Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202005972> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W3202005972 abstract "Abstract BackgroundNatalizumab (NTZ) has been used for treatment of highly active relapsing-remitting multiple sclerosis (MS). When stopping NTZ the risk of severe rebound phenomenon has to be considered. We aimed to investigate the use of NTZ in clinical routine and focused on identification of potential risk factors for disease reactivation after treatment discontinuation.MethodsAt the Medical University of Innsbruck, Austria, we identified all MS patients who were treated with NTZ and performed a retrospective analysis on therapeutic decision making, disease course before, during and after treatment with NTZ and on risk factors for disease reactivation after NTZ discontinuation.Results235 NTZ treated MS patients were included, of whom 105 had discontinued treatment. At NTZ start disease duration was 5.09 (IQR 2.09-10.57) years, average number of total relapses was 4 (IQR 3-6) and median EDSS 2.0 (range 0-6.5), whereby these values significantly decreased over time. Reduction of annualized relapse rate (ARR) on treatment was 93% and EDSS remained stable in 64%. In a multivariate regression model only conversion to secondary progressive MS (SPMS) on treatment was significantly associated with lower risk of disease reactivation after NTZ, while ARR before treatment was associated with earlier disease reactivation. ConclusionsWe could confirm the high therapeutic efficacy of NTZ which trends to be used earlier in the disease course nowadays. Discontinuation of NTZ seems safe only in patients who convert to SPMS during treatment, while higher ARR before NTZ increases the risk of disease reactivation after treatment discontinuation." @default.
- W3202005972 created "2021-10-11" @default.
- W3202005972 creator A5002292654 @default.
- W3202005972 creator A5003343417 @default.
- W3202005972 creator A5012263587 @default.
- W3202005972 creator A5014894550 @default.
- W3202005972 creator A5017955660 @default.
- W3202005972 creator A5037651315 @default.
- W3202005972 creator A5039495989 @default.
- W3202005972 creator A5056983959 @default.
- W3202005972 creator A5081070017 @default.
- W3202005972 creator A5091042345 @default.
- W3202005972 date "2021-09-30" @default.
- W3202005972 modified "2023-09-26" @default.
- W3202005972 title "Treatment of Multiple Sclerosis with Natalizumab: Experiences from a Real-Life Cohort Over 15 Years" @default.
- W3202005972 doi "https://doi.org/10.21203/rs.3.rs-924628/v1" @default.
- W3202005972 hasPublicationYear "2021" @default.
- W3202005972 type Work @default.
- W3202005972 sameAs 3202005972 @default.
- W3202005972 citedByCount "0" @default.
- W3202005972 crossrefType "posted-content" @default.
- W3202005972 hasAuthorship W3202005972A5002292654 @default.
- W3202005972 hasAuthorship W3202005972A5003343417 @default.
- W3202005972 hasAuthorship W3202005972A5012263587 @default.
- W3202005972 hasAuthorship W3202005972A5014894550 @default.
- W3202005972 hasAuthorship W3202005972A5017955660 @default.
- W3202005972 hasAuthorship W3202005972A5037651315 @default.
- W3202005972 hasAuthorship W3202005972A5039495989 @default.
- W3202005972 hasAuthorship W3202005972A5056983959 @default.
- W3202005972 hasAuthorship W3202005972A5081070017 @default.
- W3202005972 hasAuthorship W3202005972A5091042345 @default.
- W3202005972 hasBestOaLocation W32020059721 @default.
- W3202005972 hasConcept C126322002 @default.
- W3202005972 hasConcept C141071460 @default.
- W3202005972 hasConcept C167135981 @default.
- W3202005972 hasConcept C203014093 @default.
- W3202005972 hasConcept C2778715236 @default.
- W3202005972 hasConcept C2779134260 @default.
- W3202005972 hasConcept C2780640218 @default.
- W3202005972 hasConcept C2781004633 @default.
- W3202005972 hasConcept C71924100 @default.
- W3202005972 hasConceptScore W3202005972C126322002 @default.
- W3202005972 hasConceptScore W3202005972C141071460 @default.
- W3202005972 hasConceptScore W3202005972C167135981 @default.
- W3202005972 hasConceptScore W3202005972C203014093 @default.
- W3202005972 hasConceptScore W3202005972C2778715236 @default.
- W3202005972 hasConceptScore W3202005972C2779134260 @default.
- W3202005972 hasConceptScore W3202005972C2780640218 @default.
- W3202005972 hasConceptScore W3202005972C2781004633 @default.
- W3202005972 hasConceptScore W3202005972C71924100 @default.
- W3202005972 hasLocation W32020059721 @default.
- W3202005972 hasLocation W32020059722 @default.
- W3202005972 hasOpenAccess W3202005972 @default.
- W3202005972 hasPrimaryLocation W32020059721 @default.
- W3202005972 hasRelatedWork W1993552289 @default.
- W3202005972 hasRelatedWork W2020174931 @default.
- W3202005972 hasRelatedWork W2053771050 @default.
- W3202005972 hasRelatedWork W2082301205 @default.
- W3202005972 hasRelatedWork W2113157464 @default.
- W3202005972 hasRelatedWork W2192226300 @default.
- W3202005972 hasRelatedWork W2749256432 @default.
- W3202005972 hasRelatedWork W3157402828 @default.
- W3202005972 hasRelatedWork W4254560717 @default.
- W3202005972 hasRelatedWork W2264939213 @default.
- W3202005972 isParatext "false" @default.
- W3202005972 isRetracted "false" @default.
- W3202005972 magId "3202005972" @default.
- W3202005972 workType "article" @default.