FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201998196> ?p ?o ?g. }

• W3201998196 endingPage "S715" @default.
• W3201998196 startingPage "S714" @default.
• W3201998196 abstract "Purpose or Objective During the COVID-19 pandemic, health insurance providers permitted to treat esophageal cancer (EC) patients with proton therapy (PT) when treated in the neo-adjuvant setting. This decision was based on the results of the MD Anderson randomized study showing significantly lower rates of the Total Toxicity Burden (TTB), especially of postoperative toxicity and consequently decreased hospital and intensive care unit (ICU) stay. The TTB combines a large range of toxicities with different incidence rates and severities into a single sum score. For patient selection, we used a model-based approach (MBA) using a model for TTB (>60). The aim of this study was to investigate if the post-operative TTB decreased with PT. Materials and Methods In accordance with the MBA, a plan comparison (photon vs proton radiotherapy (RT)) was performed in all EC patients that were to be treated with neo-adjuvant chemoradiotherapy (nCRT) according to the CROSS regimen. For patient selection, we developed a normal tissue complication probability (NTCP)-model for a TTB > 60, which corresponds to at least one grade > III or 2 grade > II complications. Patients, who were eligible for PT in terms of target motion ( 5%, were selected and treated with PT. Postoperative TTB and hospital and ICU stay were compared with a prospective dataset of patients that were treated with photon RT between 2014 and 2018 (n=224). Results Since March 2020, 26 out of 32 patients were selected for PT. The average reduction in mean lung dose was 5.2 Gy with PT compared to VMAT, with a corresponding average NTCP-reduction for TTB of 9.7%. Mean heart, spleen and liver dose were reduced by 7.9, 7.4 and 7.1 Gy, respectively. At the time of analyses, 14 out of 19 patients underwent esophagectomy. Three patients developed intercurrent metastases, in one a wait and see policy was applied and one switched to definitive CRT. In the resected PT patients, the expected proportion of patients with a TTB>60 was 29.7% for photon and 20.8% for proton RT. After resection, only one out of 14 patients (7.1%) had an TTB>60 ((p=0.051), compared to the expected proportion based on the photon plans). On average, the observed post-operative TTB was 15 (SEM: 6) after PT, compared to the historical photon cohort in which the observed post-operative TTB was 45 (SEM: 5). Hospital and ICU stay were also reduced by PT compared to the photon cohort;12.7 (SEM 1.4) vs. 20.0 (SEM 1.2) and 1.9 days (SEM 0.4) vs. 4.9 (SEM 0.6), resulting in an average cost reduction of about 10,000 euro per patient. Follow up will continuously be updated in our dynamic database. Conclusion In the neo-adjuvant setting, the first results indicate that proton-based nCRT reduces the post-operative TTB compared to historic photon-based nCRT. Moreover, there seems to be a trend towards reduced hospital and ICU stay." @default.
• W3201998196 created "2021-10-11" @default.
• W3201998196 creator A5000010158 @default.
• W3201998196 creator A5001642534 @default.
• W3201998196 creator A5005251920 @default.
• W3201998196 creator A5005852149 @default.
• W3201998196 creator A5045738703 @default.
• W3201998196 creator A5055098897 @default.
• W3201998196 creator A5069820721 @default.
• W3201998196 creator A5076011559 @default.
• W3201998196 creator A5085307933 @default.
• W3201998196 creator A5087968350 @default.
• W3201998196 creator A5060519519 @default.
• W3201998196 date "2021-08-01" @default.
• W3201998196 modified "2023-09-26" @default.
• W3201998196 title "PD-0878 Reduction of post-operative toxicity in esophageal cancer patients after model based proton therapy" @default.
• W3201998196 doi "https://doi.org/10.1016/s0167-8140(21)07157-7" @default.
• W3201998196 hasPublicationYear "2021" @default.
• W3201998196 type Work @default.
• W3201998196 sameAs 3201998196 @default.
• W3201998196 citedByCount "1" @default.
• W3201998196 countsByYear W32019981962022 @default.
• W3201998196 crossrefType "journal-article" @default.
• W3201998196 hasAuthorship W3201998196A5000010158 @default.
• W3201998196 hasAuthorship W3201998196A5001642534 @default.
• W3201998196 hasAuthorship W3201998196A5005251920 @default.
• W3201998196 hasAuthorship W3201998196A5005852149 @default.
• W3201998196 hasAuthorship W3201998196A5045738703 @default.
• W3201998196 hasAuthorship W3201998196A5055098897 @default.
• W3201998196 hasAuthorship W3201998196A5060519519 @default.
• W3201998196 hasAuthorship W3201998196A5069820721 @default.
• W3201998196 hasAuthorship W3201998196A5076011559 @default.
• W3201998196 hasAuthorship W3201998196A5085307933 @default.
• W3201998196 hasAuthorship W3201998196A5087968350 @default.
• W3201998196 hasConcept C111335779 @default.
• W3201998196 hasConcept C121608353 @default.
• W3201998196 hasConcept C126322002 @default.
• W3201998196 hasConcept C143998085 @default.
• W3201998196 hasConcept C2524010 @default.
• W3201998196 hasConcept C2779244869 @default.
• W3201998196 hasConcept C2779742542 @default.
• W3201998196 hasConcept C29730261 @default.
• W3201998196 hasConcept C33923547 @default.
• W3201998196 hasConcept C509974204 @default.
• W3201998196 hasConcept C71924100 @default.
• W3201998196 hasConceptScore W3201998196C111335779 @default.
• W3201998196 hasConceptScore W3201998196C121608353 @default.
• W3201998196 hasConceptScore W3201998196C126322002 @default.
• W3201998196 hasConceptScore W3201998196C143998085 @default.
• W3201998196 hasConceptScore W3201998196C2524010 @default.
• W3201998196 hasConceptScore W3201998196C2779244869 @default.
• W3201998196 hasConceptScore W3201998196C2779742542 @default.
• W3201998196 hasConceptScore W3201998196C29730261 @default.
• W3201998196 hasConceptScore W3201998196C33923547 @default.
• W3201998196 hasConceptScore W3201998196C509974204 @default.
• W3201998196 hasConceptScore W3201998196C71924100 @default.
• W3201998196 hasLocation W32019981961 @default.
• W3201998196 hasOpenAccess W3201998196 @default.
• W3201998196 hasPrimaryLocation W32019981961 @default.
• W3201998196 hasRelatedWork W1511246213 @default.
• W3201998196 hasRelatedWork W2033287347 @default.
• W3201998196 hasRelatedWork W2084845148 @default.
• W3201998196 hasRelatedWork W2275543989 @default.
• W3201998196 hasRelatedWork W2329970783 @default.
• W3201998196 hasRelatedWork W2330428980 @default.
• W3201998196 hasRelatedWork W2353164399 @default.
• W3201998196 hasRelatedWork W2388047550 @default.
• W3201998196 hasRelatedWork W2389086225 @default.
• W3201998196 hasRelatedWork W2801303331 @default.
• W3201998196 hasVolume "161" @default.
• W3201998196 isParatext "false" @default.
• W3201998196 isRetracted "false" @default.
• W3201998196 magId "3201998196" @default.
• W3201998196 workType "article" @default.