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- W3201814069 abstract "Cluster of differentiation 47 (CD47)/signal regulatory protein alpha (SIRPα) is a negative innate immune checkpoint signaling pathway that restrains immunosurveillance and immune clearance, and thus has aroused wide interest in cancer immunotherapy. Blockade of the CD47/SIRPα signaling pathway shows remarkable antitumor effects in clinical trials. Currently, all inhibitors targeting CD47/SIRPα in clinical trials are biomacromolecules. The poor permeability and undesirable oral bioavailability of biomacromolecules have caused researchers to develop small-molecule CD47/SIRPα pathway inhibitors. This review will summarize the recent advances in CD47/SIRPα interactions, including crystal structures, peptides and small molecule inhibitors. In particular, we have employed computer-aided drug discovery (CADD) approaches to analyze all the published crystal structures and docking results of small molecule inhibitors of CD47/SIRPα, providing insight into the key interaction information to facilitate future development of small molecule CD47/SIRPα inhibitors." @default.
- W3201814069 created "2021-10-11" @default.
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- W3201814069 date "2021-01-01" @default.
- W3201814069 modified "2023-10-18" @default.
- W3201814069 title "Structural analysis and binding sites of inhibitors targeting the CD47/SIRPα interaction in anticancer therapy" @default.
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- W3201814069 cites W1997065981 @default.
- W3201814069 cites W2002220495 @default.
- W3201814069 cites W2018917333 @default.
- W3201814069 cites W2037355822 @default.
- W3201814069 cites W2057796048 @default.
- W3201814069 cites W2063192133 @default.
- W3201814069 cites W2066671159 @default.
- W3201814069 cites W2068052762 @default.
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- W3201814069 cites W2127122881 @default.
- W3201814069 cites W2137187071 @default.
- W3201814069 cites W2141253335 @default.
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- W3201814069 doi "https://doi.org/10.1016/j.csbj.2021.09.036" @default.
- W3201814069 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8517548" @default.
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