Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201934781> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W3201934781 abstract "Dabrafenib is a kinase inhibitor used in the treatment of patients with unresectable or metastatic melanoma with specific BRAF variants. Dabrafenib can be used as a single agent to treat melanoma with the BRAF V600E variant, or in combination with the MEK inhibitor trametinib to treat melanoma with BRAF V600E or V600K variants.BRAF is an intracellular kinase in the mitogen-activated protein kinases (MAPK) pathway. BRAF is involved in regulating important cell functions such as cell growth, division, differentiation, and apoptosis. BRAF is also a proto-oncogene—when mutated it has the ability to transform normal cells into cancerous cells.Variation in the kinase domain of BRAF have been associated with various cancers. The most common BRAF variant, V600E, constitutively activates the kinase, and causes cell proliferation in the absence of growth factors that would normally be required. The V600E variant is detected in approximately 50% of melanomas (1, 2).The FDA-approved label for dabrafenib states that the presence of BRAF mutation in tumor specimens (V600E for dabrafenib monotherapy; V600E or V600K for dabrafenib plus trametinib) should be confirmed, using an FDA-approved test, before starting treatment with dabrafenib. Dabrafenib is not indicated for treatment of patients with wild-type BRAF melanoma.The label also states that patients who have glucose-6-phosphate dehydrogenase (G6PD) deficiency should be monitored for signs of hemolytic anemia while taking dabrafenib (3)." @default.
- W3201934781 created "2021-10-11" @default.
- W3201934781 creator A5049365649 @default.
- W3201934781 date "2017-08-15" @default.
- W3201934781 modified "2023-09-25" @default.
- W3201934781 title "Dabrafenib Therapy and BRAF and G6PD Genotype" @default.
- W3201934781 cites W135126065 @default.
- W3201934781 cites W1979181133 @default.
- W3201934781 cites W1987577479 @default.
- W3201934781 cites W1991236145 @default.
- W3201934781 cites W2066467155 @default.
- W3201934781 cites W2080686146 @default.
- W3201934781 cites W2094953205 @default.
- W3201934781 cites W2096251377 @default.
- W3201934781 cites W2097021317 @default.
- W3201934781 cites W2128035403 @default.
- W3201934781 cites W2128327828 @default.
- W3201934781 cites W2135925159 @default.
- W3201934781 cites W2138074723 @default.
- W3201934781 cites W2147960762 @default.
- W3201934781 cites W2163188200 @default.
- W3201934781 cites W2166262263 @default.
- W3201934781 cites W2170839278 @default.
- W3201934781 cites W2177664658 @default.
- W3201934781 cites W2183840686 @default.
- W3201934781 cites W2223921723 @default.
- W3201934781 cites W2335844855 @default.
- W3201934781 cites W2418637363 @default.
- W3201934781 cites W2571465038 @default.
- W3201934781 hasPublicationYear "2017" @default.
- W3201934781 type Work @default.
- W3201934781 sameAs 3201934781 @default.
- W3201934781 citedByCount "0" @default.
- W3201934781 crossrefType "journal-article" @default.
- W3201934781 hasAuthorship W3201934781A5049365649 @default.
- W3201934781 hasConcept C104317684 @default.
- W3201934781 hasConcept C121608353 @default.
- W3201934781 hasConcept C126322002 @default.
- W3201934781 hasConcept C184235292 @default.
- W3201934781 hasConcept C2776131300 @default.
- W3201934781 hasConcept C2776470698 @default.
- W3201934781 hasConcept C2777658100 @default.
- W3201934781 hasConcept C2778472372 @default.
- W3201934781 hasConcept C2778830669 @default.
- W3201934781 hasConcept C2781018059 @default.
- W3201934781 hasConcept C2781249067 @default.
- W3201934781 hasConcept C29537977 @default.
- W3201934781 hasConcept C2994587330 @default.
- W3201934781 hasConcept C501734568 @default.
- W3201934781 hasConcept C502942594 @default.
- W3201934781 hasConcept C55493867 @default.
- W3201934781 hasConcept C57074206 @default.
- W3201934781 hasConcept C71924100 @default.
- W3201934781 hasConcept C86803240 @default.
- W3201934781 hasConceptScore W3201934781C104317684 @default.
- W3201934781 hasConceptScore W3201934781C121608353 @default.
- W3201934781 hasConceptScore W3201934781C126322002 @default.
- W3201934781 hasConceptScore W3201934781C184235292 @default.
- W3201934781 hasConceptScore W3201934781C2776131300 @default.
- W3201934781 hasConceptScore W3201934781C2776470698 @default.
- W3201934781 hasConceptScore W3201934781C2777658100 @default.
- W3201934781 hasConceptScore W3201934781C2778472372 @default.
- W3201934781 hasConceptScore W3201934781C2778830669 @default.
- W3201934781 hasConceptScore W3201934781C2781018059 @default.
- W3201934781 hasConceptScore W3201934781C2781249067 @default.
- W3201934781 hasConceptScore W3201934781C29537977 @default.
- W3201934781 hasConceptScore W3201934781C2994587330 @default.
- W3201934781 hasConceptScore W3201934781C501734568 @default.
- W3201934781 hasConceptScore W3201934781C502942594 @default.
- W3201934781 hasConceptScore W3201934781C55493867 @default.
- W3201934781 hasConceptScore W3201934781C57074206 @default.
- W3201934781 hasConceptScore W3201934781C71924100 @default.
- W3201934781 hasConceptScore W3201934781C86803240 @default.
- W3201934781 hasLocation W32019347811 @default.
- W3201934781 hasOpenAccess W3201934781 @default.
- W3201934781 hasPrimaryLocation W32019347811 @default.
- W3201934781 isParatext "false" @default.
- W3201934781 isRetracted "false" @default.
- W3201934781 magId "3201934781" @default.
- W3201934781 workType "article" @default.