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• W3202022248 endingPage "2049" @default.
• W3202022248 startingPage "2049" @default.
• W3202022248 abstract "Although antibiotics have been indispensable in the advancement of modern medicine, there are downsides to their use. Growing resistance to broad-spectrum antibiotics is leading to an epidemic of infections untreatable by first-line therapies. Resistance is exacerbated by antibiotics used as growth factors in livestock, over-prescribing by doctors, and poor treatment adherence by patients. This generates populations of resistant bacteria that can then spread resistance genes horizontally to other bacterial species, including commensals. Furthermore, even when antibiotics are used appropriately, they harm commensal bacteria leading to increased secondary infection risk. Effective antibiotic treatment can induce bacterial survival tactics, such as toxin release and increasing resistance gene transfer. These problems highlight the need for new approaches to treating bacterial infection. Current solutions include combination therapies, narrow-spectrum therapeutics, and antibiotic stewardship programs. These mediate the issues but do not address their root cause. One emerging solution to these problems is anti-virulence treatment: preventing bacterial pathogenesis instead of using bactericidal agents. In this review, we discuss select examples of potential anti-virulence targets and strategies that could be developed into bacterial infection treatments: the bacterial type III secretion system, quorum sensing, and liposomes." @default.
• W3202022248 created "2021-10-11" @default.
• W3202022248 creator A5012072102 @default.
• W3202022248 creator A5022603160 @default.
• W3202022248 creator A5080063239 @default.
• W3202022248 date "2021-09-28" @default.
• W3202022248 modified "2023-09-30" @default.
• W3202022248 title "The Case against Antibiotics and for Anti-Virulence Therapeutics" @default.
• W3202022248 cites W1510065878 @default.
• W3202022248 cites W1849979647 @default.
• W3202022248 cites W190540197 @default.
• W3202022248 cites W1921927525 @default.
• W3202022248 cites W1937785817 @default.
• W3202022248 cites W1964149427 @default.
• W3202022248 cites W1965442430 @default.
• W3202022248 cites W1968953113 @default.
• W3202022248 cites W1973213730 @default.
• W3202022248 cites W1973843350 @default.
• W3202022248 cites W1974616640 @default.
• W3202022248 cites W1975619709 @default.
• W3202022248 cites W1975846399 @default.
• W3202022248 cites W1975999946 @default.
• W3202022248 cites W1976812054 @default.
• W3202022248 cites W1979477952 @default.
• W3202022248 cites W1981661377 @default.
• W3202022248 cites W1985106082 @default.
• W3202022248 cites W1986466417 @default.
• W3202022248 cites W1988548811 @default.
• W3202022248 cites W1992034132 @default.
• W3202022248 cites W1992298603 @default.
• W3202022248 cites W1992622869 @default.
• W3202022248 cites W1994459154 @default.
• W3202022248 cites W1997756678 @default.
• W3202022248 cites W1997810742 @default.
• W3202022248 cites W1998027691 @default.
• W3202022248 cites W200012524 @default.
• W3202022248 cites W2003946063 @default.
• W3202022248 cites W2007002493 @default.
• W3202022248 cites W2008088946 @default.
• W3202022248 cites W2008679353 @default.
• W3202022248 cites W2009338783 @default.
• W3202022248 cites W2014783118 @default.
• W3202022248 cites W2015178572 @default.
• W3202022248 cites W2019936208 @default.
• W3202022248 cites W2021623392 @default.
• W3202022248 cites W2027017334 @default.
• W3202022248 cites W2028849559 @default.
• W3202022248 cites W2031402259 @default.
• W3202022248 cites W2036093108 @default.
• W3202022248 cites W2036593623 @default.
• W3202022248 cites W2036775991 @default.
• W3202022248 cites W2039560731 @default.
• W3202022248 cites W2043724690 @default.
• W3202022248 cites W2045373518 @default.
• W3202022248 cites W2046938811 @default.
• W3202022248 cites W2051961945 @default.
• W3202022248 cites W2059166844 @default.
• W3202022248 cites W2062482987 @default.
• W3202022248 cites W2065095479 @default.
• W3202022248 cites W2065512043 @default.
• W3202022248 cites W2065777365 @default.
• W3202022248 cites W2066080624 @default.
• W3202022248 cites W2069684779 @default.
• W3202022248 cites W2070278789 @default.
• W3202022248 cites W2071933111 @default.
• W3202022248 cites W2075736573 @default.
• W3202022248 cites W2078946678 @default.
• W3202022248 cites W2082035971 @default.
• W3202022248 cites W2082559230 @default.
• W3202022248 cites W2085693438 @default.
• W3202022248 cites W2090740705 @default.
• W3202022248 cites W2091213797 @default.
• W3202022248 cites W2092643722 @default.
• W3202022248 cites W2095670129 @default.
• W3202022248 cites W2095726375 @default.
• W3202022248 cites W2096829290 @default.
• W3202022248 cites W2097254694 @default.
• W3202022248 cites W2098499925 @default.
• W3202022248 cites W2099898008 @default.
• W3202022248 cites W2101233913 @default.
• W3202022248 cites W2102096105 @default.
• W3202022248 cites W2104518766 @default.
• W3202022248 cites W2104726234 @default.
• W3202022248 cites W2104948212 @default.
• W3202022248 cites W2105838618 @default.
• W3202022248 cites W2107496739 @default.
• W3202022248 cites W2108638835 @default.
• W3202022248 cites W2110313322 @default.
• W3202022248 cites W2113219905 @default.
• W3202022248 cites W2113482183 @default.
• W3202022248 cites W2113556993 @default.
• W3202022248 cites W2116105877 @default.
• W3202022248 cites W2116777154 @default.
• W3202022248 cites W2119114528 @default.
• W3202022248 cites W2120005441 @default.
• W3202022248 cites W2120655331 @default.
• W3202022248 cites W2122721391 @default.
• W3202022248 cites W2124117472 @default.

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