FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202016208> ?p ?o ?g. }

• W3202016208 endingPage "436" @default.
• W3202016208 startingPage "420" @default.
• W3202016208 abstract "Previous studies have revealed the diverse neuroprotective effects of GV1001. In this study, we investigated the effects of GV1001 on focal cerebral ischemia-reperfusion injury (IRI) in rats and oxygen-glucose deprivation/reoxygenation (OGD/R)-induced injury in neural stem cells (NSCs) and cortical neurons.Focal cerebral IRI was induced by transient middle cerebral artery occlusion (MCAO). Brain diffusion-weighted imaging (DWI) was performed 2 hours after occlusion, and a total of 37 rats were treated by reperfusion with GV1001 or saline 2 hours after occlusion. Fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging, immunohistochemistry, and neurobehavioral function analyses were performed. Additionally, OGD/R-injured NSCs and cortical neurons were treated with different GV1001 concentrations. Cell viability, proliferation, migration, and oxidative stress were determined by diverse molecular analyses.In the stroke model, GV1001 protected neural cells against IRI. The most effective dose of GV1001 was 60 μM/kg. The infarct volume on FLAIR 48 hours after MCAO compared to lesion volume on DWI showed a significantly smaller ratio in the GV1001-treated group. GV1001-treated rats exhibited better behavioral functions than the saline-treated rats. Treatment with GV1001 increased the viability, proliferation, and migration of the OGD/R-injured NSCs. Free radicals were significantly restored by treatment with GV1001. These neuroprotective effects of GV1001 have also been demonstrated in OGD/R-injured cortical neurons.The results suggest that GV1001 has neuroprotective effects against IRI in NSCs, cortical neurons, and the rat brain. These effects are mediated through the induction of cellular proliferation, mitochondrial stabilization, and anti-apoptotic, anti-aging, and antioxidant effects." @default.
• W3202016208 created "2021-10-11" @default.
• W3202016208 creator A5001639544 @default.
• W3202016208 creator A5014833038 @default.
• W3202016208 creator A5028327919 @default.
• W3202016208 creator A5029089458 @default.
• W3202016208 creator A5034111842 @default.
• W3202016208 creator A5048277865 @default.
• W3202016208 creator A5054261442 @default.
• W3202016208 creator A5065085583 @default.
• W3202016208 creator A5091775106 @default.
• W3202016208 date "2021-09-30" @default.
• W3202016208 modified "2023-10-17" @default.
• W3202016208 title "Neuroprotective Effects of GV1001 in Animal Stroke Model and Neural Cells Subject to Oxygen-Glucose Deprivation/Reperfusion Injury" @default.
• W3202016208 cites W1508612083 @default.
• W3202016208 cites W1936842464 @default.
• W3202016208 cites W1971912541 @default.
• W3202016208 cites W1987294642 @default.
• W3202016208 cites W1996937517 @default.
• W3202016208 cites W1998172704 @default.
• W3202016208 cites W2004872316 @default.
• W3202016208 cites W2012257814 @default.
• W3202016208 cites W2014593984 @default.
• W3202016208 cites W2018182154 @default.
• W3202016208 cites W2028466425 @default.
• W3202016208 cites W2042388217 @default.
• W3202016208 cites W2069508460 @default.
• W3202016208 cites W2081453396 @default.
• W3202016208 cites W2087835012 @default.
• W3202016208 cites W2095665485 @default.
• W3202016208 cites W2101324476 @default.
• W3202016208 cites W2119741718 @default.
• W3202016208 cites W2132500820 @default.
• W3202016208 cites W2311740292 @default.
• W3202016208 cites W2413937595 @default.
• W3202016208 cites W2515195581 @default.
• W3202016208 cites W2526434349 @default.
• W3202016208 cites W2573748839 @default.
• W3202016208 cites W2606211344 @default.
• W3202016208 cites W2754076565 @default.
• W3202016208 cites W2769579842 @default.
• W3202016208 cites W3087888360 @default.
• W3202016208 cites W3091535295 @default.
• W3202016208 cites W2344735743 @default.
• W3202016208 doi "https://doi.org/10.5853/jos.2021.00626" @default.
• W3202016208 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8521247" @default.
• W3202016208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34649386" @default.
• W3202016208 hasPublicationYear "2021" @default.
• W3202016208 type Work @default.
• W3202016208 sameAs 3202016208 @default.
• W3202016208 citedByCount "1" @default.
• W3202016208 countsByYear W32020162082023 @default.
• W3202016208 crossrefType "journal-article" @default.
• W3202016208 hasAuthorship W3202016208A5001639544 @default.
• W3202016208 hasAuthorship W3202016208A5014833038 @default.
• W3202016208 hasAuthorship W3202016208A5028327919 @default.
• W3202016208 hasAuthorship W3202016208A5029089458 @default.
• W3202016208 hasAuthorship W3202016208A5034111842 @default.
• W3202016208 hasAuthorship W3202016208A5048277865 @default.
• W3202016208 hasAuthorship W3202016208A5054261442 @default.
• W3202016208 hasAuthorship W3202016208A5065085583 @default.
• W3202016208 hasAuthorship W3202016208A5091775106 @default.
• W3202016208 hasBestOaLocation W32020162081 @default.
• W3202016208 hasConcept C126322002 @default.
• W3202016208 hasConcept C25498285 @default.
• W3202016208 hasConcept C2777397205 @default.
• W3202016208 hasConcept C42219234 @default.
• W3202016208 hasConcept C541997718 @default.
• W3202016208 hasConcept C71924100 @default.
• W3202016208 hasConcept C98274493 @default.
• W3202016208 hasConceptScore W3202016208C126322002 @default.
• W3202016208 hasConceptScore W3202016208C25498285 @default.
• W3202016208 hasConceptScore W3202016208C2777397205 @default.
• W3202016208 hasConceptScore W3202016208C42219234 @default.
• W3202016208 hasConceptScore W3202016208C541997718 @default.
• W3202016208 hasConceptScore W3202016208C71924100 @default.
• W3202016208 hasConceptScore W3202016208C98274493 @default.
• W3202016208 hasFunder F4320322030 @default.
• W3202016208 hasFunder F4320322034 @default.
• W3202016208 hasFunder F4320322107 @default.
• W3202016208 hasFunder F4320322120 @default.
• W3202016208 hasIssue "3" @default.
• W3202016208 hasLocation W32020162081 @default.
• W3202016208 hasLocation W32020162082 @default.
• W3202016208 hasLocation W32020162083 @default.
• W3202016208 hasLocation W32020162084 @default.
• W3202016208 hasOpenAccess W3202016208 @default.
• W3202016208 hasPrimaryLocation W32020162081 @default.
• W3202016208 hasRelatedWork W152205061 @default.
• W3202016208 hasRelatedWork W1985681978 @default.
• W3202016208 hasRelatedWork W2003781670 @default.
• W3202016208 hasRelatedWork W2051135672 @default.
• W3202016208 hasRelatedWork W2054742223 @default.
• W3202016208 hasRelatedWork W2055505341 @default.
• W3202016208 hasRelatedWork W2167521548 @default.
• W3202016208 hasRelatedWork W2888004281 @default.
• W3202016208 hasRelatedWork W2978823757 @default.
• W3202016208 hasRelatedWork W3183836895 @default.

• next