Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201847124> ?p ?o ?g. }
- W3201847124 abstract "Interplay between the second messengers cAMP and Ca2+ is a hallmark of dynamic cellular processes. A common motif is the opposition of the Ca2+-sensitive phosphatase calcineurin and the major cAMP receptor, protein kinase A (PKA). Calcineurin dephosphorylates sites primed by PKA to bring about changes including synaptic long-term depression (LTD). AKAP79 supports signaling of this type by anchoring PKA and calcineurin in tandem. In this study, we discovered that AKAP79 increases the rate of calcineurin dephosphorylation of type II PKA regulatory subunits by an order of magnitude. Fluorescent PKA activity reporter assays, supported by kinetic modeling, show how AKAP79-enhanced calcineurin activity enables suppression of PKA without altering cAMP levels by increasing PKA catalytic subunit capture rate. Experiments with hippocampal neurons indicate that this mechanism contributes toward LTD. This non-canonical mode of PKA regulation may underlie many other cellular processes." @default.
- W3201847124 created "2021-10-11" @default.
- W3201847124 creator A5016743656 @default.
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- W3201847124 creator A5066250270 @default.
- W3201847124 creator A5084813027 @default.
- W3201847124 date "2021-10-06" @default.
- W3201847124 modified "2023-10-07" @default.
- W3201847124 title "AKAP79 enables calcineurin to directly suppress protein kinase A activity" @default.
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- W3201847124 doi "https://doi.org/10.7554/elife.68164" @default.
- W3201847124 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8560092" @default.
- W3201847124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34612814" @default.
- W3201847124 hasPublicationYear "2021" @default.