Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201732643> ?p ?o ?g. }
- W3201732643 endingPage "183" @default.
- W3201732643 startingPage "171" @default.
- W3201732643 abstract "In order to explore the role of forkhead box protein O1 (FoxO1) in the lipid metabolism and cell proliferation, goose primary hepatocytes were isolated and incubated with insulin or PI3K-Akt-mTOR pathway dual inhibitor NVP-BEZ235, and then transfected with FoxO1 interference plasmid. The related parameters of lipid metabolism and cell proliferation were measured. The results firstly showed that FoxO1 interference increased the intracellular TG and lipids concentration (P < 0.05); and increased the proliferative index (PI), cell DNA synthesis, protein expression of Cyclin D1 in goose primary hepatocytes (P < 0.05). Secondly, the co-treatment of insulin and FoxO1 interference increased the mRNA level and protein content of Cyclin D1 (P < 0.05); however, there was no significant difference between the insulin treatment and the co-treatment of insulin and miR-FoxO1 interference in the intracellular TG and lipids concentration and PI (P > 0.05). Lastly, the decrease of intracellular TG and lipids concentration and PI induced by NVP-BEZ235 was up-regulated by FoxO1 interference significantly (P < 0.05). In summary, FoxO1 could regulate the lipids metabolism and cell proliferation mediated by PI3K-Akt-mTOR signaling pathway in goose primary hepatocytes. Further investigations are required to highlight the potential role of FoxO1 in the lipid metabolism and cell proliferation mediated by insulin in goose primary hepatocyte." @default.
- W3201732643 created "2021-10-11" @default.
- W3201732643 creator A5013120307 @default.
- W3201732643 creator A5029173430 @default.
- W3201732643 creator A5033609112 @default.
- W3201732643 creator A5044146672 @default.
- W3201732643 creator A5045117548 @default.
- W3201732643 creator A5047632862 @default.
- W3201732643 creator A5058564791 @default.
- W3201732643 creator A5064564309 @default.
- W3201732643 creator A5088793267 @default.
- W3201732643 creator A5090603892 @default.
- W3201732643 date "2022-01-01" @default.
- W3201732643 modified "2023-09-25" @default.
- W3201732643 title "Forkhead box protein O1 (FoxO1) regulates lipids metabolism and cell proliferation mediated by insulin and PI3K-Akt-mTOR pathway in goose primary hepatocytes" @default.
- W3201732643 cites W1490154674 @default.
- W3201732643 cites W1607709290 @default.
- W3201732643 cites W1964801445 @default.
- W3201732643 cites W1977397361 @default.
- W3201732643 cites W1990556400 @default.
- W3201732643 cites W1990736019 @default.
- W3201732643 cites W2032294394 @default.
- W3201732643 cites W2039196160 @default.
- W3201732643 cites W2051781840 @default.
- W3201732643 cites W2062643691 @default.
- W3201732643 cites W2077649854 @default.
- W3201732643 cites W2078584863 @default.
- W3201732643 cites W2107277218 @default.
- W3201732643 cites W2166961310 @default.
- W3201732643 cites W2304097507 @default.
- W3201732643 cites W2309809352 @default.
- W3201732643 cites W2315147869 @default.
- W3201732643 cites W2515025211 @default.
- W3201732643 cites W2518669575 @default.
- W3201732643 cites W2560302529 @default.
- W3201732643 cites W2780698132 @default.
- W3201732643 cites W2800613300 @default.
- W3201732643 cites W2805815575 @default.
- W3201732643 cites W2901432198 @default.
- W3201732643 cites W2916124248 @default.
- W3201732643 cites W2928664607 @default.
- W3201732643 cites W2936238422 @default.
- W3201732643 cites W2944276385 @default.
- W3201732643 cites W2944639502 @default.
- W3201732643 cites W2953602670 @default.
- W3201732643 cites W2969897457 @default.
- W3201732643 cites W2975355006 @default.
- W3201732643 cites W2990297807 @default.
- W3201732643 cites W2992830315 @default.
- W3201732643 cites W2994215837 @default.
- W3201732643 cites W2997947525 @default.
- W3201732643 cites W3006004734 @default.
- W3201732643 cites W3011537607 @default.
- W3201732643 cites W3021975140 @default.
- W3201732643 cites W3024353547 @default.
- W3201732643 cites W3037767747 @default.
- W3201732643 cites W3084131773 @default.
- W3201732643 cites W3092713577 @default.
- W3201732643 doi "https://doi.org/10.32604/biocell.2022.015409" @default.
- W3201732643 hasPublicationYear "2022" @default.
- W3201732643 type Work @default.
- W3201732643 sameAs 3201732643 @default.
- W3201732643 citedByCount "1" @default.
- W3201732643 countsByYear W32017326432023 @default.
- W3201732643 crossrefType "journal-article" @default.
- W3201732643 hasAuthorship W3201732643A5013120307 @default.
- W3201732643 hasAuthorship W3201732643A5029173430 @default.
- W3201732643 hasAuthorship W3201732643A5033609112 @default.
- W3201732643 hasAuthorship W3201732643A5044146672 @default.
- W3201732643 hasAuthorship W3201732643A5045117548 @default.
- W3201732643 hasAuthorship W3201732643A5047632862 @default.
- W3201732643 hasAuthorship W3201732643A5058564791 @default.
- W3201732643 hasAuthorship W3201732643A5064564309 @default.
- W3201732643 hasAuthorship W3201732643A5088793267 @default.
- W3201732643 hasAuthorship W3201732643A5090603892 @default.
- W3201732643 hasBestOaLocation W32017326431 @default.
- W3201732643 hasConcept C112446052 @default.
- W3201732643 hasConcept C126322002 @default.
- W3201732643 hasConcept C134018914 @default.
- W3201732643 hasConcept C140149449 @default.
- W3201732643 hasConcept C1491633281 @default.
- W3201732643 hasConcept C185592680 @default.
- W3201732643 hasConcept C199835354 @default.
- W3201732643 hasConcept C202751555 @default.
- W3201732643 hasConcept C2776200302 @default.
- W3201732643 hasConcept C2777391703 @default.
- W3201732643 hasConcept C2779306644 @default.
- W3201732643 hasConcept C29537977 @default.
- W3201732643 hasConcept C4733338 @default.
- W3201732643 hasConcept C55493867 @default.
- W3201732643 hasConcept C62112901 @default.
- W3201732643 hasConcept C62478195 @default.
- W3201732643 hasConcept C71924100 @default.
- W3201732643 hasConcept C75217442 @default.
- W3201732643 hasConcept C79879829 @default.
- W3201732643 hasConcept C86554907 @default.
- W3201732643 hasConcept C86803240 @default.
- W3201732643 hasConcept C95444343 @default.