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• W3201993007 abstract "In pediatrics, glomerular filtration rate (GFR) may be estimated by measured corrected creatinine clearance (mcCrCl) (mL/min/1.73 m2) or the Schwartz formula (eGFR = height/plasma creatinine x k). The constant k depends on the plasma creatinine determination method: k = 0.55 for the Jaffe colorimetric method and k = 0.413 for the enzymatic method. Our laboratory uses the compensated kinetic colorimetric assay (CKC), and differences are observed between the estimated and measured GFR. Hypothesis: The proposed values of k do not adjust to the CKC method for plasma creatinine.To calculate a k value that allows to estimate GFR through creatinine measurement with CKC.Correlational, descriptive design. Patients aged 3-18 years seen at the Division of Pediatric Nephrology between July 2017 and January 2018 with normal or altered GFR, bladder and bowel control, and signed consent were included. Malnourished and myelomeningocele patients were excluded. Studied variables were plasma and urine creatinine, height, and 24-hour urine output.A total of 184 patients were analyzed, their mean age was 10 years. Median mcCrCl was 123 mL/min/1.73 m2. The linear correlation between height and plasma creatinine and mcCrCl resulted in a k value of 0.499 (r = 0.974 and r2 = 0.949). The linear correlation between the estimated GFR (k = 0.499) and mcCrCl resulted in a 0.999 ß coefficient (r = 0.951 and r2 = 0.903).According to this study, the constant that allows to estimate GFR when measuring plasma creatinine with the CKC method is 0.499.Introducción. En pediatría, el filtrado glomerular (FG) se puede calcular con el clearance (depuración) de creatinina medida corregida en ml/min/1,73 m2, o se puede estimar según la fórmula de Schwartz (FGe = talla/ creatinina plasmática x k). La constante k depende del método de determinación de creatinina plasmática: k = 0,55 para el método colorimétrico de Jaffe, y k =0,413 para el método enzimático. Nuestro laboratorio utiliza el método colorimétrico cinético compensado (MCCC), se observan discordancias entre el FG estimado y el medido. Hipótesis: Los valores de k propuestos no se ajustan al MCCC de creatinina plasmática. Objetivo. Calcular el valor de k que permita estimar el FG mediante la cuantificación de la creatinina con el MCCC. Métodos. Diseño descriptivo correlacional. Se incluyeron pacientes de entre 3 y 18 años con FG normal o alterado atendidos en el Servicio de Nefrología Infantil entre julio de 2017 y enero de 2018 con control de esfínteres y firma del consentimiento. Se excluyeron pacientes desnutridos y con mielomeningocele. Las variables estudiadas fueron: creatinina plasmática y urinaria, talla y diuresis de 24 horas. Resultados. Se analizaron 184 pacientes, con una edad media de 10 años. La mediana del clearance de creatinina medido corregido fue de 123 ml/ min/1,73 m2. La correlación lineal entre la talla y la creatinina plasmática y el clearance de creatinina medido corregido arrojó un valor de k de 0,499 (r = 0,974 y r2 = 0,949). La correlación lineal entre el FG estimado (k = 0,499) y el clearance de creatinina medido corregido mostró un coeficiente b = 0,999 (r = 0,951 y r2= 0,903). Conclusión. Según este estudio, la constante que permite estimar el filtrado glomerular al cuantificar la creatinina plasmática con el método colorimétrico cinético compensado es de 0,499." @default.
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• W3201993007 date "2021-10-01" @default.
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• W3201993007 title "Determination of a new constant to estimate glomerular filtration rate in pediatrics" @default.
• W3201993007 doi "https://doi.org/10.5546/aap.2021.eng.e428" @default.
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