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- W3201815152 abstract "In the present study, an eco-friendly, biodegradable, biocompatible, non-immunogenic, non-toxic polysaccharide, carboxymethyl cellulose (CMC), derivatived from renewable biomass cellulose, was used for designing and fabrication a folic acid modified pH and reduction dual-responsive carboxymethyl cellulose-based microcapsules (FA-PRCMCs). The curcumin (CUR)-loaded microcapsules ([email protected]) were prepared via a quick, efficient and environment-friendly sonochemical method, and were employed for the targeted delivery and pH/reduction dual-stimuli-responsive release of CUR. The excess CUR and ethyl acetate phases could be recycled and reused after preparation of [email protected] to avoid wasting resources and polluting the environment. The obtained FA-PRCMCs showed good biocompatibility and targeting in anti-tumor evaluation and endocytosis evaluation in vitro. FA-PRCMCs could effectively reduce the unnecessary damage to normal cells by chemotherapy drugs, and improve the utilization of chemotherapy drugs to reduce therapy costs. FA-PRCMCs could be used as smart targeted delivery vectors and have great clinical application potential." @default.
- W3201815152 created "2021-10-11" @default.
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- W3201815152 date "2022-01-01" @default.
- W3201815152 modified "2023-10-01" @default.
- W3201815152 title "Synthesis and characterization of curcumin-loaded pH/reduction dual-responsive folic acid modified carboxymethyl cellulose-based microcapsules for targeted drug delivery" @default.
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- W3201815152 doi "https://doi.org/10.1016/j.jiec.2021.09.021" @default.
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