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- W3201960420 endingPage "5790" @default.
- W3201960420 startingPage "5790" @default.
- W3201960420 abstract "L-DOPA therapy in Parkinson’s disease (PD) is limited due to emerging L-DOPA-induced dyskinesia. Research has identified abnormal dopamine release from serotonergic (5-HT) terminals contributing to this dyskinesia. Selective serotonin reuptake inhibitors (SSRIs) or 5-HT receptor (5-HTr) agonists can regulate 5-HT activity and attenuate dyskinesia, but they often also produce a loss of the antiparkinsonian efficacy of L-DOPA. We investigated vilazodone, a novel multimodal 5-HT agent with SSRI and 5-HTr1A partial agonist properties, for its potential to reduce dyskinesia without interfering with the prokinetic effects of L-DOPA, and underlying mechanisms. We assessed vilazodone effects on L-DOPA-induced dyskinesia (abnormal involuntary movements, AIMs) and aberrant responsiveness to corticostriatal drive in striatal medium spiny neurons (MSNs) measured with in vivo single-unit extracellular recordings, in the 6-OHDA rat model of PD. Vilazodone (10 mg/kg) suppressed all subtypes (axial, limb, orolingual) of AIMs induced by L-DOPA (5 mg/kg) and the increase in MSN responsiveness to cortical stimulation (shorter spike onset latency). Both the antidyskinetic effects and reversal in MSN excitability by vilazodone were inhibited by the 5-HTr1A antagonist WAY-100635, demonstrating a critical role for 5-HTr1A in these vilazodone actions. Our results indicate that vilazodone may serve as an adjunct therapeutic for reducing dyskinesia in patients with PD." @default.
- W3201960420 created "2021-10-11" @default.
- W3201960420 creator A5023896348 @default.
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- W3201960420 creator A5061592030 @default.
- W3201960420 creator A5080213200 @default.
- W3201960420 date "2021-09-24" @default.
- W3201960420 modified "2023-09-27" @default.
- W3201960420 title "Role of 5-HT1A Receptor in Vilazodone-Mediated Suppression of L-DOPA-Induced Dyskinesia and Increased Responsiveness to Cortical Input in Striatal Medium Spiny Neurons in an Animal Model of Parkinson’s Disease" @default.
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- W3201960420 doi "https://doi.org/10.3390/molecules26195790" @default.
- W3201960420 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8510243" @default.
- W3201960420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34641332" @default.
- W3201960420 hasPublicationYear "2021" @default.
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