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- W3201874977 abstract "Abstract Purpose: Study the potential mechanism of methionine restriction (MR) inhibiting colon cancer (CC). Materials and Methods: The differential expression genes (DEGs) of the CC cell line HCT116 after MR restriction treatment in the GSE72131 and GSE103602 data sets were identified, and functional enrichment analysis was performed. Furthermore, the DEGs of CC in the TCGA database were identified, and the MR-related DEGs were combined to establish transcriptional regulation (TR), competing endogenous RNA (ceRNA), and protein-protein interaction (PPI) networks, and identify key genes from it. Then, in vitro experiments were performed to analyze the effects of MR on the proliferation, invasion, migration, and apoptosis of HCT116 cells, and to verify the effects of MR on the expression of key genes identified. Results: In HCT116 cells, 1181 genes regulated by MR were identified, and their functional enrichment suggests that they are closely related to tumor progression. Combined with the DEGs of CC, a total of 330 dysregulated genes of CC were affected by MR. 6 hub genes (E2F1, MIR17HG, FANCI, HJURP, KPNA2, KIF15) were obtained from the TR, ceRNA, and PPI network constructed based on this, and the results were consistent with the analysis by rt-PCR. In vitro studies have shown that MR can inhibit the proliferation and metastasis of CC cells and promote apoptosis. Conclusion: MR may inhibit the progress of CC by down-regulating the expression of E2F1, MIR17HG, FANCI, HJURP, KPNA2, and KIF15." @default.
- W3201874977 created "2021-10-11" @default.
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- W3201874977 date "2021-09-30" @default.
- W3201874977 modified "2023-09-27" @default.
- W3201874977 title "To Identify and Verify the Role and Crucial Genes of Methionine Restriction in Inhibiting the Progression of Colon Cancer Cells" @default.
- W3201874977 doi "https://doi.org/10.21203/rs.3.rs-923908/v1" @default.
- W3201874977 hasPublicationYear "2021" @default.
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