Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202023295> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W3202023295 abstract "<h3>Background</h3> A 15 year old girl required a significant reduction in Insulin detemir dose on commencement of Clarithromycin for treatment of acne. <h3>Objectives</h3> A case report describing a significant reduction in insulin detemir dose in order to self manage recurrent mild hypoglycaemia on starting oral Clarithromycin for acne, with no change in overall glycaemic control. <h3>Methods</h3> A 15 year old girl with established type 1 diabetes described at routine review she had required to lower her insulin detemir dose by 33% (13 units), after starting oral clarithromycin 500mg daily for treatment of acne over the 3 months prior to the review. She has experience recurrent mild self-managed hypoglycaemia until lowering the dose. Her short acting insulin dose was unchanged at 33 units per day. There were no other changes to her medication, clinical condition or lifestyle. Routine screening tests according showed no abnormalities including recent negative coeliac screen. <h3>Results</h3> The patients’ glycaemic control was similar over the 6 month review period between reviews. HBA1C 48 & 54 mmol/mol. 2 week average blood glucose (Xpert BM meter) prior to each review was 8.3 & 8.8 mmol/l (SD 3.2 & 3.3 mmol/l). Mild Hypoglycaemic event had resolved with dose reduction. No serious hypoglycaemic events requiring 3rd party intervention or admission had occurred. <h3>Conclusions</h3> This case demonstrates clear potential for clarithromycin treatment to require close monitoring of blood glucose control in patients on insulin detemir. Literature review showed few similar case reports and non in Children and young people. The effect appears to be due to clarithromycin and insulin detemir both being highly protein bound and the former able to displace the insulin increasing free insulin levels. Clinicians should be aware and counsel their patients and their carers of this important potential interaction between 2 common paediatric medicines." @default.
- W3202023295 created "2021-10-11" @default.
- W3202023295 creator A5029204298 @default.
- W3202023295 date "2021-09-30" @default.
- W3202023295 modified "2023-09-25" @default.
- W3202023295 title "1760 Hypoglycaemic effect of Clarithromycin in an adolescent with Type 1 Diabetes Mellitus" @default.
- W3202023295 doi "https://doi.org/10.1136/archdischild-2021-rcpch.836" @default.
- W3202023295 hasPublicationYear "2021" @default.
- W3202023295 type Work @default.
- W3202023295 sameAs 3202023295 @default.
- W3202023295 citedByCount "0" @default.
- W3202023295 crossrefType "proceedings-article" @default.
- W3202023295 hasAuthorship W3202023295A5029204298 @default.
- W3202023295 hasBestOaLocation W32020232951 @default.
- W3202023295 hasConcept C126322002 @default.
- W3202023295 hasConcept C134018914 @default.
- W3202023295 hasConcept C16005928 @default.
- W3202023295 hasConcept C187212893 @default.
- W3202023295 hasConcept C2776409635 @default.
- W3202023295 hasConcept C2776962512 @default.
- W3202023295 hasConcept C2777180221 @default.
- W3202023295 hasConcept C2777673923 @default.
- W3202023295 hasConcept C2779306644 @default.
- W3202023295 hasConcept C2779908123 @default.
- W3202023295 hasConcept C2779920387 @default.
- W3202023295 hasConcept C2780668416 @default.
- W3202023295 hasConcept C2780677441 @default.
- W3202023295 hasConcept C2781232474 @default.
- W3202023295 hasConcept C555293320 @default.
- W3202023295 hasConcept C71924100 @default.
- W3202023295 hasConceptScore W3202023295C126322002 @default.
- W3202023295 hasConceptScore W3202023295C134018914 @default.
- W3202023295 hasConceptScore W3202023295C16005928 @default.
- W3202023295 hasConceptScore W3202023295C187212893 @default.
- W3202023295 hasConceptScore W3202023295C2776409635 @default.
- W3202023295 hasConceptScore W3202023295C2776962512 @default.
- W3202023295 hasConceptScore W3202023295C2777180221 @default.
- W3202023295 hasConceptScore W3202023295C2777673923 @default.
- W3202023295 hasConceptScore W3202023295C2779306644 @default.
- W3202023295 hasConceptScore W3202023295C2779908123 @default.
- W3202023295 hasConceptScore W3202023295C2779920387 @default.
- W3202023295 hasConceptScore W3202023295C2780668416 @default.
- W3202023295 hasConceptScore W3202023295C2780677441 @default.
- W3202023295 hasConceptScore W3202023295C2781232474 @default.
- W3202023295 hasConceptScore W3202023295C555293320 @default.
- W3202023295 hasConceptScore W3202023295C71924100 @default.
- W3202023295 hasLocation W32020232951 @default.
- W3202023295 hasOpenAccess W3202023295 @default.
- W3202023295 hasPrimaryLocation W32020232951 @default.
- W3202023295 hasRelatedWork W1988549331 @default.
- W3202023295 hasRelatedWork W2045993936 @default.
- W3202023295 hasRelatedWork W2057262151 @default.
- W3202023295 hasRelatedWork W2057434408 @default.
- W3202023295 hasRelatedWork W2068655959 @default.
- W3202023295 hasRelatedWork W2083753940 @default.
- W3202023295 hasRelatedWork W2112253737 @default.
- W3202023295 hasRelatedWork W2121663374 @default.
- W3202023295 hasRelatedWork W2197938513 @default.
- W3202023295 hasRelatedWork W43716671 @default.
- W3202023295 isParatext "false" @default.
- W3202023295 isRetracted "false" @default.
- W3202023295 magId "3202023295" @default.
- W3202023295 workType "article" @default.