chromosome 8q gain accounting for UM metastasis, providing a novel molecular mechanism for the aberrantly expression and activation of PTK2 in UM. Conclusion: Our data reveal the important role and mechanism of PTK2 in the metastatic process of UM, which may clue to a new predictive biomarker for UM metastasis and a new therapeutic target for UM treatment." @default.
- W3201723912 created "2021-10-11" @default.
- W3201723912 creator A5012641833 @default.
- W3201723912 creator A5026123578 @default.
- W3201723912 creator A5028963628 @default.
- W3201723912 creator A5032983895 @default.
- W3201723912 creator A5048961496 @default.
- W3201723912 creator A5053818928 @default.
- W3201723912 creator A5057754105 @default.
- W3201723912 creator A5067865085 @default.
- W3201723912 creator A5071798264 @default.
- W3201723912 creator A5079467600 @default.
- W3201723912 creator A5086747333 @default.
- W3201723912 date "2021-09-30" @default.
- W3201723912 modified "2023-10-16" @default.
- W3201723912 title "PTK2 Promotes Uveal Melanoma Metastasis by Activating Epithelial-to-Mesenchymal Transition" @default.
- W3201723912 doi "https://doi.org/10.21203/rs.3.rs-885745/v1" @default.
- W3201723912 hasPublicationYear "2021" @default.
- W3201723912 type Work @default.
- W3201723912 sameAs 3201723912 @default.
- W3201723912 citedByCount "0" @default.
- W3201723912 crossrefType "posted-content" @default.
- W3201723912 hasAuthorship W3201723912A5012641833 @default.
- W3201723912 hasAuthorship W3201723912A5026123578 @default.
- W3201723912 hasAuthorship W3201723912A5028963628 @default.
- W3201723912 hasAuthorship W3201723912A5032983895 @default.
- W3201723912 hasAuthorship W3201723912A5048961496 @default.
- W3201723912 hasAuthorship W3201723912A5053818928 @default.
- W3201723912 hasAuthorship W3201723912A5057754105 @default.
- W3201723912 hasAuthorship W3201723912A5067865085 @default.
- W3201723912 hasAuthorship W3201723912A5071798264 @default.
- W3201723912 hasAuthorship W3201723912A5079467600 @default.
- W3201723912 hasAuthorship W3201723912A5086747333 @default.
- W3201723912 hasBestOaLocation W32017239121 @default.
- W3201723912 hasConcept C108391706 @default.
- W3201723912 hasConcept C121608353 @default.
- W3201723912 hasConcept C126322002 @default.
- W3201723912 hasConcept C184235292 @default.
- W3201723912 hasConcept C2777658100 @default.
- W3201723912 hasConcept C2779013556 @default.
- W3201723912 hasConcept C502942594 @default.
- W3201723912 hasConcept C71924100 @default.
- W3201723912 hasConcept C76419328 @default.
- W3201723912 hasConcept C86803240 @default.
- W3201723912 hasConcept C90934575 @default.
- W3201723912 hasConcept C95444343 @default.
- W3201723912 hasConcept C97029542 @default.
- W3201723912 hasConceptScore W3201723912C108391706 @default.
- W3201723912 hasConceptScore W3201723912C121608353 @default.
- W3201723912 hasConceptScore W3201723912C126322002 @default.
- W3201723912 hasConceptScore W3201723912C184235292 @default.
- W3201723912 hasConceptScore W3201723912C2777658100 @default.
- W3201723912 hasConceptScore W3201723912C2779013556 @default.
- W3201723912 hasConceptScore W3201723912C502942594 @default.
- W3201723912 hasConceptScore W3201723912C71924100 @default.
- W3201723912 hasConceptScore W3201723912C76419328 @default.
- W3201723912 hasConceptScore W3201723912C86803240 @default.
- W3201723912 hasConceptScore W3201723912C90934575 @default.
- W3201723912 hasConceptScore W3201723912C95444343 @default.
- W3201723912 hasConceptScore W3201723912C97029542 @default.
- W3201723912 hasLocation W32017239121 @default.
- W3201723912 hasOpenAccess W3201723912 @default.
- W3201723912 hasPrimaryLocation W32017239121 @default.
- W3201723912 hasRelatedWork W2022589352 @default.
- W3201723912 hasRelatedWork W2154708791 @default.
- W3201723912 hasRelatedWork W2331606468 @default.
- W3201723912 hasRelatedWork W2337105312 @default.
- W3201723912 hasRelatedWork W2413189820 @default.
- W3201723912 hasRelatedWork W2623003466 @default.
- W3201723912 hasRelatedWork W2763237291 @default.
- W3201723912 hasRelatedWork W2918905756 @default.
- W3201723912 hasRelatedWork W2964433561 @default.
- W3201723912 hasRelatedWork W4361261034 @default.
- W3201723912 isParatext "false" @default.
- W3201723912 isRetracted "false" @default.
- W3201723912 magId "3201723912" @default.
- W3201723912 workType "article" @default.