Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201925685> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W3201925685 abstract "Background: Autologous platelet-rich fibrin (A-PRF) is an adjunctive method for diabetic foot ulcer (DFU) in addition to glycaemic control and debridement. This study aimed to evaluate the role of A-PRF + hyaluronic acid (HA), A-PRF and sodium chloride 0.9% (control) in DFU wound healing. Nowaday, the use of PRF autologous consider as adjuvant therapy in DFU treatment. Methods: This open-label randomized controlled trial was conducted at Koja District Hospital and Gatot Soebroto Hospital from July 2019 to April 2020. DFU patients with wound duration of three months, Wagner-2, and ulcer size < 40 cm2 were recruited and randomly assigned into A-PRF + AH, A-PRF and control group. On day-0, day-3 and day -7, samples and photographs were taken. Samples were analysed with ELISA and photographs were analysed with ImageJ to calculate granulation index (GI). Statistical analysis was performed using SPSS version 20. Results: Topical therapy with A-PRF + AH was associated with a significant increase in VEGF from day 0 (232.8 pg/mg) vs day 7 (544.5 pg/mg) compared to A-PRF on day 0 (185.7 pg/mg) vs day 7 (272.8 pg/mg), and the controls on day 0 (183.7 pg/mg) vs day 7 (167.4 pg/mg). On evaluation of VEGF swab, there is increasing significantly in A-PRF+HA group compare others group in day -3 ( p=0.022) and day -7 (p= 0.001).In the A-PRF + AH group, there was a significant decrease in IL-6 from day 0 (106.4 pg/mg) vs day 7 (88.7 pg/mg) compared with PRF on day 0 (91.9 pg/mg) vs day 7 (48,8 pg/mg). IL-6 was increased in the control group from day 0 (125.3 pg/mg) vs day 7 (167.9 pg/mg). On evaluation of IL-6 swab, there is decreasing significantly in A-PRF+HA group compare others group in day -7 (p= 0.041). Conclusion: The PRF + HA combination increased angiogenesis and reduced inflammation in DFUs and may represent a new DFU therapy." @default.
- W3201925685 created "2021-10-11" @default.
- W3201925685 creator A5000711510 @default.
- W3201925685 creator A5015855408 @default.
- W3201925685 creator A5031995061 @default.
- W3201925685 creator A5035257274 @default.
- W3201925685 creator A5043569829 @default.
- W3201925685 creator A5045979562 @default.
- W3201925685 creator A5066278015 @default.
- W3201925685 creator A5076359959 @default.
- W3201925685 creator A5078387243 @default.
- W3201925685 creator A5086060242 @default.
- W3201925685 creator A5087923863 @default.
- W3201925685 date "2021-07-01" @default.
- W3201925685 modified "2023-10-01" @default.
- W3201925685 title "Wound Healing in Diabetic Foot Ulcer Patients Using Combined Use of Platelet Rich Fibrin and Hyaluronic Acid, Platelet Rich Fibrin and Placebo: An Open Label, Randomized Controlled Trial" @default.
- W3201925685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34611065" @default.
- W3201925685 hasPublicationYear "2021" @default.
- W3201925685 type Work @default.
- W3201925685 sameAs 3201925685 @default.
- W3201925685 citedByCount "3" @default.
- W3201925685 countsByYear W32019256852022 @default.
- W3201925685 countsByYear W32019256852023 @default.
- W3201925685 crossrefType "journal-article" @default.
- W3201925685 hasAuthorship W3201925685A5000711510 @default.
- W3201925685 hasAuthorship W3201925685A5015855408 @default.
- W3201925685 hasAuthorship W3201925685A5031995061 @default.
- W3201925685 hasAuthorship W3201925685A5035257274 @default.
- W3201925685 hasAuthorship W3201925685A5043569829 @default.
- W3201925685 hasAuthorship W3201925685A5045979562 @default.
- W3201925685 hasAuthorship W3201925685A5066278015 @default.
- W3201925685 hasAuthorship W3201925685A5076359959 @default.
- W3201925685 hasAuthorship W3201925685A5078387243 @default.
- W3201925685 hasAuthorship W3201925685A5086060242 @default.
- W3201925685 hasAuthorship W3201925685A5087923863 @default.
- W3201925685 hasConcept C105702510 @default.
- W3201925685 hasConcept C126322002 @default.
- W3201925685 hasConcept C134018914 @default.
- W3201925685 hasConcept C141071460 @default.
- W3201925685 hasConcept C142724271 @default.
- W3201925685 hasConcept C168563851 @default.
- W3201925685 hasConcept C203014093 @default.
- W3201925685 hasConcept C204787440 @default.
- W3201925685 hasConcept C27081682 @default.
- W3201925685 hasConcept C2777529286 @default.
- W3201925685 hasConcept C2777560349 @default.
- W3201925685 hasConcept C2777858829 @default.
- W3201925685 hasConcept C2778144972 @default.
- W3201925685 hasConcept C2780076745 @default.
- W3201925685 hasConcept C2780269544 @default.
- W3201925685 hasConcept C54173615 @default.
- W3201925685 hasConcept C555293320 @default.
- W3201925685 hasConcept C71924100 @default.
- W3201925685 hasConcept C89560881 @default.
- W3201925685 hasConceptScore W3201925685C105702510 @default.
- W3201925685 hasConceptScore W3201925685C126322002 @default.
- W3201925685 hasConceptScore W3201925685C134018914 @default.
- W3201925685 hasConceptScore W3201925685C141071460 @default.
- W3201925685 hasConceptScore W3201925685C142724271 @default.
- W3201925685 hasConceptScore W3201925685C168563851 @default.
- W3201925685 hasConceptScore W3201925685C203014093 @default.
- W3201925685 hasConceptScore W3201925685C204787440 @default.
- W3201925685 hasConceptScore W3201925685C27081682 @default.
- W3201925685 hasConceptScore W3201925685C2777529286 @default.
- W3201925685 hasConceptScore W3201925685C2777560349 @default.
- W3201925685 hasConceptScore W3201925685C2777858829 @default.
- W3201925685 hasConceptScore W3201925685C2778144972 @default.
- W3201925685 hasConceptScore W3201925685C2780076745 @default.
- W3201925685 hasConceptScore W3201925685C2780269544 @default.
- W3201925685 hasConceptScore W3201925685C54173615 @default.
- W3201925685 hasConceptScore W3201925685C555293320 @default.
- W3201925685 hasConceptScore W3201925685C71924100 @default.
- W3201925685 hasConceptScore W3201925685C89560881 @default.
- W3201925685 hasLocation W32019256851 @default.
- W3201925685 hasOpenAccess W3201925685 @default.
- W3201925685 hasPrimaryLocation W32019256851 @default.
- W3201925685 hasRelatedWork W2809943964 @default.
- W3201925685 hasRelatedWork W3103087827 @default.
- W3201925685 hasRelatedWork W3175541098 @default.
- W3201925685 hasRelatedWork W3189816802 @default.
- W3201925685 hasRelatedWork W3198675387 @default.
- W3201925685 hasRelatedWork W3201925685 @default.
- W3201925685 hasRelatedWork W3213191229 @default.
- W3201925685 hasRelatedWork W4213299276 @default.
- W3201925685 hasRelatedWork W4231679784 @default.
- W3201925685 hasRelatedWork W4287104806 @default.
- W3201925685 isParatext "false" @default.
- W3201925685 isRetracted "false" @default.
- W3201925685 magId "3201925685" @default.
- W3201925685 workType "article" @default.