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- W3201730861 endingPage "114388" @default.
- W3201730861 startingPage "114388" @default.
- W3201730861 abstract "Myocardial dysfunction in end stage cirrhotic liver disease, termed cirrhotic cardiomyopathy, is a long known, but little understood comorbidity seen in ∼50% of adults and children who present for liver transplantation. Structural, functional, hemodynamic and electrocardiographic aberrations that occur in the heart as a direct consequence of a damaged liver, is associated with multi-organ failure and increased mortality and morbidity in patients undergoing surgical procedures such as porto-systemic shunt placement and liver transplantation. Despite its clinical significance and rapid advances in science and pharmacotherapy, there is yet no specific treatment for this disease. This may be due to a lack of understanding of the pathogenesis and mechanisms behind how a cirrhotic liver causes cardiac pathology. This review will focus specifically on insights into the molecular mechanisms that drive this liver-heart interaction. Deeper understanding of the etio-pathogenesis of cirrhotic cardiomyopathy will allow us to design and test treatments that can be targeted to prevent and/or reverse this co-morbid consequence of liver failure and improve health care delivery and outcomes in patients with cirrhosis." @default.
- W3201730861 created "2021-10-11" @default.
- W3201730861 creator A5001870974 @default.
- W3201730861 date "2022-01-01" @default.
- W3201730861 modified "2023-10-06" @default.
- W3201730861 title "Mechanistic insights into the pathophysiology of cirrhotic cardiomyopathy" @default.
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