Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201769314> ?p ?o ?g. }
- W3201769314 endingPage "10683" @default.
- W3201769314 startingPage "10683" @default.
- W3201769314 abstract "With no lysine (K) (WNK) kinases comprise a family of serine/threonine kinases belonging to an evolutionary branch of the eukaryotic kinome. These special kinases contain a unique active site and are found in a wide range of eukaryotes. The model plant Arabidopsis has been reported to have 11 WNK members, of which WNK8 functions as a negative regulator of abscisic acid (ABA) signaling. Here, we found that the expression of WNK8 is post-transcriptionally regulated through an upstream open reading frame (uORF) found in its 5' untranslated region (5'-UTR). This uORF has been predicted to encode a conserved peptide named CPuORF58 in both monocotyledons and dicotyledons. The analysis of the published ribosome footprinting studies and the study of the frameshift CPuORF58 peptide with altered repression capability suggested that this uORF causes ribosome stalling. Plants transformed with the native WNK8 promoter driving WNK8 expression were comparable with wild-type plants, whereas the plants transformed with a similar construct with mutated CPuORF58 start codon were less sensitive to ABA. In addition, WNK8 and its downstream target RACK1 were found to synergistically coordinate ABA signaling rather than antagonistically modulating glucose response and flowering in plants. Collectively, these results suggest that the WNK8 expression must be tightly regulated to fulfill the demands of ABA response in plants." @default.
- W3201769314 created "2021-10-11" @default.
- W3201769314 creator A5030019815 @default.
- W3201769314 creator A5037305789 @default.
- W3201769314 creator A5042251752 @default.
- W3201769314 creator A5049328355 @default.
- W3201769314 date "2021-10-01" @default.
- W3201769314 modified "2023-10-17" @default.
- W3201769314 title "Upstream Open Reading Frame Mediated Translation of WNK8 Is Required for ABA Response in Arabidopsis" @default.
- W3201769314 cites W1578118711 @default.
- W3201769314 cites W1634117501 @default.
- W3201769314 cites W1976823819 @default.
- W3201769314 cites W1976937093 @default.
- W3201769314 cites W1985710176 @default.
- W3201769314 cites W1988472050 @default.
- W3201769314 cites W2000703421 @default.
- W3201769314 cites W2001118852 @default.
- W3201769314 cites W2008270956 @default.
- W3201769314 cites W2027195993 @default.
- W3201769314 cites W2030576127 @default.
- W3201769314 cites W2030855369 @default.
- W3201769314 cites W2038027259 @default.
- W3201769314 cites W2040053047 @default.
- W3201769314 cites W2043060551 @default.
- W3201769314 cites W2050875396 @default.
- W3201769314 cites W2060755593 @default.
- W3201769314 cites W2064315488 @default.
- W3201769314 cites W2079156404 @default.
- W3201769314 cites W2079517684 @default.
- W3201769314 cites W2084727430 @default.
- W3201769314 cites W2096441854 @default.
- W3201769314 cites W2101380365 @default.
- W3201769314 cites W2104916016 @default.
- W3201769314 cites W2105652311 @default.
- W3201769314 cites W2107358584 @default.
- W3201769314 cites W2108130533 @default.
- W3201769314 cites W2108244474 @default.
- W3201769314 cites W2111653375 @default.
- W3201769314 cites W2113583125 @default.
- W3201769314 cites W2115242242 @default.
- W3201769314 cites W2116122104 @default.
- W3201769314 cites W2116167965 @default.
- W3201769314 cites W2128621883 @default.
- W3201769314 cites W2135152144 @default.
- W3201769314 cites W2137015675 @default.
- W3201769314 cites W2141617464 @default.
- W3201769314 cites W2141641006 @default.
- W3201769314 cites W2142766228 @default.
- W3201769314 cites W2152974197 @default.
- W3201769314 cites W2160018480 @default.
- W3201769314 cites W2168138973 @default.
- W3201769314 cites W2172151601 @default.
- W3201769314 cites W2344817000 @default.
- W3201769314 cites W2427010553 @default.
- W3201769314 cites W2580035316 @default.
- W3201769314 cites W2593687001 @default.
- W3201769314 cites W2616130684 @default.
- W3201769314 cites W2626494417 @default.
- W3201769314 cites W2758457673 @default.
- W3201769314 cites W2886810956 @default.
- W3201769314 cites W2903681629 @default.
- W3201769314 cites W2913104203 @default.
- W3201769314 cites W2953415341 @default.
- W3201769314 cites W2982304524 @default.
- W3201769314 cites W2983491299 @default.
- W3201769314 cites W3009229284 @default.
- W3201769314 cites W3012068569 @default.
- W3201769314 cites W3012319475 @default.
- W3201769314 cites W3027980964 @default.
- W3201769314 cites W3154294730 @default.
- W3201769314 doi "https://doi.org/10.3390/ijms221910683" @default.
- W3201769314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8509022" @default.
- W3201769314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34639024" @default.
- W3201769314 hasPublicationYear "2021" @default.
- W3201769314 type Work @default.
- W3201769314 sameAs 3201769314 @default.
- W3201769314 citedByCount "3" @default.
- W3201769314 countsByYear W32017693142022 @default.
- W3201769314 countsByYear W32017693142023 @default.
- W3201769314 crossrefType "journal-article" @default.
- W3201769314 hasAuthorship W3201769314A5030019815 @default.
- W3201769314 hasAuthorship W3201769314A5037305789 @default.
- W3201769314 hasAuthorship W3201769314A5042251752 @default.
- W3201769314 hasAuthorship W3201769314A5049328355 @default.
- W3201769314 hasBestOaLocation W32017693141 @default.
- W3201769314 hasConcept C104317684 @default.
- W3201769314 hasConcept C105580179 @default.
- W3201769314 hasConcept C12464233 @default.
- W3201769314 hasConcept C143065580 @default.
- W3201769314 hasConcept C149364088 @default.
- W3201769314 hasConcept C166258313 @default.
- W3201769314 hasConcept C167625842 @default.
- W3201769314 hasConcept C2779491563 @default.
- W3201769314 hasConcept C2779591172 @default.
- W3201769314 hasConcept C47289529 @default.
- W3201769314 hasConcept C54355233 @default.
- W3201769314 hasConcept C86803240 @default.
- W3201769314 hasConcept C89604277 @default.