FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202044954> ?p ?o ?g. }

• W3202044954 endingPage "548" @default.
• W3202044954 startingPage "548" @default.
• W3202044954 abstract "Three new cyanobactins, trikoramides B (1)-D (3), have been isolated from the marine cyanobacterium, Symploca hydnoides, following a preliminary bioassay-guided isolation of the two most active polar fractions based on the brine shrimp toxicity assay. These new cyanobactins are new analogues of the previously reported cytotoxic trikoramide A (4) with differences mainly in the C-prenylated cyclotryptophan unit. Their planar structures were elucidated from their 1D and 2D NMR spectral data in combination with the HRMS/MS data. Marfey's method, 2D NOESY NMR spectroscopic and ECD spectra analyses were used to determine the absolute stereochemistry of trikoramides B (1)-D (3). Trikoramides B (1) and D (3) exhibited cytotoxicity against MOLT-4 acute lymphoblastic leukemia cell line with IC50 values of 5.2 µM and 4.7 µM, respectively. Compounds 1 and 3 were also evaluated for their quorum-sensing inhibitory assay based on the Pseudomonas aeruginosa PAO1 lasB-gfp and rhlA-gfp bioreporter strains. Although trikoramide B (1) exhibited weak quorum-sensing inhibitory activity, the Br-containing trikoramide D (3) exhibited moderate to significant dose-dependent quorum-sensing inhibitory activities against PAO1 lasB-gpf and rhlA-gfp bioreporter strains with IC50 values of 19.6 µM and 7.3 µM, respectively." @default.
• W3202044954 created "2021-10-11" @default.
• W3202044954 creator A5021357547 @default.
• W3202044954 creator A5023613178 @default.
• W3202044954 creator A5036437615 @default.
• W3202044954 creator A5067826948 @default.
• W3202044954 date "2021-09-28" @default.
• W3202044954 modified "2023-09-27" @default.
• W3202044954 title "Trikoramides B–D, Bioactive Cyanobactins from the Marine Cyanobacterium Symploca hydnoides" @default.
• W3202044954 cites W1880092145 @default.
• W3202044954 cites W1965088110 @default.
• W3202044954 cites W1988957091 @default.
• W3202044954 cites W1992542859 @default.
• W3202044954 cites W1993406872 @default.
• W3202044954 cites W2002211796 @default.
• W3202044954 cites W2021398206 @default.
• W3202044954 cites W2030377298 @default.
• W3202044954 cites W2034719937 @default.
• W3202044954 cites W2040238921 @default.
• W3202044954 cites W2043606605 @default.
• W3202044954 cites W2054422679 @default.
• W3202044954 cites W2057802070 @default.
• W3202044954 cites W2085960153 @default.
• W3202044954 cites W2087180814 @default.
• W3202044954 cites W2105387254 @default.
• W3202044954 cites W2146292204 @default.
• W3202044954 cites W2162481919 @default.
• W3202044954 cites W2261078516 @default.
• W3202044954 cites W2326842020 @default.
• W3202044954 cites W2743042724 @default.
• W3202044954 cites W2774431970 @default.
• W3202044954 cites W2949440028 @default.
• W3202044954 cites W2990698159 @default.
• W3202044954 cites W3152800206 @default.
• W3202044954 cites W3160919668 @default.
• W3202044954 cites W3174508613 @default.
• W3202044954 cites W64548748 @default.
• W3202044954 doi "https://doi.org/10.3390/md19100548" @default.
• W3202044954 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8539366" @default.
• W3202044954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34677447" @default.
• W3202044954 hasPublicationYear "2021" @default.
• W3202044954 type Work @default.
• W3202044954 sameAs 3202044954 @default.
• W3202044954 citedByCount "4" @default.
• W3202044954 countsByYear W32020449542022 @default.
• W3202044954 countsByYear W32020449542023 @default.
• W3202044954 crossrefType "journal-article" @default.
• W3202044954 hasAuthorship W3202044954A5021357547 @default.
• W3202044954 hasAuthorship W3202044954A5023613178 @default.
• W3202044954 hasAuthorship W3202044954A5036437615 @default.
• W3202044954 hasAuthorship W3202044954A5067826948 @default.
• W3202044954 hasBestOaLocation W32020449541 @default.
• W3202044954 hasConcept C104317684 @default.
• W3202044954 hasConcept C104488531 @default.
• W3202044954 hasConcept C109316439 @default.
• W3202044954 hasConcept C118687296 @default.
• W3202044954 hasConcept C150194340 @default.
• W3202044954 hasConcept C161733203 @default.
• W3202044954 hasConcept C173764188 @default.
• W3202044954 hasConcept C185592680 @default.
• W3202044954 hasConcept C19549132 @default.
• W3202044954 hasConcept C202751555 @default.
• W3202044954 hasConcept C2777637488 @default.
• W3202044954 hasConcept C2777752497 @default.
• W3202044954 hasConcept C523546767 @default.
• W3202044954 hasConcept C54355233 @default.
• W3202044954 hasConcept C55493867 @default.
• W3202044954 hasConcept C60987743 @default.
• W3202044954 hasConcept C71240020 @default.
• W3202044954 hasConcept C86803240 @default.
• W3202044954 hasConcept C89423630 @default.
• W3202044954 hasConceptScore W3202044954C104317684 @default.
• W3202044954 hasConceptScore W3202044954C104488531 @default.
• W3202044954 hasConceptScore W3202044954C109316439 @default.
• W3202044954 hasConceptScore W3202044954C118687296 @default.
• W3202044954 hasConceptScore W3202044954C150194340 @default.
• W3202044954 hasConceptScore W3202044954C161733203 @default.
• W3202044954 hasConceptScore W3202044954C173764188 @default.
• W3202044954 hasConceptScore W3202044954C185592680 @default.
• W3202044954 hasConceptScore W3202044954C19549132 @default.
• W3202044954 hasConceptScore W3202044954C202751555 @default.
• W3202044954 hasConceptScore W3202044954C2777637488 @default.
• W3202044954 hasConceptScore W3202044954C2777752497 @default.
• W3202044954 hasConceptScore W3202044954C523546767 @default.
• W3202044954 hasConceptScore W3202044954C54355233 @default.
• W3202044954 hasConceptScore W3202044954C55493867 @default.
• W3202044954 hasConceptScore W3202044954C60987743 @default.
• W3202044954 hasConceptScore W3202044954C71240020 @default.
• W3202044954 hasConceptScore W3202044954C86803240 @default.
• W3202044954 hasConceptScore W3202044954C89423630 @default.
• W3202044954 hasFunder F4320320709 @default.
• W3202044954 hasIssue "10" @default.
• W3202044954 hasLocation W32020449541 @default.
• W3202044954 hasLocation W32020449542 @default.
• W3202044954 hasLocation W32020449543 @default.
• W3202044954 hasLocation W32020449544 @default.
• W3202044954 hasOpenAccess W3202044954 @default.
• W3202044954 hasPrimaryLocation W32020449541 @default.

• next