FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201896200> ?p ?o ?g. }

• W3201896200 endingPage "292" @default.
• W3201896200 startingPage "281" @default.
• W3201896200 abstract "Several nonmalignant disorders (NMDs), either inherited or acquired, can be cured by allogeneic hematopoietic stem cell transplantation (HSCT). Between January 2012 and April 2020, 70 consecutive children affected by primary immunodeficiencies, inherited/acquired bone marrow failure syndromes, red blood cell disorders, or metabolic diseases, lacking a fully matched donor or requiring urgent transplantation underwent TCRαβ/CD19-depleted haploidentical HSCT from an HLA-partially matched relative as part of a prospective study. The median age at transplant was 3.5 years (range 0.3-16.1); the median time from diagnosis to transplant was 10.5 months (2.7 for SCID patients). Primary engraftment was obtained in 51 patients, while 19 and 2 patients experienced either primary or secondary graft failure (GF), the overall incidence of this complication being 30.4%. Most GFs were observed in children with disease at risk for this complication (eg, aplastic anemia, thalassemia). All but 5 patients experiencing GF were successfully retransplanted. Six patients died of infectious complications (4 had active/recent infections at the time of HSCT), the cumulative incidence of transplant-related mortality (TRM) being 8.5%. Cumulative incidence of grade 1-2 acute GVHD was 14.4% (no patient developed grade 3-4 acute GVHD). Only one patient at risk developed mild chronic GVHD. With a median follow-up of 3.5 years, the 5-year probability of overall and disease-free survival was 91.4% and 86.8%, respectively. In conclusion, TCRαβ/CD19-depleted haploidentical HSCT from an HLA-partially matched relative is confirmed to be an effective treatment of children with NMDs. Prompt donor availability, low incidence of GVHD, and TRM make this strategy an attractive option in NMDs patients. The study is registered at ClinicalTrial.gov as NCT01810120." @default.
• W3201896200 created "2021-10-11" @default.
• W3201896200 creator A5005006393 @default.
• W3201896200 creator A5005455171 @default.
• W3201896200 creator A5017556252 @default.
• W3201896200 creator A5022712318 @default.
• W3201896200 creator A5034444123 @default.
• W3201896200 creator A5035849763 @default.
• W3201896200 creator A5045397485 @default.
• W3201896200 creator A5047066070 @default.
• W3201896200 creator A5047993250 @default.
• W3201896200 creator A5050873961 @default.
• W3201896200 creator A5053932257 @default.
• W3201896200 creator A5059228602 @default.
• W3201896200 creator A5065760036 @default.
• W3201896200 creator A5077335202 @default.
• W3201896200 creator A5081745542 @default.
• W3201896200 creator A5082368982 @default.
• W3201896200 creator A5085927346 @default.
• W3201896200 creator A5088215988 @default.
• W3201896200 creator A5090824736 @default.
• W3201896200 date "2022-01-11" @default.
• W3201896200 modified "2023-09-29" @default.
• W3201896200 title "TCRαβ/CD19 depleted HSCT from an HLA-haploidentical relative to treat children with different nonmalignant disorders" @default.
• W3201896200 cites W1818576030 @default.
• W3201896200 cites W1973604732 @default.
• W3201896200 cites W1978164777 @default.
• W3201896200 cites W1978753064 @default.
• W3201896200 cites W2019111335 @default.
• W3201896200 cites W2042461723 @default.
• W3201896200 cites W2053278212 @default.
• W3201896200 cites W2064575538 @default.
• W3201896200 cites W2086024031 @default.
• W3201896200 cites W2100304556 @default.
• W3201896200 cites W2121960517 @default.
• W3201896200 cites W2142159826 @default.
• W3201896200 cites W2149258821 @default.
• W3201896200 cites W2202574821 @default.
• W3201896200 cites W2215708976 @default.
• W3201896200 cites W2332175111 @default.
• W3201896200 cites W2338464823 @default.
• W3201896200 cites W2379365975 @default.
• W3201896200 cites W2416050694 @default.
• W3201896200 cites W2477294526 @default.
• W3201896200 cites W2530375062 @default.
• W3201896200 cites W2591717879 @default.
• W3201896200 cites W2606493012 @default.
• W3201896200 cites W2621546725 @default.
• W3201896200 cites W2743113491 @default.
• W3201896200 cites W2762629706 @default.
• W3201896200 cites W2767563350 @default.
• W3201896200 cites W2787230005 @default.
• W3201896200 cites W2802087233 @default.
• W3201896200 cites W2885371782 @default.
• W3201896200 cites W2912749691 @default.
• W3201896200 cites W2915461110 @default.
• W3201896200 cites W2917317164 @default.
• W3201896200 cites W2917606322 @default.
• W3201896200 cites W2921075494 @default.
• W3201896200 cites W2937292311 @default.
• W3201896200 cites W2943352303 @default.
• W3201896200 cites W2948596730 @default.
• W3201896200 cites W2971604103 @default.
• W3201896200 cites W2972171376 @default.
• W3201896200 cites W2975502554 @default.
• W3201896200 cites W2979892428 @default.
• W3201896200 cites W2995474568 @default.
• W3201896200 cites W3000301584 @default.
• W3201896200 cites W3005910409 @default.
• W3201896200 cites W3010357077 @default.
• W3201896200 cites W3021363743 @default.
• W3201896200 cites W3024374829 @default.
• W3201896200 cites W3040732116 @default.
• W3201896200 cites W3081019817 @default.
• W3201896200 cites W3087122383 @default.
• W3201896200 cites W3107079130 @default.
• W3201896200 cites W3112124839 @default.
• W3201896200 cites W3112179900 @default.
• W3201896200 cites W3117994633 @default.
• W3201896200 cites W3122836602 @default.
• W3201896200 cites W3129060228 @default.
• W3201896200 cites W3130357443 @default.
• W3201896200 cites W3132897532 @default.
• W3201896200 cites W3135024738 @default.
• W3201896200 cites W4238223649 @default.
• W3201896200 doi "https://doi.org/10.1182/bloodadvances.2021005628" @default.
• W3201896200 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34592755" @default.
• W3201896200 hasPublicationYear "2022" @default.
• W3201896200 type Work @default.
• W3201896200 sameAs 3201896200 @default.
• W3201896200 citedByCount "17" @default.
• W3201896200 countsByYear W32018962002022 @default.
• W3201896200 countsByYear W32018962002023 @default.
• W3201896200 crossrefType "journal-article" @default.
• W3201896200 hasAuthorship W3201896200A5005006393 @default.
• W3201896200 hasAuthorship W3201896200A5005455171 @default.
• W3201896200 hasAuthorship W3201896200A5017556252 @default.
• W3201896200 hasAuthorship W3201896200A5022712318 @default.

• next