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• W3202017883 abstract "Background: Women's reproductive factors include their age at menarche and menopause, the age at which they start and stop having children, and the number of children they have. Studies that have linked these factors with disease risk have largely investigated individual reproductive factors and have not considered the genetic correlation and total interplay that may occur between them. This study aimed to investigate the nature of the relationships between eight female reproductive factors. Methods: We used data from the UK Biobank and genetic consortia with data available for the following reproductive factors: age at menarche, age at menopause, age at first birth, age at last birth, number of births, being parous, age at first sex and lifetime number of sexual partners. Linkage disequilibrium score regression (LDSC) was performed to investigate the genetic correlation between reproductive factors. We then applied Mendelian randomization (MR) methods to estimate the causal relationships between these factors. Sensitivity analyses were used to investigate directionality of the effects, test for evidence of pleiotropy and account for sample overlap. Results: LDSC indicated that most reproductive factors are genetically correlated (rg range: |0.06 - 0.94|), though there was little evidence for genetic correlations between lifetime number of sexual partners and age at last birth, number of births and ever being parous (rg < 0.01). MR revealed potential causal relationships between many reproductive factors, including later age at menarche (1 SD increase) leading to a later age at first sexual intercourse (Beta (B)=0.09 SD, 95% confidence intervals (CI)=0.06,0.11), age at first birth (B=0.07 SD, CI=0.04,0.10), age at last birth (B=0.06 SD, CI=0.04,0.09) and age at menopause (B=0.06 SD, CI=0.03,0.10). Later age at first birth was found to lead to a later age at menopause (B=0.21 SD, CI=0.13,0.29), age at last birth (B=0.72 SD, CI=0.67,0.77) and a lower number of births (B=-0.38 SD, CI=-0.44,-0.32). Conclusion: This study presents evidence that women's reproductive factors are genetically correlated and causally related. Future studies examining the health sequelae of reproductive factors should consider a woman's entire reproductive history, including the causal interplay between reproductive factors." @default.
• W3202017883 created "2021-10-11" @default.
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• W3202017883 date "2021-09-29" @default.
• W3202017883 modified "2023-10-17" @default.
• W3202017883 title "The relationships between women's reproductive factors: a Mendelian randomization analysis." @default.
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• W3202017883 cites W1919053311 @default.
• W3202017883 cites W1966775465 @default.
• W3202017883 cites W1973447839 @default.
• W3202017883 cites W1974914579 @default.
• W3202017883 cites W1992808869 @default.
• W3202017883 cites W2000411992 @default.
• W3202017883 cites W2004712834 @default.
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• W3202017883 cites W2041215109 @default.
• W3202017883 cites W2047809751 @default.
• W3202017883 cites W2065655864 @default.
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• W3202017883 cites W2324862792 @default.
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• W3202017883 doi "https://doi.org/10.1101/2021.09.29.21264251" @default.
• W3202017883 hasPublicationYear "2021" @default.
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