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• W3201977260 endingPage "119983" @default.
• W3201977260 startingPage "119983" @default.
• W3201977260 abstract "Modern dietary habits have been associated with Nonalcoholic Steatohepatitis (NASH). Curcumin is a natural herbal found to suppress cellular oxidative states and could be beneficial in NASH. This study investigates the effect of curcumin in an animal model of NASH.Fifty rats were allocated into five groups. Control, High Fat Diet (HFD), curcumin prophylactic (CP) and therapeutic (CT) groups. HFD regimen was given for 16 weeks. Curcumin was given along with HFD (prophylactic) or after establishment of the model for two weeks (therapeutic). Livers and blood samples were harvested for histological, biochemical, and molecular studies.Livers from HFD groups showed vascular, inflammatory, cellular degenerative and fibrotic changes. The hepatic damage was reflected by the increased serum liver enzymes. HFD groups showed excessive fibrotic change. Interestingly, curcumin administration as prophylactic or therapeutic significantly preserved and/or restored liver structure. This was evidenced by the normalization of the liver enzymes, preservation and/or reversibility of cellular changes and the decrease of the stage of fibrosis. Nuclear factor E2-related factor 2 gene (Nrf2) expression showed no changes in the HFD groups, however it showed upregulation in curcumin treated groups. Thus, the protective and therapeutic effect of curcumin could be induced through upregulation of the Nrf2 gene. Curcumin has a beneficial prophylactic and therapeutic effect that could hinder the development and/or treat NASH in susceptible livers.Curcumin has a beneficial prophylactic and therapeutic effect that could hinder the development and/or treat NASH in susceptible livers." @default.
• W3201977260 created "2021-10-11" @default.
• W3201977260 creator A5025428504 @default.
• W3201977260 creator A5043436511 @default.
• W3201977260 creator A5063722285 @default.
• W3201977260 creator A5072774474 @default.
• W3201977260 creator A5088832581 @default.
• W3201977260 date "2021-11-01" @default.
• W3201977260 modified "2023-10-10" @default.
• W3201977260 title "Curcumin activation of nuclear factor E2-related factor 2 gene (Nrf2): Prophylactic and therapeutic effect in nonalcoholic steatohepatitis (NASH)" @default.
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• W3201977260 doi "https://doi.org/10.1016/j.lfs.2021.119983" @default.
• W3201977260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34599938" @default.

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