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• W3201737623 abstract "Neurophysiological studies depend on a reliable quantification of whether and when a neuron responds to stimulation. Simple methods to determine responsiveness require arbitrary parameter choices, such as binning size, while more advanced model-based methods require fitting and hyperparameter tuning. These parameter choices can change the results, which invites bad statistical practice and reduces the replicability. New recording techniques that yield increasingly large numbers of cells would benefit from a test for cell-inclusion that requires no manual curation. Here, we present the parameter-free ZETA-test, which outperforms t-tests, ANOVAs, and renewal-process-based methods by including more cells at a similar false-positive rate. We show that our procedure works across brain regions and recording techniques, including calcium imaging and Neuropixels data. Furthermore, in illustration of the method, we show in mouse visual cortex that (1) visuomotor-mismatch and spatial location are encoded by different neuronal subpopulations and (2) optogenetic stimulation of VIP cells leads to early inhibition and subsequent disinhibition." @default.
• W3201737623 created "2021-10-11" @default.
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• W3201737623 date "2021-09-27" @default.
• W3201737623 modified "2023-10-16" @default.
• W3201737623 title "A parameter-free statistical test for neuronal responsiveness" @default.
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• W3201737623 doi "https://doi.org/10.7554/elife.71969" @default.
• W3201737623 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8626082" @default.
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• W3201737623 hasPublicationYear "2021" @default.
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