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- W3201997824 abstract "Parkinson's disease (PD) is a progressive neurodegenerative disease with no satisfactory therapy options. Similar to other neurodegenerative conditions, such as Alzheimer's and Huntington's diseases, oxidative stress plays a key factor in the neurodegeneration process. To counteract the uncontrolled increase of reactive oxygen species (ROS) and oxidative stress-dependent cell death, several preclinical and clinical tests exploit natural-derived organic antioxidants, such as polyphenols. Despite some promising results, free antioxidants show scarce brain accumulation and may exhaust their scavenging activity before reaching the brain. In this work, we developed an antioxidant therapeutic nanoplatform consisting of nano-sized functionalized liposomes loaded with selected polyphenol-rich vegetal extracts with high blood-brain barrier crossing capabilities. The antioxidant extracts were obtained from the grape seeds and skins as a byproduct of wine production (i.e., pomace), following a sustainable circular approach with reduced environmental impact. The antioxidant nanoplatform was successfully tested in a relevant in vitro model of PD, where it completely rescued the ROS levels, prevented the aggregation of α-synuclein fibrils, and restored cell viability, paving the way for preclinical translation of the approach." @default.
- W3201997824 created "2021-10-11" @default.
- W3201997824 creator A5050847152 @default.
- W3201997824 creator A5068904717 @default.
- W3201997824 creator A5069954244 @default.
- W3201997824 creator A5078435217 @default.
- W3201997824 creator A5083711626 @default.
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- W3201997824 creator A5091743561 @default.
- W3201997824 date "2021-01-01" @default.
- W3201997824 modified "2023-10-16" @default.
- W3201997824 title "Liposomes loaded with polyphenol-rich grape pomace extracts protect from neurodegeneration in a rotenone-based <i>in vitro</i> model of Parkinson's disease" @default.
- W3201997824 cites W1008398044 @default.
- W3201997824 cites W1504584187 @default.
- W3201997824 cites W1511957901 @default.
- W3201997824 cites W1549213315 @default.
- W3201997824 cites W1588570886 @default.
- W3201997824 cites W1930159471 @default.
- W3201997824 cites W1965351947 @default.
- W3201997824 cites W1970094644 @default.
- W3201997824 cites W1975394561 @default.
- W3201997824 cites W1979883589 @default.
- W3201997824 cites W1989230986 @default.
- W3201997824 cites W2002739405 @default.
- W3201997824 cites W2008784665 @default.
- W3201997824 cites W2015950177 @default.
- W3201997824 cites W2016927879 @default.
- W3201997824 cites W2022060012 @default.
- W3201997824 cites W2027432937 @default.
- W3201997824 cites W2033898136 @default.
- W3201997824 cites W2041504874 @default.
- W3201997824 cites W2055937873 @default.
- W3201997824 cites W2062605045 @default.
- W3201997824 cites W2063856198 @default.
- W3201997824 cites W2071041805 @default.
- W3201997824 cites W2075542858 @default.
- W3201997824 cites W2078424158 @default.
- W3201997824 cites W2084342405 @default.
- W3201997824 cites W2091099722 @default.
- W3201997824 cites W2094655287 @default.
- W3201997824 cites W2095213976 @default.
- W3201997824 cites W2100218154 @default.
- W3201997824 cites W2101099825 @default.
- W3201997824 cites W2106574442 @default.
- W3201997824 cites W2121304044 @default.
- W3201997824 cites W2151704931 @default.
- W3201997824 cites W2156241187 @default.
- W3201997824 cites W2159821105 @default.
- W3201997824 cites W2262412919 @default.
- W3201997824 cites W2317239307 @default.
- W3201997824 cites W2549976854 @default.
- W3201997824 cites W2553258327 @default.
- W3201997824 cites W2565231603 @default.
- W3201997824 cites W2565677516 @default.
- W3201997824 cites W2573958866 @default.
- W3201997824 cites W2584311212 @default.
- W3201997824 cites W2591025507 @default.
- W3201997824 cites W2599603205 @default.
- W3201997824 cites W2604140695 @default.
- W3201997824 cites W2737477331 @default.
- W3201997824 cites W2746957719 @default.
- W3201997824 cites W2768052566 @default.
- W3201997824 cites W2788808587 @default.
- W3201997824 cites W2790852710 @default.
- W3201997824 cites W2793316741 @default.
- W3201997824 cites W2884392393 @default.
- W3201997824 cites W2887364005 @default.
- W3201997824 cites W2895525350 @default.
- W3201997824 cites W2923862917 @default.
- W3201997824 cites W2969375518 @default.
- W3201997824 cites W2976817835 @default.
- W3201997824 cites W2981321543 @default.
- W3201997824 cites W2989708402 @default.
- W3201997824 cites W2996560798 @default.
- W3201997824 cites W3005107782 @default.
- W3201997824 cites W3007880325 @default.
- W3201997824 cites W3041812301 @default.
- W3201997824 cites W3075406905 @default.
- W3201997824 cites W3080380909 @default.
- W3201997824 cites W3081535596 @default.
- W3201997824 cites W3086303985 @default.
- W3201997824 cites W3088637818 @default.
- W3201997824 cites W3093615285 @default.
- W3201997824 cites W3104314256 @default.
- W3201997824 cites W3104389503 @default.
- W3201997824 cites W3116710067 @default.
- W3201997824 cites W3119130970 @default.
- W3201997824 cites W3120987125 @default.
- W3201997824 cites W3123220288 @default.
- W3201997824 cites W3127249110 @default.
- W3201997824 cites W3129289862 @default.
- W3201997824 cites W3134086869 @default.
- W3201997824 cites W3134629751 @default.
- W3201997824 doi "https://doi.org/10.1039/d1bm01202a" @default.
- W3201997824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34617936" @default.
- W3201997824 hasPublicationYear "2021" @default.
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