Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202009088> ?p ?o ?g. }
- W3202009088 abstract "Our notions of protein function have long been determined by the protein structure–function paradigm. However, the idea that protein function is dictated by a prerequisite complementarity of shapes at the binding interface is becoming increasingly challenged. Interactions involving intrinsically disordered proteins (IDPs) have indicated a significant degree of disorder present in the bound state, ranging from static disorder to complete disorder, termed ‘random fuzziness’. This review assesses the anatomy of an IDP and relates how its intrinsic properties permit promiscuity and allow for the various modes of interaction. Furthermore, a mechanistic overview of the types of disordered domains is detailed, while also relating to a recent example and the kinetic and thermodynamic principles governing its formation." @default.
- W3202009088 created "2021-10-11" @default.
- W3202009088 creator A5028385706 @default.
- W3202009088 creator A5063651194 @default.
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- W3202009088 date "2021-10-01" @default.
- W3202009088 modified "2023-10-15" @default.
- W3202009088 title "Intrinsically disordered proteins: modes of binding with emphasis on disordered domains" @default.
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- W3202009088 doi "https://doi.org/10.1098/rsob.210222" @default.
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