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- W3201991197 abstract "Renal cysts and diabetes (RCAD) syndrome is an autosomal dominant diabetic renal disease. Precise molecular diagnosis of RCAD syndrome has proven valuable for understanding its mechanism and personalized therapy.A RCAD patient and her family were studied to investigate potential responsible genes by the whole exome sequencing (WES). Candidate pathogenic variants were validated by Sanger sequencing. The clinical characteristics of RCAD patient were collected from medical records. Unlike those typical RCAD patients, we observed renal manifestation and prediabetes phenotype, but not reproductive organ phenotype and hypomagnesaemia. A novel 7-bp deletion mutation in exon 4 of the hepatocyte nuclear factor 1B, NM_000458: c.882_888del (p.V294fs), was identified by WES and confirmed by Sanger sequencing.This novel mutation identified in a Chinese family with RCAD syndrome might be the molecular pathogenic basis of this disorder." @default.
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- W3201991197 date "2021-10-06" @default.
- W3201991197 modified "2023-10-01" @default.
- W3201991197 title "Hepatocyte nuclear factor 1B mutation in a Chinese family with renal cysts and diabetes syndrome: A case report" @default.
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- W3201991197 doi "https://doi.org/10.12998/wjcc.v9.i28.8461" @default.
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