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• W3201989709 abstract "<h3>Introduction</h3> Tissue characterization using cardiac magnetic resonance (CMR) imaging has the potential to delineate early signs of inflammatory cardiomyopathy. Recent CMR studies in patients recovered from SARS-CoV-2 patients suggested a high prevalence of abnormal findings on CMR, including lower left ventricular ejection fraction, higher left ventricle volumes, and raised native T1 and T2 signal values. Concerns persist, however, regarding the influence of selection bias for inclusion into studies. <h3>Methods</h3> The Study of HEarT DiseAse and ImmuNiTy After COVID-19 in Ireland (SETANTA) is a prospective, community-based, observational, cross-sectional population study investigating the incidence of cardiac abnormalities as assessed by CMR imaging in 100 participants recruited from general practice following acute SARS-CoV-2 infection and evaluating correlation with immunological response and presence and extent of coagulopathy. Consecutive patients with recent COVID-19 infection (≥ 6 weeks and ≤ 12 months) as evidenced by positive reverse-transcriptase polymerase chain reaction (RT-PCR) were identified from two primary care sites and invited to participate in the study. At inclusion, written informed consent, followed by baseline clinical data and blood collection, ECG and holter monitor recording and perfusion CMR imaging will be performed for all included participants. Follow-up assessment of major adverse cardiovascular events (MACE), comprised of myocardial infarction, revascularization, pulmonary embolism, deep venous thromboembolism, heart failure or stroke will be performed at 1, 6- and 12-months after inclusion. Patient reported outcome measures using a modified Seattle Angina (SAQ7) and the EuroQol (EQ-5D-5L) questionnaires will be assessed at inclusion as well as at 6- and 12-month follow-up. Primary and secondary endpoints of the study, inclusion/exclusion criteria and study flow are depicted in detail in figure 1. The study is funded by the Cardiovascular Research Institute Dublin, Mater Private Network and Women As One. The study is registered at www.clinicaltrials.gov (study identifier: NCT04823182). <h3>Results</h3> A pilot study of 30 patients has completed enrolment. Full cohort (n=100) enrolment and analysis will be completed by September 2021. Primary results of the full cohort study will be available to be presented during the Annual Scientific Meeting of Irish Cardiac Society. <h3>Conclusion</h3> The SETANTA study will evaluate the prevalence and characteristics of abnormalities on cardiac MRI in primary care patients in Ireland following recovery from acute SARS-CoV-2 infection and assess correlation with immune response and coagulopathy. Data from the study will help inform the long-term management of patients recovered from SARS-CoV-2 and assist in planning of health care service provision." @default.
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• W3201989709 date "2021-10-01" @default.
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• W3201989709 title "32 Prevalence and characteristics of abnormalities on cardiac MRI in primary care following recovery from acute SARS-CoV-2 infection and correlation with markers of immunity and coagulation: primary results of the setanta study" @default.
• W3201989709 doi "https://doi.org/10.1136/heartjnl-2021-ics.32" @default.
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