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- W3201934241 abstract "Bisphenol A (BPA) is a widespread endocrine disruptor affecting many organs and systems. Previous work in our laboratory demonstrated that BPA could induce death due to necroptosis in murine aortic endothelial cells (MAECs). This work aims to evaluate the possible involvement of BPA-induced senescence mechanisms in endothelial cells. The β-Gal assays showed interesting differences in cell senescence at relatively low doses (100 nM and 5 µM). Western blots confirmed that proteins involved in senescence mechanisms, p16 and p21, were overexpressed in the presence of BPA. In addition, the UPR (unfolding protein response) system, which is part of the senescent phenotype, was also explored by Western blot and qPCR, confirming the involvement of the PERK-ATF4-CHOP pathway (related to pathological processes). The endothelium of mice treated with BPA showed an evident increase in the expression of the proteins p16, p21, and CHOP, confirming the results observed in cells. Our results demonstrate that oxidative stress induced by BPA leads to UPR activation and senescence since pretreatment with N-acetylcysteine (NAC) in BPA-treated cells reduced the percentage of senescent cells prevented the overexpression of proteins related to BPA-induced senescence and reduced the activation of the UPR system. The results suggest that BPA participates actively in accelerated cell aging mechanisms, affecting the vascular endothelium and promoting cardiovascular diseases." @default.
- W3201934241 created "2021-10-11" @default.
- W3201934241 creator A5007540951 @default.
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- W3201934241 creator A5087545495 @default.
- W3201934241 date "2021-09-29" @default.
- W3201934241 modified "2023-10-03" @default.
- W3201934241 title "Bisphenol A Induces Accelerated Cell Aging in Murine Endothelium" @default.
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- W3201934241 doi "https://doi.org/10.3390/biom11101429" @default.
- W3201934241 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8533150" @default.
- W3201934241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34680063" @default.
- W3201934241 hasPublicationYear "2021" @default.
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