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- W3202012147 abstract "The interaction between bacteriophages and integrins has been reported in different cancer cell lines, and efforts have been undertaken to understand these interactions in tumor cells along with their possible role in gene alterations, with the aim to develop new cancer therapies. Here, we report that the non-specific interaction of T4 and M13 bacteriophages with human PC-3 cells results in differential migration and varied expression of different integrins. PC-3 tumor cells (at 70% confluence) were exposed to 1 × 107 pfu/mL of either lytic T4 bacteriophage or filamentous M13 bacteriophage. After 24 h of exposure, cells were processed for a histochemical analysis, wound-healing migration assay, and gene expression profile using quantitative real-time PCR (qPCR). qPCR was performed to analyze the expression profiles of integrins ITGAV, ITGA5, ITGB1, ITGB3, and ITGB5. Our findings revealed that PC-3 cells interacted with T4 and M13 bacteriophages, with significant upregulation of ITGAV, ITGA5, ITGB3, ITGB5 genes after phage exposure. PC-3 cells also exhibited reduced migration activity when exposed to either T4 or M13 phages. These results suggest that wildtype bacteriophages interact non-specifically with PC-3 cells, thereby modulating the expression of integrin genes and affecting cell migration. Therefore, bacteriophages have future potential applications in anticancer therapies." @default.
- W3202012147 created "2021-10-11" @default.
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- W3202012147 date "2021-10-03" @default.
- W3202012147 modified "2023-10-15" @default.
- W3202012147 title "Exposure to Bacteriophages T4 and M13 Increases Integrin Gene Expression and Impairs Migration of Human PC-3 Prostate Cancer Cells" @default.
- W3202012147 cites W1141070425 @default.
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- W3202012147 cites W1902380478 @default.
- W3202012147 cites W1916922087 @default.
- W3202012147 cites W1917663794 @default.
- W3202012147 cites W1965526934 @default.
- W3202012147 cites W1984736888 @default.
- W3202012147 cites W1987568997 @default.
- W3202012147 cites W1996852043 @default.
- W3202012147 cites W2007725137 @default.
- W3202012147 cites W2015615249 @default.
- W3202012147 cites W2028039139 @default.
- W3202012147 cites W2029572050 @default.
- W3202012147 cites W2049851849 @default.
- W3202012147 cites W2052565988 @default.
- W3202012147 cites W2066611713 @default.
- W3202012147 cites W2077880808 @default.
- W3202012147 cites W2086486496 @default.
- W3202012147 cites W2088518437 @default.
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- W3202012147 cites W2149323915 @default.
- W3202012147 cites W2157826046 @default.
- W3202012147 cites W2161287613 @default.
- W3202012147 cites W2163253786 @default.
- W3202012147 cites W2187936164 @default.
- W3202012147 cites W2270895460 @default.
- W3202012147 cites W2272574501 @default.
- W3202012147 cites W2302188085 @default.
- W3202012147 cites W2317477512 @default.
- W3202012147 cites W2344850880 @default.
- W3202012147 cites W2347085671 @default.
- W3202012147 cites W2409985107 @default.
- W3202012147 cites W2415076785 @default.
- W3202012147 cites W2527276563 @default.
- W3202012147 cites W2584176612 @default.
- W3202012147 cites W2753110021 @default.
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- W3202012147 cites W2791820346 @default.
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- W3202012147 cites W2893355649 @default.
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- W3202012147 cites W2953049094 @default.
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- W3202012147 doi "https://doi.org/10.3390/antibiotics10101202" @default.
- W3202012147 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8532711" @default.
- W3202012147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34680783" @default.
- W3202012147 hasPublicationYear "2021" @default.
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