Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201819668> ?p ?o ?g. }
- W3201819668 endingPage "766" @default.
- W3201819668 startingPage "755" @default.
- W3201819668 abstract "Bone sarcomas are rare and heterogenous cancers with an incidence of 12/10e6 per year; osteosarcoma, Ewing's sarcomas, chondrosarcomas, chordoma, undifferentiated sarcoma, and giant cell tumor of the bone are the most common and most studied tumors for the development of novel agents and strategies. Contrasting with other sarcomas, few actionable driver mutations on key oncogenes or tumor suppressor genes were identified in bone sarcomas, resulting in a more limited development of targeted treatment in these tumors. Still, antiangiogenic agents are active in most of the primary bone cancers, as demonstrated in a series of randomized and single-arm clinical trials. Immunotherapy with anti-PD-1 Ab has limited activity in unselected histological subtypes with the notable exception of chordoma. Administration of mifamurtide in postoperative setting in localized osteosarcoma demonstrated an improved survival in osteosarcomas. Anti-IGF1R Ab provided prolonged response in a small proportion of patients with advanced bone sarcoma, in particular in Ewing's sarcoma and osteosarcomas. Anti-RANKL therapy was demonstrated highly active in patients with giant cell tumors of the bone not amenable to a curative treatment, with prolonged tumor control over decades. The development of novel therapies in primary bone cancer will depend on a better understanding of the molecular mechanisms of tumor transformation and progression as well as immune cell modulation, and will require international collaboration given the rarity of these tumors." @default.
- W3201819668 created "2021-10-11" @default.
- W3201819668 creator A5004458586 @default.
- W3201819668 creator A5007096008 @default.
- W3201819668 creator A5042202815 @default.
- W3201819668 creator A5047925931 @default.
- W3201819668 creator A5078267188 @default.
- W3201819668 date "2022-01-01" @default.
- W3201819668 modified "2023-09-28" @default.
- W3201819668 title "New therapeutic advances of bone sarcomas" @default.
- W3201819668 cites W1021223646 @default.
- W3201819668 cites W1572906866 @default.
- W3201819668 cites W1607625464 @default.
- W3201819668 cites W1846586690 @default.
- W3201819668 cites W1973726986 @default.
- W3201819668 cites W1986784478 @default.
- W3201819668 cites W1988995169 @default.
- W3201819668 cites W1991236371 @default.
- W3201819668 cites W2004087152 @default.
- W3201819668 cites W2004724104 @default.
- W3201819668 cites W2028541032 @default.
- W3201819668 cites W2031700343 @default.
- W3201819668 cites W2044313879 @default.
- W3201819668 cites W2048765718 @default.
- W3201819668 cites W2056155872 @default.
- W3201819668 cites W2061054148 @default.
- W3201819668 cites W2062845584 @default.
- W3201819668 cites W2065704448 @default.
- W3201819668 cites W2097881410 @default.
- W3201819668 cites W2104411566 @default.
- W3201819668 cites W2110843592 @default.
- W3201819668 cites W2112866395 @default.
- W3201819668 cites W2144717536 @default.
- W3201819668 cites W2149894615 @default.
- W3201819668 cites W2151444534 @default.
- W3201819668 cites W2152274262 @default.
- W3201819668 cites W2159152276 @default.
- W3201819668 cites W2159876545 @default.
- W3201819668 cites W2161009819 @default.
- W3201819668 cites W2170417775 @default.
- W3201819668 cites W2390782195 @default.
- W3201819668 cites W2431282426 @default.
- W3201819668 cites W2460409543 @default.
- W3201819668 cites W2467559786 @default.
- W3201819668 cites W2473766695 @default.
- W3201819668 cites W2482317309 @default.
- W3201819668 cites W2529083835 @default.
- W3201819668 cites W2594071156 @default.
- W3201819668 cites W2603912459 @default.
- W3201819668 cites W2611022823 @default.
- W3201819668 cites W2613199308 @default.
- W3201819668 cites W2634549532 @default.
- W3201819668 cites W2689625606 @default.
- W3201819668 cites W2730021240 @default.
- W3201819668 cites W2738818252 @default.
- W3201819668 cites W2743351613 @default.
- W3201819668 cites W2758151211 @default.
- W3201819668 cites W2762797139 @default.
- W3201819668 cites W2766564047 @default.
- W3201819668 cites W2770975168 @default.
- W3201819668 cites W2784434802 @default.
- W3201819668 cites W2790210280 @default.
- W3201819668 cites W2790254562 @default.
- W3201819668 cites W2800642986 @default.
- W3201819668 cites W2889701300 @default.
- W3201819668 cites W2891557623 @default.
- W3201819668 cites W2894974756 @default.
- W3201819668 cites W2899477358 @default.
- W3201819668 cites W2899939395 @default.
- W3201819668 cites W2901259053 @default.
- W3201819668 cites W2909620693 @default.
- W3201819668 cites W2912062181 @default.
- W3201819668 cites W2914626021 @default.
- W3201819668 cites W2925399593 @default.
- W3201819668 cites W2939228953 @default.
- W3201819668 cites W2941090871 @default.
- W3201819668 cites W2963162257 @default.
- W3201819668 cites W2963532830 @default.
- W3201819668 cites W2968570351 @default.
- W3201819668 cites W2969258830 @default.
- W3201819668 cites W2972784280 @default.
- W3201819668 cites W2978260261 @default.
- W3201819668 cites W2983160271 @default.
- W3201819668 cites W2983489711 @default.
- W3201819668 cites W2996470197 @default.
- W3201819668 cites W2999136960 @default.
- W3201819668 cites W3000282923 @default.
- W3201819668 cites W3000800097 @default.
- W3201819668 cites W3006180429 @default.
- W3201819668 cites W3013902201 @default.
- W3201819668 cites W3021316146 @default.
- W3201819668 cites W3036166213 @default.
- W3201819668 cites W3081520117 @default.
- W3201819668 cites W3082053136 @default.
- W3201819668 cites W3094065587 @default.
- W3201819668 cites W3131890445 @default.
- W3201819668 doi "https://doi.org/10.1016/b978-0-12-821666-8.00072-4" @default.
- W3201819668 hasPublicationYear "2022" @default.