FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201860900> ?p ?o ?g. }

• W3201860900 endingPage "1158" @default.
• W3201860900 startingPage "1149" @default.
• W3201860900 abstract "Breakpoint cluster region-Abelson (BCR-ABL) negative myeloproliferative neoplasms (MPNs) are chronic myeloid neoplasms initiated by the acquisition of gene mutation(s) in a haematopoietic stem cell, leading to clonal expansion and over-production of blood cells and their progenitors. MPNs encompass a spectrum of disorders with overlapping but distinct molecular, laboratory and clinical features. This includes polycythaemia vera, essential thrombocythaemia and myelofibrosis. Dysregulation of the immune system is key to the pathology of MPNs, supporting clonal evolution, mediating symptoms and resulting in varying degrees of immunocompromise. Targeting immune dysfunction is an important treatment strategy. In the present review, we focus on the immune landscape in patients with MPNs - the role of inflammation in disease pathogenesis, susceptibility to infection and emerging strategies for therapeutic immune modulation. Further detailed work is required to delineate immune perturbation more precisely in MPNs to determine how and why vulnerability to infection differs between clinical subtypes and to better understand how inflammation results in a competitive advantage for the MPN clone. These studies may help shed light on new designs for disease-modifying therapies." @default.
• W3201860900 created "2021-10-11" @default.
• W3201860900 creator A5022379053 @default.
• W3201860900 creator A5035853507 @default.
• W3201860900 creator A5053302921 @default.
• W3201860900 date "2021-10-07" @default.
• W3201860900 modified "2023-09-25" @default.
• W3201860900 title "The immune landscape in BCR‐ABL negative myeloproliferative neoplasms: inflammation, infections and opportunities for immunotherapy" @default.
• W3201860900 cites W1148460347 @default.
• W3201860900 cites W1910012553 @default.
• W3201860900 cites W1923214677 @default.
• W3201860900 cites W1968931030 @default.
• W3201860900 cites W1994993231 @default.
• W3201860900 cites W1997605010 @default.
• W3201860900 cites W2005661051 @default.
• W3201860900 cites W2009954157 @default.
• W3201860900 cites W2010507912 @default.
• W3201860900 cites W2012249056 @default.
• W3201860900 cites W2017903152 @default.
• W3201860900 cites W2020294706 @default.
• W3201860900 cites W2028334401 @default.
• W3201860900 cites W2028815852 @default.
• W3201860900 cites W2031251938 @default.
• W3201860900 cites W2040664937 @default.
• W3201860900 cites W2041591102 @default.
• W3201860900 cites W2058380732 @default.
• W3201860900 cites W2078678444 @default.
• W3201860900 cites W2079681891 @default.
• W3201860900 cites W2089881927 @default.
• W3201860900 cites W2097694060 @default.
• W3201860900 cites W2100303019 @default.
• W3201860900 cites W2111141291 @default.
• W3201860900 cites W2119896120 @default.
• W3201860900 cites W2121743767 @default.
• W3201860900 cites W2122395736 @default.
• W3201860900 cites W2122567448 @default.
• W3201860900 cites W2123441931 @default.
• W3201860900 cites W2123633897 @default.
• W3201860900 cites W2128719261 @default.
• W3201860900 cites W2129148152 @default.
• W3201860900 cites W2130869560 @default.
• W3201860900 cites W2132824554 @default.
• W3201860900 cites W2134290384 @default.
• W3201860900 cites W2142541925 @default.
• W3201860900 cites W2143668961 @default.
• W3201860900 cites W2149449736 @default.
• W3201860900 cites W2167405925 @default.
• W3201860900 cites W2177738737 @default.
• W3201860900 cites W2205886515 @default.
• W3201860900 cites W2212356361 @default.
• W3201860900 cites W2234747672 @default.
• W3201860900 cites W2284541528 @default.
• W3201860900 cites W2509761752 @default.
• W3201860900 cites W2524990707 @default.
• W3201860900 cites W2532748735 @default.
• W3201860900 cites W2534149640 @default.
• W3201860900 cites W2543049646 @default.
• W3201860900 cites W2560536699 @default.
• W3201860900 cites W2614253029 @default.
• W3201860900 cites W2724288088 @default.
• W3201860900 cites W2749657249 @default.
• W3201860900 cites W2751967109 @default.
• W3201860900 cites W2769707416 @default.
• W3201860900 cites W2773899764 @default.
• W3201860900 cites W2788391979 @default.
• W3201860900 cites W2790040007 @default.
• W3201860900 cites W2901656544 @default.
• W3201860900 cites W2944293062 @default.
• W3201860900 cites W2954062012 @default.
• W3201860900 cites W2954384525 @default.
• W3201860900 cites W2966131538 @default.
• W3201860900 cites W2981101665 @default.
• W3201860900 cites W2986616996 @default.
• W3201860900 cites W2988252576 @default.
• W3201860900 cites W2988420853 @default.
• W3201860900 cites W2990179403 @default.
• W3201860900 cites W3012573821 @default.
• W3201860900 cites W3019820338 @default.
• W3201860900 cites W3022009389 @default.
• W3201860900 cites W3022543485 @default.
• W3201860900 cites W3023675772 @default.
• W3201860900 cites W3029926323 @default.
• W3201860900 cites W3030185188 @default.
• W3201860900 cites W3035498579 @default.
• W3201860900 cites W3036443347 @default.
• W3201860900 cites W3038273023 @default.
• W3201860900 cites W3040003446 @default.
• W3201860900 cites W3041411480 @default.
• W3201860900 cites W3049244854 @default.
• W3201860900 cites W3080162924 @default.
• W3201860900 cites W3081522004 @default.
• W3201860900 cites W3082575175 @default.
• W3201860900 cites W3094802395 @default.
• W3201860900 cites W3095588081 @default.
• W3201860900 cites W3097738396 @default.
• W3201860900 cites W3101874399 @default.
• W3201860900 cites W3110102301 @default.
• W3201860900 cites W3112861455 @default.

• next