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• W3201980339 abstract "Hematopoietic stem cell (HSC) transplantation persists as the most successful andeffective curative therapy for many haematological and non-haematological diseases,and cord blood HSCs have considerable advantages compared to other sources. Thelow number of cells harvested restricts their use and hence successful engraftment ishighly dependent on the quality and quantity of stem cells and nucleated cells in cordblood. Forasmuch, the higher costs of cryopreservation that is needed to store theblood units, it is important to determine the maternal and neonatal factors, whichinclude maternal illnesses that influence the higher yield of hematopoietic stem cellsobtained from umbilical cord blood. Hence, a wise decision of storing UCB for thedefinitive aim of successful cells engraftment can be made. This study evaluated theeffect of mild Gestational Diabetes Mellitus (mGDM) on the quality and quantity ofUCB parameters in terms of CD34+ cell count and viability, a total number ofnucleated cells and cord blood volume.130 samples of umbilical cord blood collected from Malaysian women who deliveredtheir babies at Hospital Serdang between May 2016 and April 2017 were collected;63 were mGDM and 67 were from healthy women. The harvesting of the umbilicalcord blood was performed via the in utero method. The UCB samples analysis includethe total UCB collected volume, total nucleated cell (TNC) count, and CD34+ cellcount by flow cytometry following the ISHAGE protocol and the measurement of theviability resorting to the nucleic acid marker 7-amino actinomycin D.There was a significant statistical association between the healthy group and mGDMwomen group in terms of UCB unit volume and TNC number and viability. The meanUCB volume for healthy women was 60.88 ± 18.16, while it was 54.06 ± 19.40 inmGDM women (p = 0.041). The mean of TNCs was 54.84 ± 26.79, 44.42 ± 24.13 andviability of TNCs was 53.71 ± 25.52, 42.88 ± 24.12 (p = 0.022 and 0.014) for healthywomen and mGDM women respectively. Nevertheless, the analysis of CD34+ countand its viability between the two groups yielded no significant statistical difference.On the other hand, the means of CD34+ percentage in mGDM (0.16 ± 0.19) wasstatistically significant when compared to healthy group (0.11 ± 0.10) with p = 0.027,which reflect that mGDM, yielded a higher % of CD34+. The correlation coefficientsfor CD34+ indicated a significant and positive relationship between placental weightand CD34+ cells counts (r = 0.572, p < 0.001), CD34+ viability (r = 0.279, p = 0.027),and CD34+ percent (r = 0.422, p = 0.001). UCB volume and TNCs count and viabilityare highly significantly related to the placental weight when r correlation coefficientvalues were 0.438 (p < 0.0010), 0.3810 (p = 0.002), and 0.382 (p = 0.002) respectively.On contrary, in the healthy group, placental weight only correlates to CB volume andTNC number with r = 0.288 (p = 0.019) and 0.246 (p = 0.047) respectively. The studyrevealed that gender has no significant impact on all UCB parameters regardlessmothers of mGDM group or healthy group as (p > 0.05). Infant’s birth weight in themGDM group has a positive correlation with UCB volume, TNC count and viability,but not CD34+ parameters (count, viability and percentage) (p > 0.05). As comparedto neonates with normal birth weight (NBW) have higher blood volume, TNC countand viability, than low birth weight (LBW) neonates (p = 0.007, 0.010, 0.013). In thehealthy group, all UCB parameters are not affected whether neonates are NBW orLBW (p > 0.05). In conclusion, mGDM has a negative impact on the UCB volume and TNC count andviability obtained from cord blood at delivery, but not on the yield of HSC. Placentalweight and neonatal birth weight are the most important factors influencing thenumbers of cord blood HSC. These findings would provide guidance to mothers who are GDM on diet control and to their health care providers in making the right decision regarding UCB stem cell collection and banking." @default.
• W3201980339 created "2021-10-11" @default.
• W3201980339 creator A5037459105 @default.
• W3201980339 date "2018-10-01" @default.
• W3201980339 modified "2023-09-27" @default.
• W3201980339 title "Effects of mild gestational diabetes mellitus on quality of umbilical cord blood hematopoietic stem cells procured at delivery" @default.
• W3201980339 hasPublicationYear "2018" @default.
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