FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201827800> ?p ?o ?g. }

• W3201827800 endingPage "1492" @default.
• W3201827800 startingPage "1483" @default.
• W3201827800 abstract "Secondary gliosarcoma (SGS) rarely arises post treatment of primary glioblastoma multiforme (GBM), and contains gliomatous and sarcomatous components. The origin and clonal evolution of SGS sarcomatous components remain uncharacterized. Therapeutic radiation is mutagenic and can induce sarcomas in patients with other tumor phenotypes, but possible causal relationships between radiotherapy and induction of SGS sarcomatous components remain unexplored. Herein, we investigated the clonal origin of SGS in a patient with primary GBM progressing into SGS post-radiochemotherapy.Somatic mutation profile in GBM and SGS was examined using whole-genome sequencing and deep-whole-exome sequencing. Mutation signatures were characterized to investigate relationships between radiochemotherapy and SGS pathogenesis.A mutation cluster containing two founding mutations in tumor-suppressor genes NF1 (variant allele frequency [VAF]: 50.0% in GBM and 51.1% in SGS) and TP53 (VAF: 26.7% in GBM and 50.8% in SGS) was shared in GBM and SGS. SGS exhibited an overpresented C>A (G>T) transversion (oxidative DNA damage signature) but no signature 11 mutations (alkylating-agents - exposure signature). Since radiation induces DNA lesions by generating reactive oxygen species, the mutations observed in this case of SGS were likely the result of radiotherapy rather than chemotherapy.Secondary gliosarcoma components likely have a monoclonal origin, and the clone possessing mutations in NF1 and TP53 was likely the founding clone in this case of SGS." @default.
• W3201827800 created "2021-10-11" @default.
• W3201827800 creator A5005624803 @default.
• W3201827800 creator A5009012652 @default.
• W3201827800 creator A5029551679 @default.
• W3201827800 creator A5051363890 @default.
• W3201827800 creator A5052391925 @default.
• W3201827800 creator A5058019217 @default.
• W3201827800 creator A5074461919 @default.
• W3201827800 creator A5087211062 @default.
• W3201827800 creator A5091392228 @default.
• W3201827800 date "2021-10-04" @default.
• W3201827800 modified "2023-10-08" @default.
• W3201827800 title "Genetic alteration and clonal evolution of primary glioblastoma into secondary gliosarcoma" @default.
• W3201827800 cites W1601759476 @default.
• W3201827800 cites W169500027 @default.
• W3201827800 cites W1731306022 @default.
• W3201827800 cites W1937206698 @default.
• W3201827800 cites W1963574391 @default.
• W3201827800 cites W1973463126 @default.
• W3201827800 cites W1979395779 @default.
• W3201827800 cites W1982420537 @default.
• W3201827800 cites W1994810553 @default.
• W3201827800 cites W1995371802 @default.
• W3201827800 cites W1999272552 @default.
• W3201827800 cites W2011255294 @default.
• W3201827800 cites W2032059141 @default.
• W3201827800 cites W2056987446 @default.
• W3201827800 cites W2072650390 @default.
• W3201827800 cites W2090862957 @default.
• W3201827800 cites W2103441770 @default.
• W3201827800 cites W2109816625 @default.
• W3201827800 cites W2110110177 @default.
• W3201827800 cites W2113729674 @default.
• W3201827800 cites W2121743948 @default.
• W3201827800 cites W2132188293 @default.
• W3201827800 cites W2146005104 @default.
• W3201827800 cites W2152061559 @default.
• W3201827800 cites W2155870124 @default.
• W3201827800 cites W2366536035 @default.
• W3201827800 cites W2552158984 @default.
• W3201827800 cites W2606616407 @default.
• W3201827800 cites W2626586494 @default.
• W3201827800 cites W2777070305 @default.
• W3201827800 cites W2777126971 @default.
• W3201827800 cites W2808484886 @default.
• W3201827800 cites W2887450365 @default.
• W3201827800 cites W2895863613 @default.
• W3201827800 cites W2896671924 @default.
• W3201827800 cites W2915370829 @default.
• W3201827800 cites W2950882756 @default.
• W3201827800 cites W2995896640 @default.
• W3201827800 cites W2997711727 @default.
• W3201827800 cites W3004981835 @default.
• W3201827800 cites W3016456366 @default.
• W3201827800 cites W3031007427 @default.
• W3201827800 cites W3106961467 @default.
• W3201827800 cites W3201827800 @default.
• W3201827800 cites W4252232449 @default.
• W3201827800 cites W59262689 @default.
• W3201827800 doi "https://doi.org/10.1111/cns.13740" @default.
• W3201827800 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8611784" @default.
• W3201827800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34605602" @default.
• W3201827800 hasPublicationYear "2021" @default.
• W3201827800 type Work @default.
• W3201827800 sameAs 3201827800 @default.
• W3201827800 citedByCount "6" @default.
• W3201827800 countsByYear W32018278002021 @default.
• W3201827800 countsByYear W32018278002022 @default.
• W3201827800 countsByYear W32018278002023 @default.
• W3201827800 crossrefType "journal-article" @default.
• W3201827800 hasAuthorship W3201827800A5005624803 @default.
• W3201827800 hasAuthorship W3201827800A5009012652 @default.
• W3201827800 hasAuthorship W3201827800A5029551679 @default.
• W3201827800 hasAuthorship W3201827800A5051363890 @default.
• W3201827800 hasAuthorship W3201827800A5052391925 @default.
• W3201827800 hasAuthorship W3201827800A5058019217 @default.
• W3201827800 hasAuthorship W3201827800A5074461919 @default.
• W3201827800 hasAuthorship W3201827800A5087211062 @default.
• W3201827800 hasAuthorship W3201827800A5091392228 @default.
• W3201827800 hasBestOaLocation W32018278001 @default.
• W3201827800 hasConcept C104317684 @default.
• W3201827800 hasConcept C13514818 @default.
• W3201827800 hasConcept C16671776 @default.
• W3201827800 hasConcept C2777295375 @default.
• W3201827800 hasConcept C2778227246 @default.
• W3201827800 hasConcept C501734568 @default.
• W3201827800 hasConcept C502942594 @default.
• W3201827800 hasConcept C54355233 @default.
• W3201827800 hasConcept C81089528 @default.
• W3201827800 hasConcept C86803240 @default.
• W3201827800 hasConceptScore W3201827800C104317684 @default.
• W3201827800 hasConceptScore W3201827800C13514818 @default.
• W3201827800 hasConceptScore W3201827800C16671776 @default.
• W3201827800 hasConceptScore W3201827800C2777295375 @default.
• W3201827800 hasConceptScore W3201827800C2778227246 @default.
• W3201827800 hasConceptScore W3201827800C501734568 @default.
• W3201827800 hasConceptScore W3201827800C502942594 @default.

• next