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- W3201843140 endingPage "5011" @default.
- W3201843140 startingPage "5011" @default.
- W3201843140 abstract "Ovarian cancer is a heterogeneous disease affecting the aging ovary, in concert with a complex network of cells and signals, together representing the ovarian tumor microenvironment. As in the Schrödinger's cat thought experiment, the context-dependent constituents of the-by the time of diagnosis-well-established tumor microenvironment may display a tumor-protective and -destructive role. Systemic and locally synthesized estrogens contribute to the formation of a pro-tumoral microenvironment that enables the sustained tumor growth, invasion and metastasis. Here we focus on the estrogen biosynthetic and metabolic pathways in ovarian cancer and elaborate their actions on phenotypically plastic, estrogen-responsive, aging immune cells of the tumor microenvironment, altogether highlighting the multicomponent-connectedness and complexity of cancer, and contributing to a broader understanding of the ovarian cancer biology." @default.
- W3201843140 created "2021-10-11" @default.
- W3201843140 creator A5040998934 @default.
- W3201843140 creator A5069384513 @default.
- W3201843140 date "2021-10-06" @default.
- W3201843140 modified "2023-10-16" @default.
- W3201843140 title "Estrogens and the Schrödinger’s Cat in the Ovarian Tumor Microenvironment" @default.
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