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- W3201757249 abstract "The gut microbiome (GM) has emerged as a key factor in the genesis and progression of many diseases. The intestinal bacterial composition also influences treatment-related side effects and even the efficacy of oncological therapies. Acute leukemia (AL) is the most common cancer among children and the most frequent cause of cancer-related death during childhood. Outcomes have improved considerably over the past 4 decades, with the current long-term survival for acute lymphoblastic leukemia being ∼90%. However, several acute toxicities and long-term sequelae are associated with the multimodal therapy protocols applied in these patients. Specific GM configurations could contribute to the multistep developmental hypothesis for leukemogenesis. Moreover, GM alterations occur during the AL therapeutic course and are associated with treatment-related complications, especially during hematopoietic stem cell transplantation. The GM perturbation could last even after the removal of microbiome-modifying factors, like antibiotics, chemotherapeutic drugs, or alloimmune reactions, contributing to several health-related issues in AL survivors. The purpose of this article is to provide a comprehensive review of the chronological changes of GM in children with AL, from predisposition to cure. The underpinning biological processes and the potential interventions to modulate the GM toward a potentially health-promoting configuration are also highlighted." @default.
- W3201757249 created "2021-10-11" @default.
- W3201757249 creator A5003684141 @default.
- W3201757249 creator A5010291224 @default.
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- W3201757249 creator A5052399561 @default.
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- W3201757249 creator A5065673637 @default.
- W3201757249 creator A5074034025 @default.
- W3201757249 creator A5087582879 @default.
- W3201757249 date "2021-11-16" @default.
- W3201757249 modified "2023-09-27" @default.
- W3201757249 title "Gut microbiome in pediatric acute leukemia: from predisposition to cure" @default.
- W3201757249 cites W1801876107 @default.
- W3201757249 cites W1984614343 @default.
- W3201757249 cites W2004291756 @default.
- W3201757249 cites W2005788065 @default.
- W3201757249 cites W2012105775 @default.
- W3201757249 cites W2032157446 @default.
- W3201757249 cites W2051646706 @default.
- W3201757249 cites W2059128083 @default.
- W3201757249 cites W2081653606 @default.
- W3201757249 cites W2090222259 @default.
- W3201757249 cites W2103867989 @default.
- W3201757249 cites W2121411489 @default.
- W3201757249 cites W2149074973 @default.
- W3201757249 cites W2149573313 @default.
- W3201757249 cites W2153820933 @default.
- W3201757249 cites W2178468712 @default.
- W3201757249 cites W2262897529 @default.
- W3201757249 cites W2287336102 @default.
- W3201757249 cites W2339583198 @default.
- W3201757249 cites W2407774696 @default.
- W3201757249 cites W2471996917 @default.
- W3201757249 cites W2513069645 @default.
- W3201757249 cites W2563720483 @default.
- W3201757249 cites W2587332109 @default.
- W3201757249 cites W2589011865 @default.
- W3201757249 cites W2598457132 @default.
- W3201757249 cites W2603640008 @default.
- W3201757249 cites W2605654758 @default.
- W3201757249 cites W2625068954 @default.
- W3201757249 cites W2625969065 @default.
- W3201757249 cites W2627092521 @default.
- W3201757249 cites W2735500813 @default.
- W3201757249 cites W2742423499 @default.
- W3201757249 cites W2749612575 @default.
- W3201757249 cites W2753679312 @default.
- W3201757249 cites W2758502959 @default.
- W3201757249 cites W2763699940 @default.
- W3201757249 cites W2786278201 @default.
- W3201757249 cites W2790971321 @default.
- W3201757249 cites W2793191999 @default.
- W3201757249 cites W2804265396 @default.
- W3201757249 cites W2806980256 @default.
- W3201757249 cites W2884424911 @default.
- W3201757249 cites W2887509155 @default.
- W3201757249 cites W2899182140 @default.
- W3201757249 cites W2912227533 @default.
- W3201757249 cites W2915484156 @default.
- W3201757249 cites W2917116014 @default.
- W3201757249 cites W2922175623 @default.
- W3201757249 cites W2934530260 @default.
- W3201757249 cites W2940911218 @default.
- W3201757249 cites W2948160364 @default.
- W3201757249 cites W2949126864 @default.
- W3201757249 cites W2961799927 @default.
- W3201757249 cites W2968020594 @default.
- W3201757249 cites W2970428830 @default.
- W3201757249 cites W2970919380 @default.
- W3201757249 cites W2972909756 @default.
- W3201757249 cites W2981496133 @default.
- W3201757249 cites W2982566732 @default.
- W3201757249 cites W2984945573 @default.
- W3201757249 cites W2987760949 @default.
- W3201757249 cites W2990284475 @default.
- W3201757249 cites W2990824191 @default.
- W3201757249 cites W2992032748 @default.
- W3201757249 cites W3002031918 @default.
- W3201757249 cites W3007732383 @default.
- W3201757249 cites W3008229386 @default.
- W3201757249 cites W3009219729 @default.
- W3201757249 cites W3012577142 @default.
- W3201757249 cites W3014584966 @default.
- W3201757249 cites W3015523491 @default.
- W3201757249 cites W3026872839 @default.
- W3201757249 cites W3035036220 @default.
- W3201757249 cites W3040245690 @default.
- W3201757249 cites W3086420584 @default.
- W3201757249 cites W3087184338 @default.
- W3201757249 cites W3089831531 @default.
- W3201757249 cites W3092313937 @default.
- W3201757249 cites W3093193897 @default.
- W3201757249 cites W3107153021 @default.
- W3201757249 cites W3115108242 @default.
- W3201757249 cites W3119807729 @default.
- W3201757249 cites W3122676222 @default.
- W3201757249 cites W3125639254 @default.