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• W3201748403 abstract "Abstract Background With increasing number of clinical trials relating to fecal microbiota transplantation (FMT), it is crucial to identify and recruit long‐term, healthy, and regular fecal donors. Objective We aimed to report the outcomes of screening and recruitment of fecal donors for FMT. Methods Potential donors were recruited via advertisement through internal mass emails at a university. They were required to undergo a pre‐screening telephone interview, a detailed questionnaire, followed by blood and stool investigations. Results From January 2017 to December 2020, 119 potential donors were assessed with 75 failed pre‐screening. Reasons for failure included: inability to come back for regular and long‐term donation ( n = 19), high body mass index ( n = 17), underlying chronic illness or on long‐term medications ( n = 11), being healthcare professionals ( n = 10), use of antibiotics within 3 months ( n = 5) and others ( n = 13). Forty‐four donors completed questionnaires and 11 did not fulfill the clinical criteria. Of the remaining 33 potential donors who had stool and blood tests, 21 failed stool investigations (19 extended‐spectrum beta‐lactamase [ESBL] organisms, one Clostridioides difficile , one C. difficile plus Methicillin Resistant Staphylococcus aureus ), one failed blood tests (high serum alkaline phosphatase level), one required long‐term medication and nine withdrew consent and/or lost to follow‐up. In total, only one out of 119 (0.8%) potential donors was successfully recruited as a regular donor. Conclusion There was a high failure rate in donor screening for FMT. Main reasons for screening failure included high prevalence of positive ESBL organisms in stool and failed commitment to regular stool donation." @default.
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• W3201748403 date "2021-10-08" @default.
• W3201748403 modified "2023-10-01" @default.
• W3201748403 title "High prevalence of extended‐spectrum beta‐lactamase organisms and the COVID‐19 pandemic impact on donor recruitment for fecal microbiota transplantation in Hong Kong" @default.
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• W3201748403 doi "https://doi.org/10.1002/ueg2.12160" @default.
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