FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201786089> ?p ?o ?g. }

• W3201786089 endingPage "e045802" @default.
• W3201786089 startingPage "e045802" @default.
• W3201786089 abstract "A Low Glycaemic Index (LGI) diet is a proposed lifestyle intervention in non-alcoholic fatty liver diseases (NAFLD) which is designed to reduce circulating blood glucose levels, hepatic glucose influx, insulin resistance and de novo lipogenesis. A significant reduction in liver fat content through following a 1-week LGI diet has been reported in healthy volunteers. Changes in dietary fat and carbohydrates have also been shown to alter gut microbiota composition and lead to hepatic steatosis through the gut-liver axis. There are no available trials examining the effects of an LGI diet on liver fat accumulation in patients with NAFLD; nor has the impact of consuming an LGI diet on gut microbiota composition been studied in this population. The aim of this trial is to investigate the effects of LGI diet consumption on liver fat content and its effects on gut microbiota composition in participants with NAFLD compared with a High Glycaemic Index (HGI) control diet.A 2×2 cross-over randomised mechanistic dietary trial will allocate 16 participants with NAFLD to a 2-week either HGI or LGI diet followed by a 4-week wash-out period and then the LGI or HGI diet, alternative to that followed in the first 2 weeks. Baseline and postintervention (four visits) outcome measures will be collected to assess liver fat content (using MRI/S and controlled attenuation parameter-FibroScan), gut microbiota composition (using 16S RNA analysis) and blood biomarkers including glycaemic, insulinaemic, liver, lipid and haematological profiles, gut hormones levels and short-chain fatty acids.Study protocol has been approved by the ethics committees of The University of Nottingham and East Midlands Nottingham-2 Research Ethics Committee (REC reference 19/EM/0291). Data from this trial will be used as part of a Philosophy Doctorate thesis. Publications will be in peer-reviewed journals.NCT04415632." @default.
• W3201786089 created "2021-10-11" @default.
• W3201786089 creator A5007204344 @default.
• W3201786089 creator A5013797270 @default.
• W3201786089 creator A5017835223 @default.
• W3201786089 creator A5035193406 @default.
• W3201786089 creator A5072710616 @default.
• W3201786089 creator A5080982384 @default.
• W3201786089 creator A5084012349 @default.
• W3201786089 creator A5085160808 @default.
• W3201786089 date "2021-10-01" @default.
• W3201786089 modified "2023-10-16" @default.
• W3201786089 title "Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): a study protocol of an efficacy mechanism evaluation" @default.
• W3201786089 cites W1533229207 @default.
• W3201786089 cites W1798419543 @default.
• W3201786089 cites W1850860196 @default.
• W3201786089 cites W1861519250 @default.
• W3201786089 cites W1972686367 @default.
• W3201786089 cites W1972953907 @default.
• W3201786089 cites W1985296565 @default.
• W3201786089 cites W1998278062 @default.
• W3201786089 cites W2002719027 @default.
• W3201786089 cites W2004082972 @default.
• W3201786089 cites W2009170813 @default.
• W3201786089 cites W2018265574 @default.
• W3201786089 cites W2031821244 @default.
• W3201786089 cites W2032230795 @default.
• W3201786089 cites W2036817457 @default.
• W3201786089 cites W2044943696 @default.
• W3201786089 cites W2051587831 @default.
• W3201786089 cites W2056036338 @default.
• W3201786089 cites W2061853512 @default.
• W3201786089 cites W2067791097 @default.
• W3201786089 cites W2074759037 @default.
• W3201786089 cites W2076695574 @default.
• W3201786089 cites W2089046390 @default.
• W3201786089 cites W2095660555 @default.
• W3201786089 cites W2097783355 @default.
• W3201786089 cites W2101505804 @default.
• W3201786089 cites W2103139789 @default.
• W3201786089 cites W2103680156 @default.
• W3201786089 cites W2104890139 @default.
• W3201786089 cites W2127010382 @default.
• W3201786089 cites W2128092694 @default.
• W3201786089 cites W2133515635 @default.
• W3201786089 cites W2154184102 @default.
• W3201786089 cites W2154312373 @default.
• W3201786089 cites W2156821262 @default.
• W3201786089 cites W2157338541 @default.
• W3201786089 cites W2161332823 @default.
• W3201786089 cites W2166562121 @default.
• W3201786089 cites W2195637511 @default.
• W3201786089 cites W2210672989 @default.
• W3201786089 cites W2313423400 @default.
• W3201786089 cites W2343873418 @default.
• W3201786089 cites W2409656339 @default.
• W3201786089 cites W2511747037 @default.
• W3201786089 cites W2543316248 @default.
• W3201786089 cites W2563003202 @default.
• W3201786089 cites W2572855576 @default.
• W3201786089 cites W2593573738 @default.
• W3201786089 cites W2605052214 @default.
• W3201786089 cites W2608538847 @default.
• W3201786089 cites W2763014357 @default.
• W3201786089 cites W2765540680 @default.
• W3201786089 cites W2766846784 @default.
• W3201786089 cites W2767268548 @default.
• W3201786089 cites W2808457437 @default.
• W3201786089 cites W2810966177 @default.
• W3201786089 cites W2890116226 @default.
• W3201786089 cites W2895600813 @default.
• W3201786089 cites W2908524400 @default.
• W3201786089 cites W2923293530 @default.
• W3201786089 cites W2961407509 @default.
• W3201786089 cites W2970182432 @default.
• W3201786089 cites W2986860146 @default.
• W3201786089 cites W3003752356 @default.
• W3201786089 doi "https://doi.org/10.1136/bmjopen-2020-045802" @default.
• W3201786089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8499287" @default.
• W3201786089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34620653" @default.
• W3201786089 hasPublicationYear "2021" @default.
• W3201786089 type Work @default.
• W3201786089 sameAs 3201786089 @default.
• W3201786089 citedByCount "1" @default.
• W3201786089 countsByYear W32017860892023 @default.
• W3201786089 crossrefType "journal-article" @default.
• W3201786089 hasAuthorship W3201786089A5007204344 @default.
• W3201786089 hasAuthorship W3201786089A5013797270 @default.
• W3201786089 hasAuthorship W3201786089A5017835223 @default.
• W3201786089 hasAuthorship W3201786089A5035193406 @default.
• W3201786089 hasAuthorship W3201786089A5072710616 @default.
• W3201786089 hasAuthorship W3201786089A5080982384 @default.
• W3201786089 hasAuthorship W3201786089A5084012349 @default.
• W3201786089 hasAuthorship W3201786089A5085160808 @default.
• W3201786089 hasBestOaLocation W32017860891 @default.
• W3201786089 hasConcept C126322002 @default.
• W3201786089 hasConcept C134018914 @default.
• W3201786089 hasConcept C141359234 @default.

• next