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- W3202012168 abstract "Asthma is a heterogeneous disease with respect to the inflammatory pathways that are activated.1 Recently, biologic agents targeting airway type 2 (T2) inflammation have been approved to treat uncontrolled T2 severe asthma.2 Among those agents, dupilumab, a monoclonal antibody directed toward the alpha subunit of the interleukin (IL)-4 receptor that blocks the signal transduction pathways activated by both IL-4 and IL-13, has recently become available.3 Several studies have documented the efficacy of dupilumab in reducing severe exacerbation rate and improving lung function in patients suffering from T2 moderate-to-severe asthma that remains uncontrolled despite optimal therapy." @default.
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- W3202012168 date "2022-02-01" @default.
- W3202012168 modified "2023-10-18" @default.
- W3202012168 title "A low FEV1 confounds interpretation of FeNO as an eligibility criterion for dupilumab" @default.
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- W3202012168 doi "https://doi.org/10.1016/j.jaip.2021.09.020" @default.
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