FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201799293> ?p ?o ?g. }

• W3201799293 abstract "Various disease-related genes have recently been identified using single nucleotide polymorphisms (SNPs). This study identified disease-related genes by analyzing SNP using genomic DNA isolated from Japanese patients with periapical periodontitis. Results showed that the SNP in LRP5 demonstrated a significant genotypic association with periapical lesions (Fisher's exact test, P < 0.05). We constructed an in vivo murine periapical periodontitis model to confirm the Wnt/β-catenin signaling pathway's role in developing and healing periapical periodontitis. We observed that administration of the Wnt/β-catenin signaling pathway inhibitor enlarged the periapical lesion. Moreover, applying lithium chloride (LiCl) to root canals accelerated periapical periodontitis healing. Histological analysis demonstrated that the expression levels of Col1a1 and Runx2 increased in the LiCl application group compared to that in the control group. Furthermore, many CD45R-positive cells appeared in the periapical lesions in the LiCl application group. These results indicated that LiCl promoted the healing of periapical periodontitis by inducing bone formation and immune responses. Our findings suggest that the Wnt/β-catenin signaling pathway regulates the development of periapical periodontitis. We propose a bioactive next-generation root canal treatment agent for this dental lesion." @default.
• W3201799293 created "2021-10-11" @default.
• W3201799293 creator A5002869259 @default.
• W3201799293 creator A5011064134 @default.
• W3201799293 creator A5018676958 @default.
• W3201799293 creator A5034733482 @default.
• W3201799293 creator A5050686238 @default.
• W3201799293 creator A5069505342 @default.
• W3201799293 date "2021-10-04" @default.
• W3201799293 modified "2023-10-14" @default.
• W3201799293 title "The Wnt/β-catenin signaling pathway has a healing ability for periapical periodontitis" @default.
• W3201799293 cites W1548986596 @default.
• W3201799293 cites W1578516253 @default.
• W3201799293 cites W1875277064 @default.
• W3201799293 cites W1974595623 @default.
• W3201799293 cites W1978178792 @default.
• W3201799293 cites W2019196925 @default.
• W3201799293 cites W2021854879 @default.
• W3201799293 cites W2027381107 @default.
• W3201799293 cites W2038180649 @default.
• W3201799293 cites W2043880243 @default.
• W3201799293 cites W2045733730 @default.
• W3201799293 cites W2054077079 @default.
• W3201799293 cites W2061981944 @default.
• W3201799293 cites W2072691881 @default.
• W3201799293 cites W2073708654 @default.
• W3201799293 cites W2081590894 @default.
• W3201799293 cites W2090178061 @default.
• W3201799293 cites W2090219665 @default.
• W3201799293 cites W2101889783 @default.
• W3201799293 cites W2105866363 @default.
• W3201799293 cites W2111302020 @default.
• W3201799293 cites W2124095779 @default.
• W3201799293 cites W2160180203 @default.
• W3201799293 cites W2298777399 @default.
• W3201799293 cites W2512090892 @default.
• W3201799293 cites W2518451283 @default.
• W3201799293 cites W2621361823 @default.
• W3201799293 cites W2621492659 @default.
• W3201799293 cites W3138227475 @default.
• W3201799293 doi "https://doi.org/10.1038/s41598-021-99231-x" @default.
• W3201799293 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8490427" @default.
• W3201799293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34608236" @default.
• W3201799293 hasPublicationYear "2021" @default.
• W3201799293 type Work @default.
• W3201799293 sameAs 3201799293 @default.
• W3201799293 citedByCount "7" @default.
• W3201799293 countsByYear W32017992932022 @default.
• W3201799293 countsByYear W32017992932023 @default.
• W3201799293 crossrefType "journal-article" @default.
• W3201799293 hasAuthorship W3201799293A5002869259 @default.
• W3201799293 hasAuthorship W3201799293A5011064134 @default.
• W3201799293 hasAuthorship W3201799293A5018676958 @default.
• W3201799293 hasAuthorship W3201799293A5034733482 @default.
• W3201799293 hasAuthorship W3201799293A5050686238 @default.
• W3201799293 hasAuthorship W3201799293A5069505342 @default.
• W3201799293 hasBestOaLocation W32017992931 @default.
• W3201799293 hasConcept C126322002 @default.
• W3201799293 hasConcept C137620995 @default.
• W3201799293 hasConcept C170493617 @default.
• W3201799293 hasConcept C182819311 @default.
• W3201799293 hasConcept C199343813 @default.
• W3201799293 hasConcept C207001950 @default.
• W3201799293 hasConcept C26374806 @default.
• W3201799293 hasConcept C2777109110 @default.
• W3201799293 hasConcept C2779428903 @default.
• W3201799293 hasConcept C2780385504 @default.
• W3201799293 hasConcept C30145163 @default.
• W3201799293 hasConcept C54355233 @default.
• W3201799293 hasConcept C62478195 @default.
• W3201799293 hasConcept C71924100 @default.
• W3201799293 hasConcept C86803240 @default.
• W3201799293 hasConcept C88045685 @default.
• W3201799293 hasConcept C95444343 @default.
• W3201799293 hasConceptScore W3201799293C126322002 @default.
• W3201799293 hasConceptScore W3201799293C137620995 @default.
• W3201799293 hasConceptScore W3201799293C170493617 @default.
• W3201799293 hasConceptScore W3201799293C182819311 @default.
• W3201799293 hasConceptScore W3201799293C199343813 @default.
• W3201799293 hasConceptScore W3201799293C207001950 @default.
• W3201799293 hasConceptScore W3201799293C26374806 @default.
• W3201799293 hasConceptScore W3201799293C2777109110 @default.
• W3201799293 hasConceptScore W3201799293C2779428903 @default.
• W3201799293 hasConceptScore W3201799293C2780385504 @default.
• W3201799293 hasConceptScore W3201799293C30145163 @default.
• W3201799293 hasConceptScore W3201799293C54355233 @default.
• W3201799293 hasConceptScore W3201799293C62478195 @default.
• W3201799293 hasConceptScore W3201799293C71924100 @default.
• W3201799293 hasConceptScore W3201799293C86803240 @default.
• W3201799293 hasConceptScore W3201799293C88045685 @default.
• W3201799293 hasConceptScore W3201799293C95444343 @default.
• W3201799293 hasFunder F4320334764 @default.
• W3201799293 hasIssue "1" @default.
• W3201799293 hasLocation W32017992931 @default.
• W3201799293 hasLocation W32017992932 @default.
• W3201799293 hasLocation W32017992933 @default.
• W3201799293 hasLocation W32017992934 @default.
• W3201799293 hasLocation W32017992935 @default.
• W3201799293 hasOpenAccess W3201799293 @default.
• W3201799293 hasPrimaryLocation W32017992931 @default.

• next