FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202044891> ?p ?o ?g. }

• W3202044891 abstract "Abstract OBJECTIVE: 10-Year survival (10YS) after radical surgery for esophageal cancer (EC) patients (ECP) (T1-4N0-2M0) was analyzed. METHODS: We analyzed data of 551 consecutive ECP (age=56.5±8.9 years; tumor size=6±3.5 cm) radically operated (R0) and monitored in 1975-2021 (m=411, f=140; esophagogastrectomies (EG) Garlock=284, EG Lewis=267, combined EG with resection of pancreas, liver, diaphragm, aorta, VCS, colon transversum, lung, trachea, pericardium, splenectomy=154; adenocarcinoma=314, squamous=227, mix=10; T1=128, T2=115, T3=181, T4=127; N0=278, N1=70, N2=203; G1=157, G2=141, G3=253; early EC=109, invasive=442; only surgery=423, adjuvant chemoimmunoradiotherapy-AT=128: 5-FU+thymalin/taktivin+radiotherapy 45-50Gy). Multivariate Cox modeling, clustering, SEPATH, Monte Carlo, bootstrap and neural networks computing were used to determine any significant dependence. RESULTS: Overall life span (LS) was 1881.1±2230.6 days and cumulative 5-year survival (5YS) reached 52.1%, 10 years – 45.9%, 20 years – 33.7%. 184 ECP lived more than 5 years (LS=4308.7±2413.3 days), 99 ECP – more than 10 years (LS=5883±2296.6 days). 226 ECP died because of EC (LS=628.3±319.9 days). AT significantly improved 5YS (68.8% vs. 48.5%) (P=0.00025 by log-rank test). Cox modeling displayed that 10YS of ECP significantly depended on: phase transition (PT) N0—N12 in terms of synergetics, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), T, G, histology, age, AT, localization, blood cells, prothrombin index, hemorrhage time, residual nitrogen, protein (P=0.000-0.021). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 10YS and PT N0—N12 (rank=1), healthy cells/CC (2), PT early-invasive EC (3), thrombocytes/CC (4), erythrocytes/CC (5), lymphocytes/CC (6), eosinophils/CC (7), stick neutrophils/CC (8), segmented neutrophils/CC (9), monocytes/CC (10). leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0). CONCLUSIONS: 10-Year survival after radical procedures significantly depended on: 1) PT “early-invasive cancer”; 2) PT N0--N12; 3) Cell Ratio Factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) EC characteristics; 9) tumor localization; 10) anthropometric data; 11) surgery type. Optimal diagnosis and treatment strategies for EC are: 1) screening and early detection of EC; 2) availability of experienced thoracoabdominal surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for ECP with unfavorable prognosis." @default.
• W3202044891 created "2021-10-11" @default.
• W3202044891 creator A5020300227 @default.
• W3202044891 date "2021-10-01" @default.
• W3202044891 modified "2023-09-25" @default.
• W3202044891 title "Esophageal Cancer: 10-Year Survival After Surgery" @default.
• W3202044891 doi "https://doi.org/10.21203/rs.3.rs-936622/v1" @default.
• W3202044891 hasPublicationYear "2021" @default.
• W3202044891 type Work @default.
• W3202044891 sameAs 3202044891 @default.
• W3202044891 citedByCount "0" @default.
• W3202044891 crossrefType "posted-content" @default.
• W3202044891 hasAuthorship W3202044891A5020300227 @default.
• W3202044891 hasBestOaLocation W32020448911 @default.
• W3202044891 hasConcept C121608353 @default.
• W3202044891 hasConcept C126322002 @default.
• W3202044891 hasConcept C126894567 @default.
• W3202044891 hasConcept C2777863537 @default.
• W3202044891 hasConcept C2779742542 @default.
• W3202044891 hasConcept C50382708 @default.
• W3202044891 hasConcept C66339696 @default.
• W3202044891 hasConcept C71924100 @default.
• W3202044891 hasConcept C90924648 @default.
• W3202044891 hasConceptScore W3202044891C121608353 @default.
• W3202044891 hasConceptScore W3202044891C126322002 @default.
• W3202044891 hasConceptScore W3202044891C126894567 @default.
• W3202044891 hasConceptScore W3202044891C2777863537 @default.
• W3202044891 hasConceptScore W3202044891C2779742542 @default.
• W3202044891 hasConceptScore W3202044891C50382708 @default.
• W3202044891 hasConceptScore W3202044891C66339696 @default.
• W3202044891 hasConceptScore W3202044891C71924100 @default.
• W3202044891 hasConceptScore W3202044891C90924648 @default.
• W3202044891 hasLocation W32020448911 @default.
• W3202044891 hasOpenAccess W3202044891 @default.
• W3202044891 hasPrimaryLocation W32020448911 @default.
• W3202044891 hasRelatedWork W2124257467 @default.
• W3202044891 hasRelatedWork W2413169110 @default.
• W3202044891 hasRelatedWork W2593520145 @default.
• W3202044891 hasRelatedWork W2600035543 @default.
• W3202044891 hasRelatedWork W2894073994 @default.
• W3202044891 hasRelatedWork W3029840574 @default.
• W3202044891 hasRelatedWork W3030888969 @default.
• W3202044891 hasRelatedWork W3032162066 @default.
• W3202044891 hasRelatedWork W3147632986 @default.
• W3202044891 hasRelatedWork W4313488634 @default.
• W3202044891 isParatext "false" @default.
• W3202044891 isRetracted "false" @default.
• W3202044891 magId "3202044891" @default.
• W3202044891 workType "article" @default.