FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201731844> ?p ?o ?g. }

• W3201731844 abstract "Alcoholic liver disease (ALD) is one of the leading causes of morbidity among adults with alcohol use disorder (AUD) worldwide. Its clinical course ranges from steatosis to alcoholic hepatitis, progressing to more severe forms of liver damage, such as cirrhosis and hepatocellular carcinoma. The pathogenesis of ALD is complex and diverse elements are involved in its development, including environmental factors, genetic predisposition, the immune response, and the gut-liver axis interaction. Chronic alcohol consumption induces changes in gut microbiota that are associated with a loss of intestinal barrier function and inflammatory responses which reinforce a liver damage progression triggered by alcohol. Alcohol metabolites such as acetaldehyde, lipid peroxidation-derived aldehyde malondialdehyde (MDA), and protein-adducts act as liver-damaging hepatotoxins and potentiate systemic inflammation. Additionally, ethanol causes direct damage to the central nervous system (CNS) by crossing the blood-brain barrier (BBB), provoking oxidative stress contributing to neuroinflammation. Overall, these processes have been associated with susceptibility to depression, anxiety, and alcohol craving in ALD. Recent evidence has shown that probiotics can reverse alcohol-induced changes of the microbiota and prevent ALD progression by restoring gut microbial composition. However, the impact of probiotics on alcohol consumption behavior has been less explored. Probiotics have been used to treat various conditions by restoring microbiota and decreasing systemic and CNS inflammation. The results of some studies suggest that probiotics might improve mental function in Alzheimer’s, autism spectrum disorder, and attenuated morphine analgesic tolerance. In this sense, it has been observed that gut microbiota composition alterations, as well as its modulation using probiotics, elicit changes in neurotransmitter signals in the brain, especially in the dopamine reward circuit. Consequently, it is not difficult to imagine that a probiotics-based complementary treatment to ALD might reduce disease progression mediated by lower alcohol consumption. This review aims to present an update of the pathophysiologic mechanism underlying the microbiota-gut-liver-brain axis in ALD, as well as to provide evidence supporting probiotic use as a complementary therapy to address alcohol consumption disorder and its consequences on liver damage." @default.
• W3201731844 created "2021-10-11" @default.
• W3201731844 creator A5014064419 @default.
• W3201731844 creator A5019305946 @default.
• W3201731844 creator A5021169048 @default.
• W3201731844 creator A5042686641 @default.
• W3201731844 creator A5065911327 @default.
• W3201731844 creator A5005139914 @default.
• W3201731844 date "2021-09-24" @default.
• W3201731844 modified "2023-10-17" @default.
• W3201731844 title "Probiotics-Based Treatment as an Integral Approach for Alcohol Use Disorder in Alcoholic Liver Disease" @default.
• W3201731844 cites W109431680 @default.
• W3201731844 cites W14199531 @default.
• W3201731844 cites W1456504179 @default.
• W3201731844 cites W1510797412 @default.
• W3201731844 cites W165529560 @default.
• W3201731844 cites W1761714741 @default.
• W3201731844 cites W1893993890 @default.
• W3201731844 cites W1967747608 @default.
• W3201731844 cites W1968082302 @default.
• W3201731844 cites W1968465136 @default.
• W3201731844 cites W1969579498 @default.
• W3201731844 cites W1970535623 @default.
• W3201731844 cites W1970586330 @default.
• W3201731844 cites W1975931952 @default.
• W3201731844 cites W1978589950 @default.
• W3201731844 cites W1980844720 @default.
• W3201731844 cites W1983347814 @default.
• W3201731844 cites W1983412442 @default.
• W3201731844 cites W1992804695 @default.
• W3201731844 cites W1995744610 @default.
• W3201731844 cites W1999958782 @default.
• W3201731844 cites W2004243143 @default.
• W3201731844 cites W2034801500 @default.
• W3201731844 cites W2042027308 @default.
• W3201731844 cites W2043348459 @default.
• W3201731844 cites W2044238207 @default.
• W3201731844 cites W2046444990 @default.
• W3201731844 cites W2048375149 @default.
• W3201731844 cites W2048533116 @default.
• W3201731844 cites W2050082668 @default.
• W3201731844 cites W2053422932 @default.
• W3201731844 cites W2058578514 @default.
• W3201731844 cites W2063376552 @default.
• W3201731844 cites W2066848874 @default.
• W3201731844 cites W2068646907 @default.
• W3201731844 cites W2083207745 @default.
• W3201731844 cites W2089612575 @default.
• W3201731844 cites W2090964375 @default.
• W3201731844 cites W2091007197 @default.
• W3201731844 cites W2093437371 @default.
• W3201731844 cites W2104492171 @default.
• W3201731844 cites W2109000845 @default.
• W3201731844 cites W2139166152 @default.
• W3201731844 cites W2141757671 @default.
• W3201731844 cites W2147091482 @default.
• W3201731844 cites W2155821701 @default.
• W3201731844 cites W2158364865 @default.
• W3201731844 cites W2160939065 @default.
• W3201731844 cites W2162992969 @default.
• W3201731844 cites W2171724663 @default.
• W3201731844 cites W2181249084 @default.
• W3201731844 cites W2211876558 @default.
• W3201731844 cites W2228571342 @default.
• W3201731844 cites W2259551399 @default.
• W3201731844 cites W2399464963 @default.
• W3201731844 cites W2400858836 @default.
• W3201731844 cites W2460486405 @default.
• W3201731844 cites W2542111577 @default.
• W3201731844 cites W2619680342 @default.
• W3201731844 cites W2624145942 @default.
• W3201731844 cites W2753788435 @default.
• W3201731844 cites W2807598220 @default.
• W3201731844 cites W2889413110 @default.
• W3201731844 cites W2892048144 @default.
• W3201731844 cites W2899481836 @default.
• W3201731844 cites W2900706898 @default.
• W3201731844 cites W2903620554 @default.
• W3201731844 cites W2911082440 @default.
• W3201731844 cites W2911143260 @default.
• W3201731844 cites W2920959640 @default.
• W3201731844 cites W2951182767 @default.
• W3201731844 cites W2985397795 @default.
• W3201731844 cites W3000139667 @default.
• W3201731844 cites W3011404172 @default.
• W3201731844 cites W3036201198 @default.
• W3201731844 cites W3047020490 @default.
• W3201731844 cites W3049658547 @default.
• W3201731844 cites W3093471577 @default.
• W3201731844 cites W3118377679 @default.
• W3201731844 cites W3127516386 @default.
• W3201731844 cites W3129020037 @default.
• W3201731844 cites W3136863298 @default.
• W3201731844 doi "https://doi.org/10.3389/fphar.2021.729950" @default.
• W3201731844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8497569" @default.
• W3201731844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34630107" @default.
• W3201731844 hasPublicationYear "2021" @default.
• W3201731844 type Work @default.
• W3201731844 sameAs 3201731844 @default.
• W3201731844 citedByCount "14" @default.

• next