Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201958052> ?p ?o ?g. }
- W3201958052 abstract "Gonadal steroid 17β-estradiol (E2) exerts rapid, non-genomic effects on neurons and strictly regulates learning and memory through altering glutamatergic neurotransmission and synaptic plasticity. However, its non-genomic effects on AMPARs are not well understood. Here, we analyzed the rapid effect of E2 on AMPARs using single-molecule tracking and super-resolution imaging techniques. We found that E2 rapidly decreased the surface movement of AMPAR via membrane G protein-coupled estrogen receptor 1 (GPER1) in neurites in a dose-dependent manner. The cortical actin network played a pivotal role in the GPER1 mediated effects of E2 on the surface mobility of AMPAR. E2 also decreased the surface movement of AMPAR both in synaptic and extrasynaptic regions on neurites and increased the synaptic dwell time of AMPARs. Our results provide evidence for understanding E2 action on neuronal plasticity and glutamatergic neurotransmission at the molecular level." @default.
- W3201958052 created "2021-10-11" @default.
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- W3201958052 date "2021-09-23" @default.
- W3201958052 modified "2023-10-18" @default.
- W3201958052 title "Single-Molecule Imaging Reveals Rapid Estradiol Action on the Surface Movement of AMPA Receptors in Live Neurons" @default.
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- W3201958052 doi "https://doi.org/10.3389/fcell.2021.708715" @default.
- W3201958052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8495425" @default.
- W3201958052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34631701" @default.
- W3201958052 hasPublicationYear "2021" @default.
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