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- W3202037482 endingPage "130879" @default.
- W3202037482 startingPage "130879" @default.
- W3202037482 abstract "Early and accurate diagnosis of pathogenic bacteria is essential to prevent further infection from spreading and multiplying. Herein, an aptamer (Apt) biosensor based on Fe3O4@Au nanocomposites (NCs) has been proposed for capture, surface-enhanced Raman scattering (SERS) detection, and photothermal therapy (PTT) of S. aureus. Fe3O4@Au NCs become SERS substrate and photothermal agent due to superior surface plasmon properties and photothermal ability, while the aptamer immobilized on surface of Fe3O4@Au NCs acts as a capture agent. The detection limit of optimized Fe3O4@Au-Apt aptasensor for S. aureus is 25 cfu/mL, and cell capture efficiency (CCE) is as high as 68%. Moreover, our Fe3O4@Au-Apt NCs have high photothermal conversion efficiency of 39.28%, which have been proven as an excellent photothermal agent. As verified by experiments, Fe3O4@Au-Apt aptasensor is not only a promising tool to detect and photothermally inactivated S. aureus in milk samples, but also exhibits negligible cytotoxicity and good biocompatibility. This work shows a promising multifunctional nano-platform, which has great potential in specific recognition, sensitive SERS detection and PTT of S. aureus." @default.
- W3202037482 created "2021-10-11" @default.
- W3202037482 creator A5010738468 @default.
- W3202037482 creator A5011358668 @default.
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- W3202037482 creator A5047446019 @default.
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- W3202037482 creator A5085347958 @default.
- W3202037482 creator A5085888719 @default.
- W3202037482 creator A5089860286 @default.
- W3202037482 date "2022-01-01" @default.
- W3202037482 modified "2023-10-16" @default.
- W3202037482 title "Aptamer-conjugated magnetic Fe3O4@Au core-shell multifunctional nanoprobe: A three-in-one aptasensor for selective capture, sensitive SERS detection and efficient near-infrared light triggered photothermal therapy of Staphylococcus aureus" @default.
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- W3202037482 doi "https://doi.org/10.1016/j.snb.2021.130879" @default.
- W3202037482 hasPublicationYear "2022" @default.