Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201877532> ?p ?o ?g. }
- W3201877532 endingPage "2807.e8" @default.
- W3201877532 startingPage "2790" @default.
- W3201877532 abstract "SARS-CoV-2 virions are surrounded by a lipid bilayer that contains membrane proteins such as spike, responsible for target-cell binding and virus fusion. We found that during SARS-CoV-2 infection, spike becomes lipid modified, through the sequential action of the S-acyltransferases ZDHHC20 and 9. Particularly striking is the rapid acylation of spike on 10 cytosolic cysteines within the ER and Golgi. Using a combination of computational, lipidomics, and biochemical approaches, we show that this massive lipidation controls spike biogenesis and degradation, and drives the formation of localized ordered cholesterol and sphingolipid-rich lipid nanodomains in the early Golgi, where viral budding occurs. Finally, S-acylation of spike allows the formation of viruses with enhanced fusion capacity. Our study points toward S-acylating enzymes and lipid biosynthesis enzymes as novel therapeutic anti-viral targets." @default.
- W3201877532 created "2021-10-11" @default.
- W3201877532 creator A5016180753 @default.
- W3201877532 creator A5027273147 @default.
- W3201877532 creator A5028482162 @default.
- W3201877532 creator A5030673471 @default.
- W3201877532 creator A5044086190 @default.
- W3201877532 creator A5044522681 @default.
- W3201877532 creator A5061089601 @default.
- W3201877532 creator A5065598178 @default.
- W3201877532 creator A5068821735 @default.
- W3201877532 creator A5071923604 @default.
- W3201877532 creator A5073688967 @default.
- W3201877532 creator A5076325070 @default.
- W3201877532 creator A5082365845 @default.
- W3201877532 creator A5082873965 @default.
- W3201877532 date "2021-10-01" @default.
- W3201877532 modified "2023-10-17" @default.
- W3201877532 title "S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity" @default.
- W3201877532 cites W1031578623 @default.
- W3201877532 cites W1491507080 @default.
- W3201877532 cites W1505815416 @default.
- W3201877532 cites W1800763284 @default.
- W3201877532 cites W1964667115 @default.
- W3201877532 cites W1971894038 @default.
- W3201877532 cites W1996977823 @default.
- W3201877532 cites W2000987281 @default.
- W3201877532 cites W2007199806 @default.
- W3201877532 cites W2021520922 @default.
- W3201877532 cites W2025200316 @default.
- W3201877532 cites W2029667189 @default.
- W3201877532 cites W2037824992 @default.
- W3201877532 cites W2040462912 @default.
- W3201877532 cites W2049286183 @default.
- W3201877532 cites W2067797438 @default.
- W3201877532 cites W2072485950 @default.
- W3201877532 cites W2093392569 @default.
- W3201877532 cites W2095988962 @default.
- W3201877532 cites W2104174436 @default.
- W3201877532 cites W2107063920 @default.
- W3201877532 cites W2107198142 @default.
- W3201877532 cites W2111841727 @default.
- W3201877532 cites W2119109208 @default.
- W3201877532 cites W2119267663 @default.
- W3201877532 cites W2125872855 @default.
- W3201877532 cites W2128679305 @default.
- W3201877532 cites W2129932192 @default.
- W3201877532 cites W2134450080 @default.
- W3201877532 cites W2140388343 @default.
- W3201877532 cites W2146850348 @default.
- W3201877532 cites W2164775580 @default.
- W3201877532 cites W2168341495 @default.
- W3201877532 cites W2170193142 @default.
- W3201877532 cites W2429365795 @default.
- W3201877532 cites W2460255279 @default.
- W3201877532 cites W2743526077 @default.
- W3201877532 cites W2766014895 @default.
- W3201877532 cites W2770539879 @default.
- W3201877532 cites W2783458468 @default.
- W3201877532 cites W2784232630 @default.
- W3201877532 cites W2807549207 @default.
- W3201877532 cites W2883572783 @default.
- W3201877532 cites W2947828382 @default.
- W3201877532 cites W2952120501 @default.
- W3201877532 cites W2952383690 @default.
- W3201877532 cites W2965689579 @default.
- W3201877532 cites W2977355839 @default.
- W3201877532 cites W2993780472 @default.
- W3201877532 cites W2998139905 @default.
- W3201877532 cites W3001465255 @default.
- W3201877532 cites W3005622563 @default.
- W3201877532 cites W3005811007 @default.
- W3201877532 cites W3006868374 @default.
- W3201877532 cites W3008394341 @default.
- W3201877532 cites W3009912996 @default.
- W3201877532 cites W3013186573 @default.
- W3201877532 cites W3017302293 @default.
- W3201877532 cites W3022285953 @default.
- W3201877532 cites W3023376619 @default.
- W3201877532 cites W3026002191 @default.
- W3201877532 cites W3036635817 @default.
- W3201877532 cites W3039901154 @default.
- W3201877532 cites W3046881056 @default.
- W3201877532 cites W3049142173 @default.
- W3201877532 cites W3083130172 @default.
- W3201877532 cites W3096967708 @default.
- W3201877532 cites W3103021984 @default.
- W3201877532 cites W3106737244 @default.
- W3201877532 cites W3112772443 @default.
- W3201877532 cites W3142432096 @default.
- W3201877532 cites W3156389344 @default.
- W3201877532 cites W3166621072 @default.
- W3201877532 cites W3182225123 @default.
- W3201877532 cites W3187724905 @default.
- W3201877532 doi "https://doi.org/10.1016/j.devcel.2021.09.016" @default.
- W3201877532 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8486083" @default.
- W3201877532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34599882" @default.
- W3201877532 hasPublicationYear "2021" @default.