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- W3201877549 endingPage "142" @default.
- W3201877549 startingPage "131" @default.
- W3201877549 abstract "Chronic respiratory diseases (CRDs), including pulmonary fibrosis, chronic obstructive pulmonary disease (COPD), lung cancer, and asthma, are significant global health problems due to their prevalence and rising incidence. The roles of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs) in controlling tyrosine phosphorylation of targeting proteins modulate multiple physiological cellular responses and contribute to the pathogenesis of CRDs. Src homology-2 domain-containing PTP2 (SHP2) plays a pivotal role in modulating downstream growth factor receptor signaling and cytoplasmic PTKs, including MAPK/ERK, PI3K/AKT, and JAK/STAT pathways, to regulate cell survival and proliferation. In addition, SHP2 mutation and activation are commonly implicated in tumorigenesis. However, little is known about SHP2 in chronic pulmonary inflammation and fibrosis. This review discusses the potential involvement of SHP2 deregulation in chronic pulmonary inflammation and fibrosis, as well as the therapeutic effects of targeting SHP2 in CRDs." @default.
- W3201877549 created "2021-10-11" @default.
- W3201877549 creator A5016332090 @default.
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- W3201877549 creator A5062115647 @default.
- W3201877549 creator A5068448490 @default.
- W3201877549 creator A5078067660 @default.
- W3201877549 date "2021-09-30" @default.
- W3201877549 modified "2023-10-17" @default.
- W3201877549 title "<scp>SHP2</scp>: The protein tyrosine phosphatase involved in chronic pulmonary inflammation and fibrosis" @default.
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- W3201877549 doi "https://doi.org/10.1002/iub.2559" @default.
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- W3201877549 hasPublicationYear "2021" @default.
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