FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201760746> ?p ?o ?g. }

• W3201760746 endingPage "816" @default.
• W3201760746 startingPage "809" @default.
• W3201760746 abstract "Glucokinase (GCK) regulates insulin secretion and hepatic glucose metabolism, and its inactivating variants could cause diabetes. We aimed to evaluate the association of a low-frequency variant of GCK (rs13306393) with type 2 diabetes (T2D), prediabetes, or both (impaired glucose regulation [IGR]) in a Chinese population. An association study was first conducted in a random cluster sampling population (sample 1: 537 T2D, 768 prediabetes, and 1,912 control), and then another independent population (sample 2: 3,896 T2D, 2,301 prediabetes, and 868 control) was used to confirm the findings in sample 1. The A allele of rs13306393 was associated with T2D (odds ratio 3.08 [95% CI 1.77–5.36], P = 0.00007) in sample 1; rs13306393 was also associated with prediabetes (1.67 [1.05–2.65], P = 0.03) in sample 2. In a pooled analysis of the two samples, the A allele increased the risk of T2D (1.57 [1.15–2.15], P = 0.005), prediabetes (1.83 [1.33–2.54], P = 0.0003) or IGR (1.68 [1.26–2.25], P = 0.0004), insulin resistance estimated by HOMA (β = 0.043, P = 0.001), HbA1c (β = 0.029, P = 0.029), and urinary albumin excretion (β = 0.033, P = 0.025), irrespective of age, sex, and BMI. Thus, the Chinese-specific low-frequency variant increased the risk of T2D through reducing insulin sensitivity rather than islet β-cell function, which should be considered in the clinical use of GCK activators in the future." @default.
• W3201760746 created "2021-10-11" @default.
• W3201760746 creator A5000693667 @default.
• W3201760746 creator A5005275890 @default.
• W3201760746 creator A5005974139 @default.
• W3201760746 creator A5008962800 @default.
• W3201760746 creator A5016535219 @default.
• W3201760746 creator A5018058348 @default.
• W3201760746 creator A5023104005 @default.
• W3201760746 creator A5028028356 @default.
• W3201760746 creator A5034169829 @default.
• W3201760746 creator A5037666565 @default.
• W3201760746 creator A5041914033 @default.
• W3201760746 creator A5054525661 @default.
• W3201760746 creator A5071037763 @default.
• W3201760746 creator A5071824771 @default.
• W3201760746 creator A5073819037 @default.
• W3201760746 creator A5075388616 @default.
• W3201760746 creator A5081738034 @default.
• W3201760746 date "2020-12-09" @default.
• W3201760746 modified "2023-09-23" @default.
• W3201760746 title "Low-Frequency Genetic Variant in the Hepatic Glucokinase Gene Is Associated With Type 2 Diabetes and Insulin Resistance in Chinese Population" @default.
• W3201760746 cites W1583389637 @default.
• W3201760746 cites W1935567550 @default.
• W3201760746 cites W1974479380 @default.
• W3201760746 cites W1988454200 @default.
• W3201760746 cites W2048755332 @default.
• W3201760746 cites W2072185982 @default.
• W3201760746 cites W2096380706 @default.
• W3201760746 cites W2118615260 @default.
• W3201760746 cites W2125112711 @default.
• W3201760746 cites W2128934212 @default.
• W3201760746 cites W2130266732 @default.
• W3201760746 cites W2141698109 @default.
• W3201760746 cites W2160234571 @default.
• W3201760746 cites W2165019590 @default.
• W3201760746 cites W2314164298 @default.
• W3201760746 cites W2325832504 @default.
• W3201760746 cites W2892237363 @default.
• W3201760746 cites W3045623812 @default.
• W3201760746 doi "https://doi.org/10.2337/db20-0564" @default.
• W3201760746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33298402" @default.
• W3201760746 hasPublicationYear "2020" @default.
• W3201760746 type Work @default.
• W3201760746 sameAs 3201760746 @default.
• W3201760746 citedByCount "3" @default.
• W3201760746 countsByYear W32017607462021 @default.
• W3201760746 countsByYear W32017607462023 @default.
• W3201760746 crossrefType "journal-article" @default.
• W3201760746 hasAuthorship W3201760746A5000693667 @default.
• W3201760746 hasAuthorship W3201760746A5005275890 @default.
• W3201760746 hasAuthorship W3201760746A5005974139 @default.
• W3201760746 hasAuthorship W3201760746A5008962800 @default.
• W3201760746 hasAuthorship W3201760746A5016535219 @default.
• W3201760746 hasAuthorship W3201760746A5018058348 @default.
• W3201760746 hasAuthorship W3201760746A5023104005 @default.
• W3201760746 hasAuthorship W3201760746A5028028356 @default.
• W3201760746 hasAuthorship W3201760746A5034169829 @default.
• W3201760746 hasAuthorship W3201760746A5037666565 @default.
• W3201760746 hasAuthorship W3201760746A5041914033 @default.
• W3201760746 hasAuthorship W3201760746A5054525661 @default.
• W3201760746 hasAuthorship W3201760746A5071037763 @default.
• W3201760746 hasAuthorship W3201760746A5071824771 @default.
• W3201760746 hasAuthorship W3201760746A5073819037 @default.
• W3201760746 hasAuthorship W3201760746A5075388616 @default.
• W3201760746 hasAuthorship W3201760746A5081738034 @default.
• W3201760746 hasBestOaLocation W32017607461 @default.
• W3201760746 hasConcept C104317684 @default.
• W3201760746 hasConcept C126322002 @default.
• W3201760746 hasConcept C134018914 @default.
• W3201760746 hasConcept C156957248 @default.
• W3201760746 hasConcept C180754005 @default.
• W3201760746 hasConcept C2777180221 @default.
• W3201760746 hasConcept C2777185836 @default.
• W3201760746 hasConcept C2777391703 @default.
• W3201760746 hasConcept C2779306644 @default.
• W3201760746 hasConcept C2779668308 @default.
• W3201760746 hasConcept C2780609358 @default.
• W3201760746 hasConcept C2908647359 @default.
• W3201760746 hasConcept C37463918 @default.
• W3201760746 hasConcept C54355233 @default.
• W3201760746 hasConcept C555293320 @default.
• W3201760746 hasConcept C71924100 @default.
• W3201760746 hasConcept C86803240 @default.
• W3201760746 hasConcept C98335778 @default.
• W3201760746 hasConcept C99454951 @default.
• W3201760746 hasConceptScore W3201760746C104317684 @default.
• W3201760746 hasConceptScore W3201760746C126322002 @default.
• W3201760746 hasConceptScore W3201760746C134018914 @default.
• W3201760746 hasConceptScore W3201760746C156957248 @default.
• W3201760746 hasConceptScore W3201760746C180754005 @default.
• W3201760746 hasConceptScore W3201760746C2777180221 @default.
• W3201760746 hasConceptScore W3201760746C2777185836 @default.
• W3201760746 hasConceptScore W3201760746C2777391703 @default.
• W3201760746 hasConceptScore W3201760746C2779306644 @default.
• W3201760746 hasConceptScore W3201760746C2779668308 @default.
• W3201760746 hasConceptScore W3201760746C2780609358 @default.
• W3201760746 hasConceptScore W3201760746C2908647359 @default.

• next