FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202016104> ?p ?o ?g. }

• W3202016104 abstract "Immune suppression after liver transplant for malignancy, such as hepatocellular carcinoma and end stage liver disease is done using immunosuppressant drugs like tacrolimus. As the immune system in children is not fully developed, combining immunosuppressants like glucocorticoids influence the efficacy and reduce the chances of transplant rejection, particularly in patients with gene polymorphism. However, whether interaction between glucocorticoid and tacrolimus is associated with CYP3A, MDR1, and PXR gene polymorphisms, remains unclear. Here, we explored correlations of synergistic effect of glucocorticoids on tacrolimus with CYP3A, MDR1 and PXR gene polymorphisms in pediatric patients receiving liver transplantation for malignancy and chronic liver disease. A total of 340 eligible children were divided into glucocorticoid (+) (n=148) and glucocorticoid () groups (n=192). They were given tacrolimus + mycophenolate mofetil, based on which glucocorticoid (+) group took prednisone acetate tablets for ≥12 months. The blood trough concentration of tacrolimus was detected by chemiluminescence microparticle immunoassay 1, 3, 6 and 12 months after medication, and blood drug concentration corrected by daily concentration/daily dose (C0/D) was calculated. CYP3A, MDR1 and PXR gene polymorphisms were analyzed using PCR-RFLP. GG, AG and AA genotypes of CYP3A were observed in 130, 166 and 44 cases, respectively. CC, CT and TT genotypes of MDR1 were found in 152, 142 and 46 cases, respectively. There were 252, 74 and 14 cases of WW, WM and MM genotypes of PXR, respectively. The distribution frequencies of GG and AG+AA genotypes had significant differences between the two groups. One month after medication, C0/D of tacrolimus of GG genotype in glucocorticoid (+) group significantly exceeded that of glucocorticoid () group. C0/D was significantly higher in glucocorticoid (+) group with AG+AA genotype1, 3, 6 and 12 months after medication (P <0.05)." @default.
• W3202016104 created "2021-10-11" @default.
• W3202016104 creator A5004609950 @default.
• W3202016104 creator A5040975375 @default.
• W3202016104 creator A5047534133 @default.
• W3202016104 date "2022-10-04" @default.
• W3202016104 modified "2023-09-26" @default.
• W3202016104 title "Correlations of synergistic effect of glucocorticoids on tacrolimus with CYP3A, MDR1 and PXR gene polymorphisms in pediatric patients receiving liver transplantation for malignancy and chronic liver disease" @default.
• W3202016104 doi "https://doi.org/10.56042/ijeb.v59i10.55793" @default.
• W3202016104 hasPublicationYear "2022" @default.
• W3202016104 type Work @default.
• W3202016104 sameAs 3202016104 @default.
• W3202016104 citedByCount "0" @default.
• W3202016104 crossrefType "journal-article" @default.
• W3202016104 hasAuthorship W3202016104A5004609950 @default.
• W3202016104 hasAuthorship W3202016104A5040975375 @default.
• W3202016104 hasAuthorship W3202016104A5047534133 @default.
• W3202016104 hasBestOaLocation W32020161041 @default.
• W3202016104 hasConcept C104317684 @default.
• W3202016104 hasConcept C11824378 @default.
• W3202016104 hasConcept C126322002 @default.
• W3202016104 hasConcept C132040763 @default.
• W3202016104 hasConcept C135763542 @default.
• W3202016104 hasConcept C203014093 @default.
• W3202016104 hasConcept C2779609443 @default.
• W3202016104 hasConcept C2780252810 @default.
• W3202016104 hasConcept C2780841215 @default.
• W3202016104 hasConcept C2909675724 @default.
• W3202016104 hasConcept C2911091166 @default.
• W3202016104 hasConcept C526171541 @default.
• W3202016104 hasConcept C55493867 @default.
• W3202016104 hasConcept C62231903 @default.
• W3202016104 hasConcept C63932345 @default.
• W3202016104 hasConcept C71924100 @default.
• W3202016104 hasConcept C86339819 @default.
• W3202016104 hasConcept C86803240 @default.
• W3202016104 hasConcept C90924648 @default.
• W3202016104 hasConcept C98274493 @default.
• W3202016104 hasConceptScore W3202016104C104317684 @default.
• W3202016104 hasConceptScore W3202016104C11824378 @default.
• W3202016104 hasConceptScore W3202016104C126322002 @default.
• W3202016104 hasConceptScore W3202016104C132040763 @default.
• W3202016104 hasConceptScore W3202016104C135763542 @default.
• W3202016104 hasConceptScore W3202016104C203014093 @default.
• W3202016104 hasConceptScore W3202016104C2779609443 @default.
• W3202016104 hasConceptScore W3202016104C2780252810 @default.
• W3202016104 hasConceptScore W3202016104C2780841215 @default.
• W3202016104 hasConceptScore W3202016104C2909675724 @default.
• W3202016104 hasConceptScore W3202016104C2911091166 @default.
• W3202016104 hasConceptScore W3202016104C526171541 @default.
• W3202016104 hasConceptScore W3202016104C55493867 @default.
• W3202016104 hasConceptScore W3202016104C62231903 @default.
• W3202016104 hasConceptScore W3202016104C63932345 @default.
• W3202016104 hasConceptScore W3202016104C71924100 @default.
• W3202016104 hasConceptScore W3202016104C86339819 @default.
• W3202016104 hasConceptScore W3202016104C86803240 @default.
• W3202016104 hasConceptScore W3202016104C90924648 @default.
• W3202016104 hasConceptScore W3202016104C98274493 @default.
• W3202016104 hasLocation W32020161041 @default.
• W3202016104 hasOpenAccess W3202016104 @default.
• W3202016104 hasPrimaryLocation W32020161041 @default.
• W3202016104 hasRelatedWork W1705018154 @default.
• W3202016104 hasRelatedWork W2003755555 @default.
• W3202016104 hasRelatedWork W2039925961 @default.
• W3202016104 hasRelatedWork W2056167279 @default.
• W3202016104 hasRelatedWork W2333478547 @default.
• W3202016104 hasRelatedWork W2347721723 @default.
• W3202016104 hasRelatedWork W2379658362 @default.
• W3202016104 hasRelatedWork W2413053858 @default.
• W3202016104 hasRelatedWork W3162771732 @default.
• W3202016104 hasRelatedWork W4254171834 @default.
• W3202016104 isParatext "false" @default.
• W3202016104 isRetracted "false" @default.
• W3202016104 magId "3202016104" @default.
• W3202016104 workType "article" @default.